Human Oncology & Pathogenesis Program

The Ping Chi Lab

Research

Ping Chi, MD, PhD

It is well recognized that the cellular context contributes to susceptibility to oncogenic transformation mediated by different “driver” oncogenes. The focus of our laboratory is to discover and understand the critical genetic and epigenetic factors that determine the cellular-context-dependent oncogenesis in distinct cancer types, with a primary focus on sarcoma and melanoma. We use multimodality approaches, including transcriptome analyses, epigenome mapping, and gene-expression-based high-throughput screens, as well as murine models to understand the mechanisms of pathogenesis and to develop biomarkers and targeted therapies based on insight into disease pathogenesis.

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Featured News

At Work: Physician-Scientist Ping Chi

Finding

Looking Beyond DNA Defects to Characterize Cancer

Wednesday, November 18, 2015

Event

2017 MSK Convocation and Commencement Ceremony Celebrates Distinguished Scientists and Young Scholars

Monday, May 22, 2017

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Publications

Yan Z, Chi P, Bibb JA, Ryan TA, Greengard P. Roscovitine: a novel regulator of P/Q-type calcium channels and transmitter release in central neurons. J Physiol. 2002 May 1;540(Pt 3):761-70.

Chi P, Greengard P, Ryan TA. Synaptic vesicle mobilization is regulated by distinct synapsin I phosphorylation pathways at different frequencies. Neuron. 2003 Apr 10;38(1):69-78.

Chi P, Chen Y, Zhang L, Guo X, Wongvipat J, Shamu T, Fletcher JA, Dewell S, Maki RG, Zheng D, Antonescu CR, Allis CD, Sawyers CL. ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours. Nature. 2010 Oct 14;467(7317):849-53. doi: 10.1038/nature09409. Epub 2010 Oct 3.

Chen Y, Shamu T, Chen H, Besmer P, Sawyers CL, Chi P. Visualization of the interstital cells of cajal (ICC) network in mice. Journal of Visualized Experiments, JoVE 2011; Jul27;(53).pii2802. doi10.3791/2802.

Chen Y, Chi P, Rockowitz S, Iaquinta PJ, Shamu T, Shukla S, Gao D, Sirota I, Carver BS, Wongvipat J, Scher HI, Zheng D, Sawyers CL. (2013) ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss. Nature Medicine. In press

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People

Ping Chi, MD, PhD

Physician-scientist Ping Chi studies genetic and epigenetic mechanisms of transcriptional regulation by oncogenic factors in GIST, MPNST, melanoma and other solid tumors.
MD, Weill Cornell Medical College
PhD, The Rockefeller University