Anna Sophia McKenney

Graduate Student

Lab Phone

646-888-2796

E-mail

mckennea@mskcc.org

Mentor

Ross L. Levine

Education

BS, Rensselaer Polytechnic Institute; MA, Johns Hopkins University

I’m interested in the intersection between public health and individual medicine, especially as it relates to diagnosis and prognosis. For my PhD, I wanted to focus on one research area, to become an expert in both the knowledge surrounding the topic and the scientific approach to problem solving. As an MD-PhD student, I’m drawn to research that can translate between the clinic and the bench. I found that Gerstner Sloan Kettering’s program really made this practicable for my research, and at the same time, it provided me with a strong background in cancer research through rigorous course work.

Publications

Kleppe M, Kwak M, Koppikar P, Riester M, Keller M, Bastian L, Hricik T, Bhagwat N, McKenney AS, Papalexi E, Abdel-Wahab O, Rampal R, Marubayashi S, Chen  JJ, Romanet V, Fridman JS, Bromberg J, Teruya-Feldstein J, Murakami M, Radimerski T, Michor F, Fan R, Levine RL. JAK-STAT pathway activation in malignant and nonmalignant cells contributes to MPN pathogenesis and therapeutic response. Cancer Discov. 2015 Mar;5(3):316-31. doi: 10.1158/2159-8290.CD-14-0736. Epub 2015 Jan 8. PubMed PMID: 25572172; PubMed Central PMCID: PMC4355105.

Rampal R, Ahn J, Abdel-Wahab O, Nahas M, Wang K, Lipson D, Otto GA, Yelensky R, Hricik T, McKenney AS, Chiosis G, Chung YR, Pandey S, van den Brink MR, Armstrong SA, Dogan A, Intlekofer A, Manshouri T, Park CY, Verstovsek S, Rapaport F, Stephens PJ, Miller VA, Levine RL. Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5401-10. doi: 10.1073/pnas.1407792111. Epub 2014 Dec 2. PubMed PMID: 25516983; PubMed Central PMCID: PMC4273376.

McKenney AS, Levine RL. Isocitrate dehydrogenase mutations in leukemia. J Clin Invest. 2013 Sep;123(9):3672-7. doi: 10.1172/JCI67266. Epub 2013 Sep 3. Review. PubMed PMID: 23999441; PubMed Central PMCID: PMC3754251.

Russ JB, McKenney AS, Patel AB. An identity crisis: the need for core competencies in undergraduate medical education. Med Educ Online. 2013 Apr 29;18:1-2. doi: 10.3402/meo.v18i0.21028. PubMed PMID: 23636108; PubMed Central PMCID: PMC3641287.

Francis ER, Goodsmith N, Michelow M, Kulkarni A, McKenney AS, Kishore SP, Bertelsen N, Fein O, Balsari S, Lemery J, Fitzgerald D, Johnson W, Finkel ML. The global health curriculum of Weill Cornell Medical College: how one school developed a global health program. Acad Med. 2012 Sep;87(9):1296-302. PubMed PMID: 22929431.

Tetenbaum-Novatt J, Hough LE, Mironska R, McKenney AS, Rout MP. Nucleocytoplasmic transport: a role for nonspecific competition in karyopherin-nucleoporin interactions. Mol Cell Proteomics. 2012 May;11(5):31-46. doi: 10.1074/mcp.M111.013656. Epub 2012 Feb 22. PubMed PMID: 22357553; PubMed Central PMCID: PMC3418842.

Barzilla JE, McKenney AS, Cowan AE, Durst CA, Grande-Allen KJ. Design and validation of a novel splashing bioreactor system for use in mitral valve organ culture. Ann Biomed Eng. 2010 Nov;38(11):3280-94. doi: 10.1007/s10439-010-0129-9. Epub 2010 Jul 27. PubMed PMID: 20661646; PubMed Central PMCID: PMC4412843.

Jovanovic-Talisman T, Tetenbaum-Novatt J, McKenney AS, Zilman A, Peters R, Rout MP, Chait BT. Artificial nanopores that mimic the transport selectivity of the nuclear pore complex. Nature. 2009 Feb 19;457(7232):1023-7. doi: 10.1038/nature07600. Epub 2008 Dec 21. PubMed PMID: 19098896; PubMed Central PMCID: PMC2764719.

Meyer SC, Keller MD, Chiu S, Koppikar P, Guryanova OA, Rapaport F, Xu K, Manova K, Pankov D, O’Reilly RJ, Kleppe M, McKenney AS, Shih AH, Shank K, Ahn J, Papalexi E, Spitzer B, Socci N, Viale A, Mandon E, Ebel N, Andraos R, Rubert J, Dammassa E, Romanet V, Dölemeyer A, Zender M, Heinlein M, Rampal R, Weinberg RS, Hoffman R, Sellers WR, Hofmann F, Murakami M, Baffert F, Gaul C, Radimerski T, Levine RL. (2015) CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms. Cancer Cell, 28, 15-28.  PMCID: PMC4503933