Human Oncology & Pathogenesis Program

The David Solit Lab

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Research

Pictured: David Solit
David B. Solit, MD
Director, Marie-Josée & Henry R. Kravis Center for Molecular Oncology

Our research is based on the underlying hypothesis that the ability to inhibit an oncogenic pathway and block cancer growth will vary based on cell lineage and the complement of mutations within the tumor. To design rational therapeutic studies, we must define not only the spectrum of genetic changes within particular tumor types but also the mechanisms by which these alterations support tumor growth, survival, metastasis, and other hallmarks of cancer.

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Research Projects

The David Solit Lab

Featured News

Announcement
Christina Leslie and John Petrini
Expanding the Impact of Precision Medicine to Fuel Discoveries

MSK’s Functional Genomics Initiative will enable basic scientists to take full advantage of the massive amount of data produced by tumor sequencing.
Finding Clues in Genes of ‘Exceptional Responders’

Physician-scientist David Solit was interviewed about exceptional responders, patients who defy all expectations by responding dramatically to a drug t...
Event
A student asks a question at last year’s "Major Trends” seminar.
A Sneak Preview of Our Annual “Major Trends” Seminar Live Webcast

Every year, MSK gives high school students and their teachers the opportunity to learn about cutting-edge biomedical research from our scientists.

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Publications

Xing F, Persaud Y, Pratilas CA, Taylor BS, Janakiraman M, She QB, Gallardo H, Liu C, Merghoub T, Hefter B, Dolgalev I, Viale A, Heguy A, De Stanchina E, Cobrinik D, Bollag G, Wolchok J, Houghton A, Solit DB. Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring (V600E)BRAF. Oncogene. 2012 Jan 26;31(4):446-57. doi: 10.1038/onc.2011.250. Epub 2011 Jul 4.

Poulikakos PI, Persaud Y, Janakiraman M, Kong X, Ng C, Moriceau G, Shi H, Atefi M, Titz B, Gabay MT, Salton M, Dahlman KB, Tadi M, Wargo JA, Flaherty KT, Kelley MC, Misteli T, Chapman PB, Sosman JA, Graeber TG, Ribas A, Lo RS, Rosen N, Solit DB. RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature. 2011 Nov 23;480(7377):387-90. doi: 10.1038/nature10662.

Hanrahan AJ, Schultz N, Westfal ML, Sakr RA, Giri DD, Scarperi S, Janakiraman M, Olvera N, Stevens EV, She QB, Aghajanian C, King TA, Stanchina Ed, Spriggs DR, Heguy A, Taylor BS, Sander C, Rosen N, Levine DA, Solit DB. Genomic complexity and AKT dependence in serous ovarian cancer. Cancer Discov. 2012 Jan;2(1):56-67. doi: 10.1158/2159-8290.CD-11-0170.

Misale S, Yaeger R, Hobor S, Scala E, Janakiraman M, Liska D, Valtorta E, Schiavo R, Buscarino M, Siravegna G, Bencardino K, Cercek A, Chen CT, Veronese S, Zanon C, Sartore-Bianchi A, Gambacorta M, Gallicchio M, Vakiani E, Boscaro V, Medico E, Weiser M, Siena S, Di Nicolantonio F, Solit D, Bardelli A. Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer. Nature. 2012 Jun 28;486(7404):532-6. doi: 10.1038/nature11156. 

Iyer G, Hanrahan AJ, Milowsky MI, Al-Ahmadie H, Scott SN, Janakiraman M, Pirun M, Sander C, Socci ND, Ostrovnaya I, Viale A, Heguy A, Peng L, Chan TA, Bochner B, Bajorin DF, Berger MF, Taylor BS, Solit DB. Genome sequencing identifies a basis for everolimus sensitivity. Science. 2012 Oct 12;338(6104):221. doi: 10.1126/science.1226344. Epub 2012 Aug 23.

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People

Pictured: David Solit

David B. Solit, MD

Director, Marie-Josée & Henry R. Kravis Center for Molecular Oncology

  • Physician-scientist David Solit studies human oncology and pathogenesis, genomics, oncogenes and tumor suppressors, cancer therapeutics, and clinical trials.
  • MD, University of Pennsylvania
[email protected]
Email Address
View physician profile
Physician profile

Members

Alexis M. Jones, MS
Alexis M. Jones

Research Lab Manager

Amanda Sabel

Research Technician

Aphrothiti Hanrahan, PhD
Aphrothiti Hanrahan

Assistant Lab Member

Arijh Elfatih Elzein

Research Fellow

Gopa Iyer, MD
Gopa Iyer

Assistant Attending, Genitourinary Oncology Service

Keshia Pierre

Program Assistant

Kwanghee Kim
Kwanghee Kim

Assistant Attending Biologist

James Rodrigues

Senior Research Technician

Naryan Rustgi

Senior Research Technician

Sizhi Paul Gao
Sizhi Paul Gao

Senior Research Scientist

Jessica (Ziyu) Chen

Weill Cornell Graduate Student

Michelle (Xinran) Tang

Weill Cornell Graduate Student

Carissa Chu

Urology Fellow

Song Jiang

Fellow

Wesley Yip

Fellow

Hikmat A. Al-Ahmadie, MD
Hikmat A. Al-Ahmadie

Associate Attending Pathologist, Memorial Hospital

Dilara Akbulut

Research Fellow

Gamze Gokturk Ozcan

Senior Research Scientist

Merve Basar Yerebakan

Senior Research Scientist

Abraham Ari Hakimi
Abraham Ari Hakimi

Assistant Attending, Department of Surgery

Benjamin Davelman

Research Technician

Benjamin Freeman

Medical Student

Eduardo Ankur Mascareno

Research Technician

Hui Jiang
Hui Jiang

Research Scholar

Lynda Vuong

Research Fellow

Sari Khaleel

Urology Fellow

Mark Donoghue, PhD
Mark Donoghue

Associate Director, CMO

Allison Richards, Computational Biologist II
Allison Richards

Lead, CCS Analyst

Anne Marie Noronha
Anne Marie Noronha

Bioinformatics Software Engineer

Hyung Jun Woo
Hyung Jun Woo

Senior Computational Biologist

Martina Bradic
Martina Bradic

Senior Computational Biologist

Samuel Tischfield
Samuel Tischfield

Senior Computational Biologist

Vasilisa Rudneva
Vasilisa Rudneva

Senior Computational Biologist

Vignesh Ravichandran

Senior Computational Biologist

Yixiao Gong
Yixiao Gong

Lead, TEMPO Pipeline

Alexandria Pinto

Computational Biologist

Adam Price

Bioinformatics Software Engineer

Lab Alumni
Shweta Chavan
Shweta Chavan

Senior Computational Biologist

Helen Won, MS
Helen Won

Senior Computational Biologist

Wenhuo Hu, PhD
Wenhuo Hu

Research Associate

Manisha Rao

Research Fellow

Naresh Vasani
Naresh Vasani

Research Assistant

Tripti Shrestha Bhattarai, PhD
Tripti Shrestha Bhattarai

Research Associate

Timothy Clinton

Urology Fellow

Kate Weiss
Kate Weiss

Research Technician

Julian Agin-Liebes
Julian Agin-Liebes

Research Technician

Amber Ahmad

Research Technician

François Audenet
François Audenet

Urologic Oncology Fellow

Aditya Bagrodia
Aditya Bagrodia

Urology Fellow

David Barron, MD, PhD
David Barron

Radiation Oncology Resident

Federica Catalanotti, PhD
Federica Catalanotti

Research Fellow

Eugene K. Cha, MD
Eugene K. Cha

Assistant Attending, Urologic Oncology

Michael Cheng

Fellow

Shawn Dason, Urologic Oncology Fellow
Shawn Dason

Urologic Oncology Fellow

Neil Desai, MD, MHS
Neil Desai

Resident in Radiation Oncology

Noah Friedman, Computational Biologist II
Noah Friedman

Computational Biologist

Rebecca Hiner

Senior Technician

Joseph Hreiki, MD
Joseph Hreiki

Research Fellow

Sumit Isharwal
Sumit Isharwal

Urologic Oncology Fellow

Manickam Janakiraman, PhD
Manickam Janakiraman

Research Associate

Emmet Jordan
Emmet Jordan

Fellow

Philip Kim, MD
Philip Kim

Clinical Research Fellow

Byron Lee

Urology Fellow

Qiang Li
Qiang Li

Urology Fellow

Victor McPherson

Urology Fellow

Moriah Heller Nissan, PhD
Moriah Heller Nissan

Research Fellow

Ricardo Ramirez
Ricardo Ramirez

Cornell University Graduate Student

John Sfakianos
John Sfakianos

Urology Fellow

Tara Soumerai
Tara Soumerai

Assistant Attending, Gynecologic Medical Oncology Service

Brooke Sylvester, PhD
Brooke Sylvester

Research Fellow

Efsevia Vakiani, MD, PhD
Efsevia Vakiani

Assistant Attending Pathologist

Hannah Wise
Hannah Wise

Lead Clinical Data Analyst at Flatiron Health, New York, NY

Feng Xing, PhD
Feng Xing

Research Fellow

Alyssa Yee
Alyssa Yee

Medical Student

Kai Zhang

Graduate Research Assistant

Li Kong, PhD
Li Kong

Research Fellow

Yogindra Persaud
Yogindra Persaud

Research Technician

Lab Affiliations

Achievements

  • Member, American Society for Clinical Investigation (2011)
  • Louise and Allston Boyer Young Investigator Award for Basic Research, Memorial Sloan Kettering Cancer Center (2007)
  • Kimmel Scholar, Sidney Kimmel Foundation for Cancer Research (2007)
  • Career Development Award, American Society of Clinical Oncology (2002)
  • Young Investigator Award, American Society of Clinical (2001)
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  • Doris Duke Translational Award, Doris Duke Foundation (2001)
  • Clinical Scholars Research Fellow, National Institutes of Health (2000)

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

Career Opportunities

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Postdoc Position in Preclinical and Translational Cancer Genomics and Therapeutics

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Get in Touch

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

David B. Solit discloses the following relationships and financial interests:

  • American Association for Cancer Research
    Provision of Services
  • Apple Tree Life Sciences, Inc.
    Provision of Services
  • BridgeBio Inc.
    Provision of Services
  • NovellusDx Ltd.
    Ownership / Equity Interests; Provision of Services
  • Pfizer, Inc.
    Provision of Services
  • Scorpion Therapeutics, Inc.
    Ownership / Equity Interests; Provision of Services
  • Vividion Therapeutics
    Ownership / Equity Interests; Provision of Services

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2021 through disclosure submission in spring 2022). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].


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