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Molecular biologist John Petrini investigates the repair of chromosomal breaks and the activation of the DNA-damage-induced cell-cycle checkpoints.

… Work in our laboratory is focused on understanding the molecular transactions that govern chromosome stability and replication. The association of cancer predisposition and other pathology with mutations that affect chromosomal metabolism forms the basis of our interest in this process. In this regard

The Taylor laboratory studies the influence of the nervous system on pediatric and young adult cancers.

… Our laboratory studies neuron-cancer interactions, with a focus on developmental malignancies. Using a multi-disciplinary approach within the emerging field of cancer neuroscience, we leverage neuroscience tools and techniques to interrogate the microenvironmental influence of neural circuitry on pediatric

Physician-scientist Viviane Tabar focuses on stem cells as tools for brain repair and for modeling brain cancer.

… I am a neurosurgeon-scientist and Chair of the Department of Neurosurgery. I have clinical expertise in the surgical management of brain tumors such as complex gliomas, meningiomas, and skull base tumors. The lab is focused on two major themes: harnessing the potential of human pluripotent stem cells

The Kushal Dey lab focuses on developing machine learning models and computational pipelines that integrate genomic and epigenomic data.

… The Kushal Dey Lab builds statistical and machine learning models that integrate genetic and genomic data to prioritize variants, genes, and cell types, and to decode the causal functional architecture underlying heritable complex diseases — including immune-related diseases, like Alzheimer’s and inflammatory

The Łuksza Lab develops predictive models of immune-driven evolution to understand how tumors and viruses adapt under immune pressure.

… The Łuksza Lab develops predictive models of immune-driven evolution to understand how tumors and viruses adapt under immune pressure. By integrating concepts from information theory, machine learning, statistical physics, and quantitative immunology, the lab builds computational frameworks to quantify

The Long laboratory investigates the molecular mechanisms of ion channels and enzymatic membrane proteins and seeks to use these discoveries to benefit humanity.

… Our laboratory uses a combination of structural biology and biophysical techniques to discover how ion channels and membrane-embedded enzymes function at the atomic level. The proteins we study are crucial for the function of the immune system, vision, cell differentiation, and embryonic development,

Physician-scientist Luke R.G. Pike studies the mechanistic underpinnings of brain metastasis and seeks to identify translational correlates with outcomes following local or systemic therapy.

… The Luke Pike Lab seeks to understand the unique biology of brain metastasis (BrM) and to improve outcomes for patients afflicted with this terrible disease. BrM is an exceptionally common form of solid tumor metastasis, affecting approximately 400,000 U.S. cancer patients each year. The mechanisms by

Molecular pathologist Marc Ladanyi studies the molecular pathogenesis of sarcomas, lung cancer, and mesothelioma.

… The research program in this laboratory focuses on the genomics and molecular pathogenesis of sarcomas and thoracic malignancies, with an emphasis on clinical translation of potential diagnostic markers and therapeutic targets. Dr. Ladanyi also co-directs (with Chris Sander) the Genome Data Analysis

The Lito lab investigates the properties of oncoproteins that drive cancer cell growth, with a focus on cancers driven by RAS mutations.

… The Lito lab investigates the properties of oncoproteins that drive cancer cell growth, with a focus on cancers driven by RAS mutations. RAS mutants were historically thought to be locked in an active state due to an inability to break down the nucleotide GTP. Contrary to this long-held view, we discovered

Led by Dr. Irene Orlow, the Lab participates in self-initiated research and supports investigations from the Population Sciences & Clinical Research programs that involving human specimens processing, testing, and banking. For additional information on current research, publications, and presentations by the Lab, and more, scroll down and click on the ‘View Lab Overview’ or ‘Current Projects’ links.

…   The Molecular Epidemiology Laboratory Led by Dr. Irene Orlow, the Lab participates in self-initiated research and supports investigations from the Population Sciences & Clinical Research programs that involve handling and testing human specimens. For additional information on current research, publications