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The Lito lab investigates the properties of oncoproteins that drive cancer cell growth, with a focus on cancers driven by RAS mutations.

… The Lito lab investigates the properties of oncoproteins that drive cancer cell growth, with a focus on cancers driven by RAS mutations. RAS mutants were historically thought to be locked in an active state due to an inability to break down the nucleotide GTP. Contrary to this long-held view, we discovered

Physician-scientist Babak Mehrara studies the regulation of lymphatic regeneration after surgery and development of lymphedema.

… Our research group focuses on the lymphatic system in three different pathological settings: lymphedema, obesity, and cancer. Chronic lymphedema is a morbid disease condition without any cure. Our first goal is to uncover the pathology behind development and progression of cancer-related secondary lymphedema

The Antonsecu lab focuses on translocation-associated sarcoma pathogenesis and generating in vitro models.

… An on-going focus of our work is the genomic investigation of pediatric and young adult unclassified mesenchymal tumors, with a special emphasis on detecting novel gene fusions drivers. By applying highly efficient RNAseq and FusionSeq pipelines for novel translocation discovery in tumors that lack known

Xinbo Yang’s lab applies structural biology and protein engineering to decode T cell receptor specificity in cancer and autoimmune disease.

… The Xinbo Yang lab is interested in studying the T cell receptor (TCR) specificity in cancer and autoimmune disease. The patrolling T cells constantly scan host tissues to eliminate infected or malignant cells. Failure to recognize such cells leads to pathogen evasion or cancer. Whereas mis-recognizing

The Chiosis lab uses a unique chemical biology approach to understand, diagnose, and treat cellular processes associated with chronic molecular stress, with the ultimate goal of developing novel therapeutic options for use in the clinic.

… The goal of my program is to investigate stressor maladaptation mechanisms such as they occur in several diseases. Our approach takes advantage of the way nature has evolved to control such stressors, and that is by a unique usage of the chaperome, referred here as the epichaperome. The epichaperome,

The Taylor laboratory studies the influence of the nervous system on pediatric and young adult cancers.

… Our laboratory studies neuron-cancer interactions, with a focus on developmental malignancies. Using a multi-disciplinary approach within the emerging field of cancer neuroscience, we leverage neuroscience tools and techniques to interrogate the microenvironmental influence of neural circuitry on pediatric

Molecular biologist John Petrini investigates the repair of chromosomal breaks and the activation of the DNA-damage-induced cell-cycle checkpoints.

… Work in our laboratory is focused on understanding the molecular transactions that govern chromosome stability and replication. The association of cancer predisposition and other pathology with mutations that affect chromosomal metabolism forms the basis of our interest in this process. In this regard

The Lareau Lab synthesizes computational and experimental genomics methods to study how immune cells in our bodies adapt, expand, differentiate, and evolve over an individual’s lifetime.

… The focus of the Lareau Lab is to understand how cells in our bodies adapt, expand, and evolve during the course of our lives, particularly in the immune system. The theme of our lab’s research is Computational and Translational Immunology, which is purposefully broad but grounds our research program

Developmental biologist Luis F. Parada uses genetically engineered mouse models to study neurofibromatosis, brain tumors, cancer stem cells, and tumor progression.

… The Parada lab uses genetically engineered mouse models to recapitulate and study human disease. These mouse strains are used to understand the natural history of tumors of the nervous system, including glioblastoma multiforme (GBM), malignant peripheral nerve sheath tumors (MPNST), neurofibromas, and

Physician-scientist David Solit studies human oncology and pathogenesis, genomics, oncogenes and tumor suppressors, cancer therapeutics, and clinical trials.

… Our research is based on the underlying hypothesis that the ability to inhibit an oncogenic pathway and block cancer growth will vary based on cell lineage and the complement of mutations within the tumor. To design rational therapeutic studies, we must define not only the spectrum of genetic changes