Human Oncology & Pathogenesis Program

The Ross Levine Lab

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Research

Ross L. Levine, MD

The goal of our research is to improve our understanding of the genetic basis of blood disorders known as myeloid malignancies, and to use this knowledge to improve therapies for patients with these disorders. Our efforts are focused on the identification and characterization of somatic mutations in hematologic malignancies using candidate gene, genome-wide, and functional approaches, with a specific interest in the role of aberrant signal transduction in malignant transformation and in the effects of mutations in epigenetic modifiers in myeloproliferative neoplasms (MPNs) and acute myeloid leukemia (AML). As a physician-scientist, we have a specific interest in translating this knowledge back to the clinic, in the preclinical and clinical evaluation of targeted therapies for leukemia patients, and in the development of clinically tractable genomic assays for patients with hematologic malignancies.

The Levine Lab

The Levine Lab

Featured News

In the Lab
Memorial Sloan Kettering physician-scientists Samuel Bakhoum, Ross Levine, and Michel Sadelain
AACR 2021 Research Roundup: Chromosomal Instability, Early Changes in Blood Cancer, Revamping CAR T Cell Therapy

MSK researchers shared their latest research developments at the 2021 meeting of the American Association for Cancer Research.
In the Lab
Postdoctoral fellows Linde Miles and Robert Bowman in the lab.
Single-Cell Study Sheds Light on Leukemia’s Family Tree

New research looks at how a series of mutations in normal blood cells can lead to them becoming cancerous and how these mutations accumulate as cancer progresses.
Finding
Researchers Ahmet Zehir and Elli Papaemmanuil talk while looking at a computer.
Why Do Certain Chemotherapies Increase the Likelihood of Blood Cancer?

New research focuses on clonal hematopoiesis, an age-related blood condition that increases the risk of blood cancer.

View All Featured News

Publications

Sykes SM, Kokkaliaris KD, Milsom MD, Levine RL, Majeti R. Clonal evolution of preleukemic hematopoietic stem cells in acute myeloid leukemia. Experimental hematology. 2015; 43(12):989-92.

Guryanova OA, Lieu YK, Garrett-Bakelman FE, Spitzer B, Glass JL, Shank K, Martinez AB, Rivera SA, Durham BH, Rapaport F, Keller MD, Pandey S, Bastian L, Tovbin D, Weinstein AR, Teruya-Feldstein J, Abdel-Wahab O, Santini V, Mason CE, Melnick AM, Mukherjee S, Levine RL. Dnmt3a regulates myeloproliferation and liver-specific expansion of hematopoietic stem and progenitor cells. Leukemia. 2016; 30(5):1133-42. NIHMSID: NIHMS745048

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People

Pictured: Dr. Ross Levine

Ross L. Levine, MD

  • Mechanisms of genetic and epigenetic cooperativity which drive myeloid transformation; Elucidating and modeling evolution from hematopoietic stem/progenitor cells to clonal hematopoiesis and then to myeloid malignancies; Identification and credentialing novel therapeutic dependencies in myeloid malignancies
  • MD, Johns Hopkins School of Medicine
leviner@mskcc.org
Email Address
View physician profile
Physician profile

Members

Anthony Martinez Benitez

Lab Technician

Robert Bowman
Robert Bowman

Postdoctoral Fellow

Louise Cai
Louise Cai

Research Technician

Sheng Cai, MD, PhD
Sheng Cai

Instructor, Department of Medicine

Christine Caprioli
Christine Caprioli

Project Coordinator

Andrew Dunbar, MD
Andrew Dunbar

Instructor, Department of Leukemia

Inés Fernández Maestre
Inés Fernández Maestre

GSK Graduate Student

Rebecca Gelfer
Rebecca Gelfer

GSK Graduate Student

Jacob Glass
Jacob Glass

Research Fellow

Emily Guzzardi

Lab Technician

Remie Houston
Remie Houston

Research Technician

Bing Li

Visiting Investigator

Linde Miles
Linde Miles

Postdoctoral Research Fellow

Shoron Mowla
Shoron Mowla

Research Technician

Young Park
Young Park

Senior Research Technician

Sonali Persaud
Sonali Persaud

Research Technician

Raajit K. Rampal, MD, PhD
Raajit K. Rampal

Assistant Attending

Troy Robinson
Troy Robinson

GSK Graduate Student

Daria Shlyueva
Daria Shlyueva

Postdoctoral Fellow

Aaron Stonestrom

Fellow

Pablo Sánchez Vela, MD
Pablo Sánchez Vela

Research Scholar

Michael Waarts

GSK Graduate Student

Matthew Wereski

Senior Research Technician

Xiaodi Wu

Fellow

Wenbin Xiao

Assistant Attending

Lab Alumni
Nicole Kucine, MD
Nicole Kucine
Sachie Marubayashi
Sachie Marubayashi

Research Technician

Alison Schram, BS
Alison Schram

Graduate Research Assistant

Jihae Ahn
Jihae Ahn

Research Technician

Lennart Bastian
Lennart Bastian

Research Technician

Neha Bhagwat
Neha Bhagwat

Associate Director, Translational Medicine at Prelude Therapeutics Inc., Wilmington, Delaware

Stephanie Braunstein
Stephanie Braunstein

Senior Research Technician

Sophia Chiu, MS
Sophia Chiu

Research Technician

Young Rock Chung

Research Technician

Keith Cordner

Research Technician

Isabelle Csete
Isabelle Csete

Research Technician

Nicole DelGaudio
Nicole DelGaudio

Research Technician

Lauren Dong

Research Technician

Vidushi Durani

Research Technician

Olga Guryanova
Olga Guryanova

Research Fellow

Megan Hatlen
Megan Hatlen

Research Fellow

Todd Hricik
Todd Hricik

Research Assistant

Abdul Karzai

Senior Research Technician

Matthew Keller
Matthew Keller

Research Technician

Outi Kilpivaara

Research Fellow

Maria Kleppe

Research Fellow

Priya Koppikar, PhD
Priya Koppikar

Research Fellow

Aishwarya Krishnan
Aishwarya Krishnan

Senior Research Technician

Hiroyoshi Kunimoto, MD, PhD
Hiroyoshi Kunimoto

Research Fellow

Lindsay M. Saunders, BS
Lindsay M. LaFave (Saunders)

Research Fellow

Anna Sophia McKenney
Anna Sophia McKenney

Interventional Radiology Resident at New York Presbyterian Hospital, New York, NY

Tiffany Merlinsky
Tiffany Merlinsky

NE Agency Contingent

Sara Meyer
Sara Meyer

Research Fellow

Tanmay Mishra

Senior Research Technician

Christine Mullane
Christine Mullane

Administrative Assistant

Abbas Nazir

Research Technician

Suveg Pandey, BS
Suveg Pandey

Research Technician

Efi Papalexi
Efi Papalexi

Research Technician

Friederike Pastore, MD
Friederike Pastore

Research Fellow

Jay Patel

Research Trainee

Elodie Pronier

Research Fellow

Franck Rapaport
Franck Rapaport

Senior Research Scientist

Shira Redlich
Shira Redlich

Senior Research Technician

Kaitlyn Shank
Kaitlyn Shank

Research Technician

Alan Shih, MD, PhD
Alan Shih

Assistant Attending

Amritha Hanasoqe Somasundara

Research Technician

B. Gila Spitzer
B. Gila Spitzer

Instructor, Department of Pediatrics

Pictured: Aaron Viny
Aaron Viny

Assistant Attending

Karen Wei
Karen Wei

Lab Manager

Brittany A. Woods
Brittany A. Woods

Equity Research Associate at William Blair Cowen, Inc., New York, NY

Anouar Zouak

Research Technician

Lab Affiliations

Achievements

  • Scholar, Leukemia and Lymphoma Society Scholar (2012)
  • Louis and Allston Boyer Young Investigator Award for Basic Research, Memorial Sloan Kettering Cancer Center (2011)
  • Member, American Society of Clinical Investigation (2011)
  • Sir William Osler Young Investigator Award, Interurban Clinical Club (2011)

Get in Touch

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Ross L. Levine discloses the following relationships and financial interests:

  • Ajax Therapeutics, Inc.
    Fiduciary Role/Position; Intellectual Property Rights; Ownership / Equity Interests; Provision of Services (uncompensated)
  • Anovia Biosciences, Inc
    Ownership / Equity Interests
  • AstraZeneca
    Provision of Services
  • Auron Therapeutics, Inc.
    Ownership / Equity Interests; Provision of Services (uncompensated)
  • Bakx Therapeutics
    Ownership / Equity Interests; Provision of Services (uncompensated)
  • BridgeBio Inc.
    Provision of Services
  • C4 Therapeutics
    Ownership / Equity Interests; Provision of Services
  • Celgene
    Provision of Services
  • Cure Breast Cancer Foundation
    Intellectual Property Rights
  • ECOG-ACRIN Cancer Research Group
    Provision of Services (uncompensated)
  • Epiphanes, Inc.
    Ownership / Equity Interests
  • Epizyme
    Intellectual Property Rights
  • Genome Quebec
    Provision of Services
  • Gilead Pharmaceutical
    Provision of Services
  • Imago Biosciences
    Ownership / Equity Interests; Provision of Services (uncompensated)
  • Incyte
    Provision of Services
  • Isoplexis Corporation
    Ownership / Equity Interests
  • Janssen Pharmaceuticals, Inc.
    Provision of Services
  • Jubilant Therapeutics Inc.
    Provision of Services
  • Kurome Therapeutics, Inc.
    Ownership / Equity Interests
  • Lilly Oncology
    Provision of Services
  • Mana Therapeutics, Inc.
    Ownership / Equity Interests; Provision of Services
  • Mission Bio
    Ownership / Equity Interests; Provision of Services (uncompensated)
  • Novartis Pharmaceuticals Corporation
    Provision of Services
  • PharmaEssentia
    Provision of Services
  • Prelude Therapeutics
    Ownership / Equity Interests; Provision of Services
  • Qiagen
    Fiduciary Role/Position; Ownership / Equity Interests; Provision of Services (uncompensated)
  • Scorpion Therapeutics, Inc.
    Ownership / Equity Interests; Provision of Services
  • Syndax
    Ownership / Equity Interests; Provision of Services
  • The Mark Foundation
    Fiduciary Role/Position; Provision of Services
  • University of Helsinki
    Provision of Services
  • Zentalis Pharmaceuticals
    Ownership / Equity Interests; Provision of Services

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2020 through disclosure submission in spring 2021). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.


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