The Vinod Balachandran Lab

Our laboratory investigates the fundamental relationships between antigens and T cells in solid tumors. We are interested in understanding how the spectrum of cancer antigens modulate T cell phenotype, function, fate, and plasticity in human cancer. Our group has specifically focused on human pancreatic cancer, and has used immunologic, genomic, molecular, and computational techniques to identify T cell antigens in rare pancreatic cancer survivors, as a platform for novel biomarker and target discovery, and to uncover principles governing antigen-T cell interactions. Our primary objective is to deepen our understanding of T cell immunobiology in cancer, and to facilitate development of novel cancer vaccines and immunotherapies.

Pictured: Dr. Vinod Balachandran

Vinod Balachandran, MD

Member, David. M Rubenstein Center for Pancreatic Cancer Research

Research Focus

Surgeon scientist Vinod Balachandran investigates T cell immunobiology in pancreatic cancer.

Education

MD, State University of New York at Stony Brook
Publications
  • Moral JA, Leung J, Rojas L, Ruan J, Zhao J, Sethna Z, Ramnarain A, Gasmi B, Gururajan M, Redmond D, Askan G, Bhanot U, Elyada E, Park Y, Tuveson DA, Goen M, Leach SD, Wolchok JD, DeMatteo RP, Merghoub T & Balachandran VP. ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity. Nature. 2020 Feb 19 Nature Paper#2019-03-03377D
  • Balachandran VP, Łuksza M, Zhao JN, Makarov V, Moral JA, Remark R, Herbst B, Askan G, Bhanot U, Senbabaoglu Y, Wells DK, Cary CIO, Grbovic-Huezo O, Attiyeh M, Medina B, Zhang J, Loo J, Saglimbeni J, Abu-Akeel M, Zappasodi R, Riaz N, Smoragiewicz M, Kelley ZL, Basturk O; Australian Pancreatic Cancer Genome Initiative; Gönen M, Levine AJ, Allen PJ, Fearon DT, Merad M, Gnjatic S, Iacobuzio-Donahue CA, Wolchok JD, DeMatteo RP, Chan TA, Greenbaum BD, Merghoub T, Leach SD. Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer. Nature. 2017 Nov 8. doi: 10.1038/nature24462. [Epub ahead of print]. PMID: 29132146
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Selected Achievements
  • Society of Immunotherapy for Cancer Presidential Award (2017)
  • National Cancer Institute Cancer Moonshot Award (2017)
  • Damon Runyon Clinical Investigator Award (2017)
  • AACR/Pancreatic Cancer Action Network Career Development Award (2017)
  • NCI Paul Calabresi Career Development Award (2016)
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  • Society of Surgical Oncology Harvey Barker Award (2015)
  • David and Monica Gorin Fellow Award (2013)
  • Memorial Sloan Kettering Chairman’s Award for Best Basic Science Research (2010)
  • Society of University Surgeons Research Fellowship Award (2009)
  • Alpha Omega Alpha