Our research is based on the underlying hypothesis that the ability to inhibit an oncogenic pathway and block cancer growth will vary based on cell lineage and the complement of mutations within the tumor. To design rational therapeutic studies, we must define not only the spectrum of genetic changes within particular tumor types but also the mechanisms by which these alterations support tumor growth, survival, metastasis, and other hallmarks of cancer.
David B. Solit, MD
Director, Marie-Josée & Henry R. Kravis Center for Molecular Oncology
Professor
Research Focus
Physician-scientist David Solit studies human oncology and pathogenesis, genomics, oncogenes and tumor suppressors, cancer therapeutics, and clinical trials.Education
MD, University of Pennsylvania- For non-clinical issues only 646-888-2641
- For patient-related issues 646-422-4459
- Lab Phone: 646-888-2649
Lab Members
Amber Ahmad
Research Technician
Hikmat A. Al-Ahmadie
Associate Attending Pathologist, Memorial Hospital
Michael Cheng
Fellow
Shawn Dason
Urologic Oncology Fellow
Arijh Elfatih Elzein
Weill Cornell Graduate School Student
Sizhi Paul Gao
Senior Research Scientist
Aphrothiti Hanrahan
Assistant Lab Member
Wenhuo Hu
Research Associate
Sumit Isharwal
Urologic Oncology Fellow
Gopa Iyer
Assistant Attending, Genitourinary Oncology Service
Alexis M. Jones
Research Assistant
Kwanghee Kim
Senior Research Scientist
Victor McPherson
Urology Fellow
Keshia Pierre
Program Assistant
Efsevia Vakiani
Assistant Attending Pathologist
Naresh Vasani
Senior Research Technician
Hannah Wise
Graduate Student
Kai Zhang
Graduate Research Assistant
Publications
- Xing F, Persaud Y, Pratilas CA, Taylor BS, Janakiraman M, She QB, Gallardo H, Liu C, Merghoub T, Hefter B, Dolgalev I, Viale A, Heguy A, De Stanchina E, Cobrinik D, Bollag G, Wolchok J, Houghton A, Solit DB. Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring (V600E)BRAF. Oncogene. 2012 Jan 26;31(4):446-57. doi: 10.1038/onc.2011.250. Epub 2011 Jul 4.
- Poulikakos PI, Persaud Y, Janakiraman M, Kong X, Ng C, Moriceau G, Shi H, Atefi M, Titz B, Gabay MT, Salton M, Dahlman KB, Tadi M, Wargo JA, Flaherty KT, Kelley MC, Misteli T, Chapman PB, Sosman JA, Graeber TG, Ribas A, Lo RS, Rosen N, Solit DB. RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature. 2011 Nov 23;480(7377):387-90. doi: 10.1038/nature10662.
Affiliations
Selected Achievements
- Member, American Society for Clinical Investigation (2011)
- Louise and Allston Boyer Young Investigator Award for Basic Research, Memorial Sloan Kettering Cancer Center (2007)
- Kimmel Scholar, Sidney Kimmel Foundation for Cancer Research (2007)
- Career Development Award, American Society of Clinical Oncology (2002)
- Young Investigator Award, American Society of Clinical (2001)
