Training Grants for Postdoctoral Fellows

Pictured: CSCB Fellows

The Center for Stem Cell Biology (CSCB) was awarded a grant from the New York State Department of Health and the Empire State Stem Cell Board to support training in stem cell research. The grant sponsors five postdoctoral fellows who show exceptional potential for making significant contributions to the field of stem-cell-related research. Our trainees have the opportunity to take advantage of the unique resources available at Memorial Sloan Kettering, ranging from basic developmental biology and genetic lineage tracing to pluripotency, directed differentiation, stem cell engineering, chemical/genetic screening, and regenerative medicine, including clinical-grade cell processing.

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Pictured: Former CSCB Fellows

Pictured: Celia Andreu-Agullo
Celia Andreu-Agullo, PhD, Research Fellow, Developmental Biology Program

Project Title: Role of Arsenic-Resistant Protein 2 (Ars2) in the Regulation of Adult Neural Stem Cells


Pictured: Fiona Bangs
Fiona Bangs, PhD, Research Fellow, Developmental Biology Program

Project Title: The Role of Cilia and Centrosomes in Self-Renewal and Differentiation of Mouse Embryonic Stem Cells


Pictured: Kosuke Funato
Kosuke Funato, PhD, Research Fellow, Department of Neurosurgery

Project Title: Human ES-based modeling of pediatric glioblastoma by histone mutations


Picutred: Dong Gao
Dong Gao, PhD, Research Fellow, Human Oncology & Pathogenesis Program

Project Title: Defining the prostate luminal stem cell and cell of origin of prostate cancer


Pictured: Federico González Grassi
Federico González Grassi, PhD, Research Fellow, Developmental Biology Program

Project Title: Understanding the Mechanisms That Govern the Reprogramming of a Somatic Cell to a Pluripotent State.


Eric Kallin, PhD, Postdoctoral Fellow

Project Title: Role of alternative polyadenylation in embryonic stem cell identity and differentiation


Pictured: Jorge Mansilla-Soto
Jorge Mansilla-Soto, PhD, Research Fellow, Molecular Pharmacology Program

Project Title: Gene Repair and Erythroid Differentiation Potential of Sickle-Cell-Anemia-Induced Pluripotent Stem Cells


Pictured: Santosha Vardhana
Santosha Vardhana, MD, PhD, Postdoctoral Fellow, Cancer Biology & Genetics Program

Project Title: Erk inhibition promotes Brd4-independent stemness and proliferation in mouse embryonic stem cells


Pictured: Elsa Vera
Elsa Vera, PhD, Research Fellow, Developmental Biology Program

Project Title: Accelerating in Vitro Neural Aging by Manipulations of Telomerase Function and Its Application for Modeling Late-Onset Disease


Qiong Wang, PhD, Research Scholar, Cancer Biology & Genetics Program

Project Title: The p53 Tumor Suppressor Family Integrates Nodal and Wnt Inputs Driving Mesendoderm Specification


Pictured: Yang Yu
Yang Yu, PhD, Research Fellow, Developmental Biology Program

Project Title: Mechanism of Ars2 in regulating neural stem cell development


Pictured: Xinjun Zhang
Xinjun Zhang, PhD, Research Scholar, Developmental Biology Program

Project Title: Accelerated Generation of Functional Cortical Neurons from Human Embryonic Stem Cells Using Combinatorial Small-Molecule Treatment


Pictured: Zengrong Zhu
Zengrong Zhu, PhD, Research Fellow, Developmental Biology Program

Project Title: Genome editing in human embryonic stem cells to study the genetics of neonatal diabetes and pancreatic development


Pictured: Bastian Zimmer
Bastian Zimmer, PhD, Research Fellow, Developmental Biology Program

Project Title: Tailored hPSC-based cell therapy for hypopituitarism

Publications

Amin S, Cook B, Zhou T, Ghazizadeh Z, Lis R, Zhang T, Khalaj M, Crespo M, Perera M, Xiang JZ, Zhu Z, Tomishima M, Liu C, Naji A, Evans T, Huangfu D, Chen S. Discovery of a drug candidate for GLIS3-associated diabetes. Nat Commun. 2018 Jul 11;9(1):2681. doi: 10.1038/s41467-018-04918-x.

Puca L, Bareja R, Prandi D, Shaw R, Benelli M, Karthaus WR, Hess J, Sigouros M, Donoghue A, Kossai M, Gao D, Cyrta J, Sailer V, Vosoughi A, Pauli C, Churakova Y, Cheung C, Deonarine LD, McNary TJ, Rosati R, Tagawa ST, Nanus DM, Mosquera JM, Sawyers CL, Chen Y, Inghirami G, Rao RA, Grandori C, Elemento O, Sboner A, Demichelis F, Rubin MA, Beltran H. Patient derived organoids to model rare prostate cancer phenotypes. Nat Commun. 2018 Jun 19;9(1):2404. doi: 10.1038/s41467-018-04495-z.

Liu WA, Chen S, Li Z, Lee CH, Mirzaa G, Dobyns WB, Ross ME, Zhang J, Shi SH. PARD3 dysfunction in conjunction with dynamic HIPPO signaling drives cortical enlargement with massive heterotopia. Genes Dev. 2018 Jun 1;32(11-12):763-780. doi: 10.1101/gad.313171.118. Epub 2018 Jun 13.

Finley LWS, Vardhana SA, Carey BW, Alonso-Curbelo D, Koche R, Chen Y, Wen D, King B, Radler MR, Rafii S, Lowe SW, Allis CD, Thompson CB. Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity. Nat Cell Biol. 2018 May;20(5):565-574. doi: 10.1038/s41556-018-0086-3. Epub 2018 Apr 16.

Xie Y, Cao Z, Wong EW, Guan Y, Ma W, Zhang JQ, Walczak EG, Murphy D, Ran L, Sirota I, Wang S, Shukla S, Gao D, Knott SR, Chang K, Leu J, Wongvipat J, Antonescu CR, Hannon G, Chi P, Chen Y. COP1/DET1/ETS axis regulates ERK transcriptome and sensitivity to MAPK inhibitors. J Clin Invest. 2018 Apr 2;128(4):1442-1457. doi: 10.1172/JCI94840. Epub 2018 Mar 5.

Zhang SY, Clark NE, Freije CA, Pauwels E, Taggart AJ, Okada S, Mandel H, Garcia P, Ciancanelli MJ, Biran A, Lafaille FG, Tsumura M, Cobat A, Luo J, Volpi S, Zimmer B, Sakata S, Dinis A, Ohara O, Garcia Reino EJ, Dobbs K, Hasek M, Holloway SP, McCammon K, Hussong SA, DeRosa N, Van Skike CE, Katolik A, Lorenzo L, Hyodo M, Faria E, Halwani R, Fukuhara R, Smith GA, Galvan V, Damha MJ, Al-Muhsen S, Itan Y, Boeke JD, Notarangelo LD, Studer L, Kobayashi M, Diogo L, Fairbrother WG, Abel L, Rosenberg BR, Hart PJ, Etzioni A, Casanova JL.Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection. Cell. 2018 Feb 22;172(5):952-965.e18. doi: 10.1016/j.cell.2018.02.019.

Martin-Malpartida P, Batet M, Kaczmarska Z, Freier R, Gomes T, Aragón E, Zou Y, Wang Q, Xi Q, Ruiz L, Vea A, Márquez JA, Massagué J, Macias MJ. Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors. Nat Commun. 2017 Dec 12;8(1):2070. doi: 10.1038/s41467-017-02054-6.

Verma N, Zhu Z, Huangfu D. CRISPR/Cas-Mediated Knockin in Human Pluripotent Stem Cells. Methods Mol Biol. 2017;1513:119-140.

Tchieu J, Zimmer B, Fattahi F, Amin S, Zeltner N, Chen S, Studer L. A Modular Platform for Differentiation of Human PSCs into All Major Ectodermal Lineages. Cell Stem Cell. 2017 Sep 7;21(3):399-410.e7. doi: 10.1016/j.stem.2017.08.015.

Viswanathan VS, Ryan MJ, Dhruv HD, Gill S, Eichhoff OM, Seashore-Ludlow B, Kaffenberger SD, Eaton JK, Shimada K, Aguirre AJ, Viswanathan SR, Chattopadhyay S, Tamayo P, Yang WS, Rees MG, Chen S, Boskovic ZV, Javaid S, Huang C, Wu X, Tseng YY, Roider EM, Gao D, Cleary JM, Wolpin BM, Mesirov JP, Haber DA, Engelman JA, Boehm JS, Kotz JD, Hon CS, Chen Y, Hahn WC, Levesque MP, Doench JG, Berens ME, Shamji AF, Clemons PA, Stockwell BR, Schreiber SL. Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Nature. 2017 Jul 27;547(7664):453-457. doi: 10.1038/nature23007. Epub 2017 Jul 5.

Wang S, Gao D, Chen Y. The potential of organoids in urological cancer research. Nat Rev Urol. 2017 Jul;14(7):401-414. doi: 10.1038/nrurol.2017.65. Epub 2017 May 23. Review.

Zhang XJ, Li Z, Han Z, Sultan KT, Huang K, Shi SH. Precise inhibitory microcircuit assembly of developmentally related neocortical interneurons in clusters. Nat Commun. 2017 Jul 13;8:16091. doi: 10.1038/ncomms16091.

Shi ZD, Lee K, Yang D, Amin S, Verma N, Li QV, Zhu Z, Soh CL, Kumar R, Evans T, Chen S, Huangfu D. Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic Development. Cell Stem Cell. 2017 May 4;20(5):675-688.e6. doi: 10.1016/j.stem.2017.01.001. Epub 2017 Feb 9.

Shi ZD, Soh CL, Zhu Z, Huangfu D. Genome Editing and Directed Differentiation of hPSCs for Interrogating Lineage Determinants in Human Pancreatic Development. J Vis Exp. 2017 Mar 5;(121). doi: 10.3791/55267.

Blattner M, Liu D, Robinson BD, Huang D, Poliakov A, Gao D, Nataraj S, Deonarine LD, Augello MA, Sailer V, Ponnala L, Ittmann M, Chinnaiyan AM, Sboner A, Chen Y, Rubin MA, Barbieri CE. SPOP Mutation Drives Prostate Tumorigenesis In Vivo through Coordinate Regulation of PI3K/mTOR and AR Signaling. Cancer Cell. 2017 Mar 13;31(3):436-451. doi: 10.1016/j.ccell.2017.02.004.

Qi Y, Zhang XJ, Renier N, Wu Z, Atkin T, Sun Z, Ozair MZ, Tchieu J, Zimmer B, Fattahi F, Ganat Y, Azevedo R, Zeltner N, Brivanlou AH, Karayiorgou M, Gogos J, Tomishima M, Tessier-Lavigne M, Shi SH, Studer L. Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells. Nat Biotechnol. 2017 Feb;35(2):154-163. doi: 10.1038/nbt.3777. Epub 2017 Jan 23.

Yang Z, Peng YC, Gopalan A, Gao D, Chen Y, Joyner AL. Stromal hedgehog signaling maintains smooth muscle and hampers micro-invasive prostate cancer. Dis Model Mech. 2017 Jan 1;10(1):39-52. doi: 10.1242/dmm.027417. Epub 2016 Nov 30.

Zeltner N, Fattahi F, Dubois NC, Saurat N, Lafaille F, Shang L, Zimmer B, Tchieu J, Soliman MA, Lee G, Casanova JL, Studer L. Capturing the biology of disease severity in a PSC-based model of familial dysautonomia. Nat Med. 2016 Dec;22(12):1421-1427. doi: 10.1038/nm.4220. Epub 2016 Nov 14.

Wang Q, Zou Y, Nowotschin S, Kim SY, Li QV, Soh CL, Su J, Zhang C, Shu W, Xi Q, Huangfu D, Hadjantonakis AK, Massagué J. The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells. Cell Stem Cell. 2017 Jan 5;20(1):70-86. doi: 10.1016/j.stem.2016.10.002. Epub 2016 Nov 23.

Vera E, Bosco N, Studer L. Generating Late-Onset Human iPSC-Based Disease Models by Inducing Neuronal Age-Related Phenotypes through Telomerase Manipulation. Cell Rep. 2016 Oct 18;17(4):1184-1192. doi: 10.1016/j.celrep.2016.09.062.

Sultan KT, Han Z, Zhang XJ, Xianyu A, Li Z, Huang K, Shi SH. Clonally Related GABAergic Interneurons Do Not Randomly Disperse but Frequently Form Local Clusters in the Forebrain. Neuron. 2016 Oct 5;92(1):31-44. doi: 10.1016/j.neuron.2016.09.033.

Dardenne E, Beltran H, Benelli M, Gayvert K, Berger A, Puca L, Cyrta J, Sboner A, Noorzad Z, MacDonald T, Cheung C, Yuen KS, Gao D, Chen Y, Eilers M, Mosquera JM, Robinson BD, Elemento O, Rubin MA, Demichelis F, Rickman DS. N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer. Cancer Cell. 2016 Oct 10;30(4):563-577. doi: 10.1016/j.ccell.2016.09.005.

Hicks MJ, Chiuchiolo MJ, Ballon D, Dyke JP, Aronowitz E, Funato K, Tabar V, Havlicek D, Fan F, Sondhi D, Kaminsky SM, Crystal RG. Anti-Epidermal Growth Factor Receptor Gene Therapy for Glioblastoma. PLoS One. 2016 Oct 6;11(10):e0162978. doi: 10.1371/journal.pone.0162978. eCollection 2016.

Zimmer B, Piao J, Ramnarine K, Tomishima MJ, Tabar V, Studer L. Derivation of Diverse Hormone-Releasing Pituitary Cells from Human Pluripotent Stem Cells. Stem Cell Reports. 2016 Jun 14;6(6):858-872. doi: 10.1016/j.stemcr.2016.05.005.

Zhu Z, Li QV, Lee K, Rosen BP, González F, Soh CL, Huangfu D. Genome Editing of Lineage Determinants in Human Pluripotent Stem Cells Reveals Mechanisms of Pancreatic Development and Diabetes. Cell Stem Cell. 2016 Jun 2;18(6):755-68. doi: 10.1016/j.stem.2016.03.015. Epub 2016 Apr 28.

Mansilla-Soto J, Riviere I, Boulad F, Sadelain M. Cell and Gene Therapy for the Beta-Thalassemias: Advances and Prospects.  Hum Gene Ther. 2016 Apr;27(4):295-304. doi: 10.1089/hum.2016.037.

Tan X, Liu WA, Zhang XJ, Shi W, Ren SQ, Li Z, Brown KN, Shi SH. Vascular Influence on Ventral Telencephalic Progenitors and Neocortical Interneuron Production. Dev Cell. 2016 Mar 21;36(6):624-38. doi: 10.1016/j.devcel.2016.02.023.

Fattahi F, Steinbeck JA, Kriks S, Tchieu J, Zimmer B, Kishinevsky S, Zeltner N, Mica Y, El-Nachef W, Zhao H, de Stanchina E, Gershon MD, Grikscheit TC, Chen S, Studer L. Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease. Nature. 2016 Mar 3;531(7592):105-9. doi: 10.1038/nature16951

González F, Huangfu D. Mechanisms underlying the formation of induced pluripotent stem cells. Wiley Interdiscip Rev Dev Biol. 2016 Jan-Feb;5(1):39-65. doi: 10.1002/wdev.206.

Drost J, Karthaus WR, Gao D, Driehuis E, Sawyers CL, Chen Y, Clevers H. Organoid culture systems for prostate epithelial and cancer tissue. Nat Protoc. 2016 Feb;11(2):347-58. doi: 10.1038/nprot.2016.006.

Satlin MJ, Vardhana S, Soave R, Shore TB, Mark TM, Jacobs SE, Walsh TJ, Gergis U. Impact of Prophylactic Levofloxacin on Rates of Bloodstream Infection and Fever in Neutropenic Patients with Multiple Myeloma Undergoing Autologous Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2015 Oct;21(10):1808-14. doi: 10.1016/j.bbmt.2015.06.017.

Wiesner T, Lee W, Obenauf AC, Ran L, Murali R, Zhang QF, Wong EW, Hu W, Scott SN, Shah RH, Landa I, Button J, Lailler N, Sboner A, Gao D, Murphy DA, Cao Z, Shukla, et al. Alternative transcription initiation leads to expression of a novel ALK isoform in cancer. Nature. 2015 Oct 15;526(7573):453-7. doi: 10.1038/nature15258.

Dreser N*, Zimmer B*, Dietz C, Sügis E, Pallocca G, Nyffeler J, Meisig J, Blüthgen N, Berthold MR, Waldmann T, Leist M. Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling. Neurotoxicology. 2015 Sep;50:56-70. doi: 10.1016/j.neuro.2015.07.008. *both authors contributed equally.

Vera E, Studer L. When rejuvenation is a problem: challenges of modeling late-onset neurodegenerative disease. Development. 2015 Sep 15;142(18):3085-9. doi: 10.1242/dev.120667. Review.

Zhu Z, Verma N, González F, Shi ZD, Huangfu D. A CRISPR/Cas-Mediated Selection-free Knockin Strategy in Human Embryonic Stem Cells. Stem Cell Reports. 2015 Jun 9;4(6):1103-11. doi: 10.1016/j.stemcr.2015.04.016.

Studer L, Vera E, Cornacchia D. Programming and Reprogramming Cellular Age in the Era of Induced Pluripotency. Cell Stem Cell. 2015 Jun 4;16(6):591-600. doi: 10.1016/j.stem.2015.05.004.

Perna F, Vu LP, Themeli M, Kriks S, Hoya-Arias R, Khanin R, Hricik T, Mansilla-Soto J, Papapetrou EP, Levine RL, Studer L, Sadelain M, Nimer SD. The polycomb group protein L3MBTL1 represses a SMAD5-mediated hematopoietic transcriptional program in human pluripotent stem cells. Stem Cell Reports. 2015 Apr 14;4(4):658-69. doi: 10.1016/j.stemcr.2015.02.003. Epub 2015 Mar 5.

Bangs FK, Schrode N, Hadjantonakis AK, Anderson KV. Lineage specificity of primary cilia in the mouse embryo. Nat Cell Biol. 2015 Feb;17(2):113-22. doi: 10.1038/ncb3091.

Hicks MJ, Funato K, Wang L, Aronowitz E, Dyke JP, Ballon DJ, Havlicek DF, Frenk EZ, De BP, Chiuchiolo MJ, Sondhi D, Hackett NR, Kaminsky SM, TabarV, Crystal RG. Genetic modification of neurons to express bevacizumab for local anti-angiogenesis treatment of glioblastoma. Cancer Gene Ther. 2015 Jan;22(1):1-8. doi: 10.1038/cgt.2014.58.

Funato K, Major T, Lewis PW, Allis CD, Tabar V. Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation. Science. 2014 Dec 19;346(6216):1529-33. doi: 10.1126/science.1253799.

Zhu Z, González F, Huangfu D. The iCRISPR platform for rapid genome editing in human pluripotent stem cells. Methods Enzymol. 2014;546:215-50. doi: 10.1016/B978-0-12-801185-0.00011-8.

González F*, Zhu Z*, Shi ZD, Lelli K, Verma N, Li QV, Huangfu D. * co-first authors. An iCRISPR platform for rapid, multiplexable, and inducible genome editing in human pluripotent stem cells. Cell Stem Cell. 2014 Aug 7;15(2):215-26. doi: 10.1016/j.stem.2014.05.018.

Sisnaiske J, Hausherr V, Krug AK, Zimmer B, Hengstler JG, Leist M, van Thriel C. Acrylamide alters neurotransmitter induced calcium responses in murine ESC-derived and primary neurons. Neurotoxicology. 2014 Jul;43:117-26. doi: 10.1016/j.neuro.2014.03.010.

He M, Subramanian R, Bangs F, Omelchenko T, Liem KF Jr, Kapoor TM, Anderson KV. The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment. Nat Cell Biol. 2014 Jul;16(7):663-72. doi: 10.1038/ncb2988.

Di Stefano, B, Sardina, JL, van Oevelen, C, Collombet, S, Kallin, EM, Vicent, GP, Lu, J, Thieffry, D, Beato, M, and Graf, T. C/EBPalpha poises B cells for rapid reprogramming into induced pluripotent stem cells. Nature. 2014 Feb 13;506(7487):235-9. doi: 10.1038/nature12885.

Mondal, AM, Horikawa, I, Pine, SR, Fujita, K, Morgan, KM, Vera, E, Mazur, SJ, Appella, E, Vojtesek, B, Blasco, MA, et al. p53 isoforms regulate aging-and tumor-associated replicative senescence in T lymphocytes. J Clin Invest. 2013 Dec;123(12):5247-57. doi: 10.1172/JCI70355.

Miller, JD, Ganat, YM, Kishinevsky, S, Bowman, RL, Liu, B, Tu, EY, Mandal, PK, Vera, E, Shim, JW, Kriks, S, et al. Human iPSC-based modeling of late-onset disease via progerin-induced aging. Cell Stem Cell. 2013 Dec 5;13(6):691-705. doi: 10.1016/j.stem.2013.11.006.

van Oevelen, C, Kallin, EM, and Graf, T. Transcription factor-induced enhancer modulations during cell fate conversions. Curr Opin Genet Dev. 2013 Oct;23(5):562-7. doi: 10.1016/j.gde.2013.07.003.

Vera E, Bernardes de Jesus B, Foronda M, Flores JM, Blasco MA. Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity. PLoS One. 2013; 8(1):e53760. doi: 10.1371/journal.pone.0053760.

Gao, P, Sultan, KT, Zhang, XJ, and Shi, SH. Lineage-dependent circuit assembly in the neocortex. Development. 2013 Jul;140(13):2645-55. doi: 10.1242/dev.087668.

Miura, P, Shenker, S, Andreu-Agullo, C, Westholm, JO, and Lai, EC. Widespread and extensive lengthening of 3’ UTRs in the mammalian brain. Genome Res. 2013 May;23(5):812-25. doi: 10.1101/gr.146886.112.

Dai, Q, Andreu-Agullo, C, Insolera, R, Wong, LC, Shi, SH, and Lai, EC. BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells. Development. 2013 May;140(9):1892-902. doi: 10.1242/dev.087502.

Gonzalez, F, Georgieva, D, Vanoli, F, Shi, ZD, Stadtfeld, M, Ludwig, T, Jasin, M, and Huangfu, D. Homologous recombination DNA repair genes play a critical role in reprogramming to a pluripotent state. Cell Rep. 2013 Mar 28;3(3):651-60. doi: 10.1016/j.celrep.2013.02.005.

Vera E, Bernardes de Jesus B, Foronda M, Flores JM, Blasco MA. The rate of increase of short telomeres predicts longevity in mammals. Cell Rep. 2012 Oct 25; 2(4):732-7. doi: 10.1016/j.celrep.2012.08.023. [PMID:23022483].

Bernardes de Jesus B, Vera E, Schneeberger K, Tejera AM, Ayuso E, Bosch F, Blasco MA. Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer. EMBO Mol Med. 2012 Aug;4(8):691-704. doi: 10.1002/emmm.201200245.

Vera E, Blasco MA. Beyond average: potential for measurement of short telomeres. Aging (Albany NY). 2012 Jun;4(6):379-92.

Elvsåshagen T, Vera E, Boen E, Bratlie J, Andreassen OA, Josefsen D, Malt UF, Blasco MA, Boye B. The load of short telomeres is increased and associated with lifetime number of depressive episodes in bipolar II disorder. J Affect Disord. 2011 Dec;135(1-3):43-50. doi: 10.1016/j.jad.2011.08.006.

Andreu-Agullo C, Maurin T, Thompson CB, Lai EC. Ars2 maintains neural stem-cell identity through direct transcriptional activation of Sox2. Nature. 2011 Dec 25;481(7380):195-8. doi: 10.1038/nature10712.