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The Maura Lab is an energetic, highly collaborative, in-person team that combines clinical, computational, and molecular biology—leveraging bulk and single-cell genomics and close MSKCC clinical partnerships—to uncover genomic drivers of lymphoproliferative disorders and translate them into earlier detection and more personalized treatments.

… The Maura Lab integrates clinical, computational, and molecular biology to understand lymphoproliferative disorders. In particular, we identify genomic and immune drivers for initiation, progression, and treatment response. Using bulk and single-cell sequencing approaches, we develop strategies for early

Cancer biologist Andrea Ventura studies DNA structural rearrangements and non-coding RNAs in cancer and development.

… We use a combination of in vivo, in vitro, biochemical, and computational approaches to investigate various aspects of human cancer and development. Three broad biological domains we are currently exploring include extrachromosomal circular DNAs (ecDNAs), chromosomal rearrangements, and non-coding RNAs

Cancer biologist Hans-Guido Wendel pursues both disease-centered and basic discovery research. The disease focus is on lymphocyte malignancies and the basic science arm of the lab explores fundamental mechanisms that control aberrant mRNA translation programs in cancer. Work in these two research areas frequently intersects in surprising ways.

… Our goal is to develop new cancer therapeutics and we are curious to identify biological vulnerabilities in cancer cells that provide opportunities for attack. Our research explores the molecular and cellular changes that drive cancer cells and ways to create new types of therapeutics including small

Joan Massagué studies the control of stem cell growth and phenotype in tumor progression, metastasis, and response to therapy.

… The Massagué lab investigates metastasis stem cells and their stromal niches throughout the metastatic cascade, with a growing interest in the dormant phase of metastasis. We are defining the phenotypic plasticity and evolution of metastatic cell populations from dormancy to outbreak, identifying drug

The Li lab studies the brain-immune circuits that regulate systemic and brain immunity.

… The Li Lab studies how brain circuits control immunity. Precisely calibrated inflammation is essential for organismal health. The central nervous system continuously monitors internal state and, through hard-wired pathways, can rapidly tune immune function. Our work centers on a brain–immune axis capable