Human Oncology & Pathogenesis Program

The Ping Chi Lab

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Research

Ping Chi
Ping Chi, MD, PhD

It is well recognized that the cellular context contributes to susceptibility to oncogenic transformation mediated by different “driver” oncogenes. The focus of our laboratory is to discover and understand the critical genetic and epigenetic factors that determine the cellular-context-dependent oncogenesis in distinct cancer types, with a primary focus on sarcoma and melanoma. We use multimodality approaches, including  transcriptome analyses, epigenome mapping, and gene-expression-based high-throughput screens, as well as murine models to understand the mechanisms of pathogenesis and to develop biomarkers and targeted therapies based on insight into disease pathogenesis.

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Chi Lab

Featured News

Pictured: Ping Chi
At Work: Physician-Scientist Ping Chi

Ping Chi, a physician-scientist and member of the Human Oncology and Pathogenesis Program, studies genetic and epigenetic changes that cause cancer.
Event
Graduates and speakers pose on a stage
2017 MSK Convocation and Commencement Ceremony Celebrates Distinguished Scientists and Young Scholars

Degrees were presented and awards were given at the 38th annual ceremony held on May 18.
In the Lab
Pictured: Ping Chi
Molecular Studies Provide New Clues about Rare Soft Tissue Sarcoma

Genetic analysis reveals biomarkers and possible drug targets for malignant peripheral nerve sheath tumors.

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Publications

Patton EE, Mueller KL, Adams DJ, Anandasabapathy N, Aplin AE, Bertolotto C, Bosenberg M, Ceol CJ, Burd CE, Chi P, Herlyn M, Holmen SL, Karreth FA, Kaufman CK, Khan S, Kobold S, Leucci E, Levy C, Lombard DB, Lund AW, Marie KL, Marine JC, Marais R, McMahon M, Robles-Espinoza CD, Ronai ZA, Samuels Y, Soengas MS, Villanueva J, Weeraratna AT, White RM, Yeh I, Zhu J, Zon LI, Hurlbert MS, Merlino G. Melanoma models for the next generation of therapies. Cancer Cell. 2021 May 10;39(5):610-631.

Saqcena M, Leandro-Garcia LJ, Maag JLV, Tchekmedyian V, Krishnamoorthy GP, Tamarapu PP, Tiedje V, Reuter V, Knauf JA, de Stanchina E, Xu B, Liao XH, Refetoff S, Ghossein R, Chi P, Ho AL, Koche RP, Fagin JA. SWI/SNF Complex Mutations Promote Thyroid Tumor Progression and Insensitivity to Redifferentiation Therapies. Cancer Discov. 2021 May;11(5):1158-1175.

Rousseau B, Foote MB, Maron SB, Diplas BH, Lu S, Argilés G, Cercek A, Diaz LA Jr. The Spectrum of Benefit from Checkpoint Blockade in Hypermutated Tumors. N Engl J Med. 2021 Mar 25;384(12):1168-1170.

Stahl M, Menghrajani K, Derkach A, Chan A, Xiao W, Glass J, King AC, Daniyan AF, Famulare C, Cuello BM, Horvat TZ, Abdel-Wahab O, Levine RL, Viny AD, Stein EM, Cai SF, Roshal M, Tallman MS, Goldberg AD. Clinical and molecular predictors of response and survival following venetoclax therapy in relapsed/refractory AML. Blood Adv. 2021 Mar 9;5(5):1552-1564.

Hitchman TD, Bayshtok G, Ceraudo E, Moore AR, Lee C, Jia R, Wang N, Pachai MR, Shoushtari AN, Francis JH, Guan Y, Chen J, Chang MT, Taylor BS, Sakmar TP, Huber T, Chi P, Chen Y. Combined Inhibition of Gαq and MEK Enhances Therapeutic Efficacy in Uveal Melanoma. Clin Cancer Res. 2021 Mar 1;27(5):1476-1490.

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People

Ping Chi

Ping Chi, MD, PhD

  • Physician-scientist Ping Chi studies genetic and epigenetic mechanisms of transcriptional regulation by oncogenic factors in GIST, MPNST, melanoma and other solid tumors.
  • MD, Weill Cornell Medical College
  • PhD, The Rockefeller University
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Physician profile

Members

Gabriella Bayshtok

Research Technician

Cindy Lee
Cindy Lee

Research Assistant

Miguel Miranda-Roman
Miguel Miranda-Roman

GSK Graduate Student

Mohini Pachai
Mohini Pachai

Research Technician

Amish Patel
Amish Patel

Research Associate

Fanny Tomas

Research Fellow

Elissa Wai Pung Wong
Elissa Wai Pung Wong

Senior Research Scientist

Juan Yan

Research Scholar

Lab Alumni
Yuanyuan Xie
Yuanyuan Xie

Research Fellow

Yuedan Chen
Yuedan Chen

Graduate Research Assistant

Dan Li, Research Fellow
Dan Li

Research Fellow

Devan Murphy
Devan Murphy

Research Technician

Shraddha Pancholi
Shraddha Pancholi

Research Secretary

Jessica Sher
Jessica Sher

Research Technician

Inna Sirota
Inna Sirota

Research Technician

Sewit Teckie
Sewit Teckie

Radiation Oncology Resident

Edward Walczak
Edward Walczak

Research Technician

Thomas Wiesner
Thomas Wiesner

Research Fellow

Qifan Zhang
Qifan Zhang

Research Technician

Lab Affiliations

Achievements

  • Kimmel Scholar Award, Sidney Kimmel Foundation (2012)
  • Research Grant, Sarcoma Foundation of America (2012)
  • Grant, GIST Cancer Awareness Foundation (2012)
  • Director’s New Innovator Award, National Institutes of Health (2012)
  • Clinical Scientist Development Award, National Instistutes of Health (2011)

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Ping Chi discloses the following relationships and financial interests:

  • Zai Lab
    Provision of Services

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2020 through disclosure submission in spring 2021). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].


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