Memorial Hospital Research Laboratories

The Paul Romesser Lab


MSK radiation oncologist Paul Romesser
Paul Romesser, MD
Assistant Attending

Research of the Paul Romesser Laboratory focuses on three main concepts. First is the characterization of the processes of senescence. This includes senescence-associated secretory phenotype (SASP) induction and tumor microenvironment (TME) remodeling in response to radiation. Similarly, we seek to investigate pathways responsible for the anti-tumor immunomodulatory effects seen with radiation induced senescence. Harmonizing these together, we work to exploit senescence therapeutically to push the body’s immune response towards tumor rejection. As a radiation oncologist, the research we perform represents translational work that will improve therapeutic options for patients with colorectal cancer. Our close collaboration with surgical oncologist J. Joshua Smith, Chief of Colorectal Service Julio Garcia-Aguilar, and Chair of Radiation Oncology Simon Powell, has allowed us to develop various clinical trials that parallel the laboratory research we perform. This scientific inquiry is supported using our rectal cancer organoid models that recapitulate the myriad physiological characteristics of this disease. In doing so, this allows us to better understand the mechanisms by which radiation response in colorectal cancer occurs in immunocompromised and immunocompetent settings.

Publications Highlights

Romesser PB and Lowe SW. The Potent and Paradoxical Biology of Cellular Senescence in Cancer. Annual Review of Cancer Biology. 2023. Vol. 7: 207-228. Available from: doi: 10.1146/annurev-cancerbio-061421-124434.

Kim JK, Wu C, Del Latto M, Gao Y, Choi S, Kierstead M, Sauvé CG, Firat C, Chaves Perez A, Sillanpaa J, Chen C, Lawrence KE, Paty PB, Barriga FM, Wilkinson JE, Shia J, Sawyers CL, Lowe SW, García-Aguilar J, Romesser PB, and Smith JJ. An Immunocompetent Rectal Cancer Model to Study Radiation Therapy. Cell Reports Methods. 2022. Vol. 2 (12): 100353. Available from: doi: 10.1016/j.crmeth.2022.100353.

Falcone M, Uribe AH, Papalazarou V, Newman AC, Athineos D, Stevenson K, Sauvé CG, Gao Y, Kim JK, Del Latto M, Kierstead M, Wu C, Smith JJ, Romesser PB, Chalmers AJ, Blyth K, and Maddocks ODK. British Journal of Cancer. 2022. Vol. 127: 1773-1786. Available from: doi: 10.1038/s41416-022-01965-6.

Romesser PB, Kim AS, Jeong J, Mayle A, Dow LE, and Lowe SW. Proceedings of the National Academy of Sciences of the United States of America. 2019. Vol. 116 (41): 20672-20678. Avaialble from: doi: 10.1073/pnas.1906611116.

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MSK radiation oncologist Paul Romesser

Paul Romesser, MD

Assistant Attending

  • The Romesser lab studies colorectal and anal cancer with a focus on using radiotherapy to treat disease.
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Michael Del Latto

Senior Research Technician

Sara Yoder

Research Technician

Lab Alumni
Maria Kierstead

Research Technician

Amanda Kim

Senior Research Technician

Lab Affiliations

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