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Radiologist and Nuclear Medicine physician Jan Grimm develops novel approaches for improved diagnosis, monitoring and therapy of prostate and other cancers.

… The Grimm lab in the Molecular Pharmacology Program focuses on the development of novel and innovative approaches for cancer diagnostics and therapy. These approaches evaluate underlying biology and utilize nanotechnology, chemistry and physics interrogated with modern imaging methods. The lab focuses

Physician-scientist Katharine Hsu studies the biology of human natural killer cells and how they contribute to disease processes.

… My laboratory studies the natural killer (NK) cell and the molecules that control its ability to recognize and kill cancer and virally infected cells. Improved understanding of how NK cells behave is critical to advancing our ability to harness their innate capacity for tumor recognition and eradication

My laboratory and clinical research focus on understanding genomics and signaling in colorectal cancer to develop new treatments for patients.

… My laboratory and clinical research focus on understanding genomics and signaling in colorectal cancer to develop new treatments for patients. Colorectal tumors are characterized by a high level of baseline receptor tyrosine kinase (RTK) signaling. Oncogenic inhibition of these tumors, for example with

The Gabrielle Rizzuto lab investigates a long-standing question in immunology: what prevents maternal immune rejection of the placenta and fetus?

… The Gabrielle Rizzuto lab investigates a long-standing question in immunology: what prevents maternal immune rejection of the placenta and fetus? The immune system must be able to discriminate self from non-self. Pregnancy is a beautiful exception to the paradigm that non-self is immunogenic, since the

Computational chemist John Chodera uses statistical mechanics, molecular modeling, and automated biophysical experiments to help identify new potential therapeutics and investigate mechanisms of drug resistance in cancer.

… The Chodera lab uses computation and experiments to develop quantitative, multiscale models of the effects of small molecules on biomolecular macromolecules and cellular pathways. To do this, the group utilizes physical models and rigorous statistical mechanics, with the overall goals of engineering

Physician-scientist Rachel Niec studies how cells and tissues communicate to promote health or drive inflammation and cancer.

… Complex tissue functions, such as nutrient absorption and barrier defense in the intestine, are influenced and tuned by environmental cues and stresses. However, the environmentally tuned cellular interaction networks that define tissue health and resilience or predispose to disease states are poorly

… The Kung Lab leverages patient-driven discovery to identify drivers and therapeutic vulnerabilities in pediatric and young adult cancers. The research infrastructure of the lab bridges the clinic, dry lab, and wet lab, with experimental data derived from model systems as well as in-human studies. We

The Ricardo Otazo lab develops novel magnetic resonance imaging (MRI) techniques for cancer applications including fast imaging, motion tolerant imaging, quantitative imaging of physical tissue parameters, and real-time MRI-guided radiotherapy using advances in MRI acquisition and computational models.

… The Ricardo Otazo lab develops novel magnetic resonance imaging (MRI) techniques for cancer applications including fast imaging, motion resistant imaging, quantitative imaging of physical tissue parameters, and real-time MRI-guided radiotherapy using advances in MRI acquisition and computational models

Physician-scientist Karuna Ganesh studies stem cell plasticity in metastasis, therapy resistance and tissue regeneration.

… Metastasis causes >90% of cancer death.  The emergence, persistence, therapy resistance and lethality of metastatic cancer is driven by dynamic and tenacious metastasis stem cells (MetScs). The Ganesh lab focuses on understanding the molecular mechanisms that underlie the emergence of regenerative plasticity

Dr. Ahmet Dogan is a board-certified pathologist and an internationally recognized leader in hematopathology. His current research interests include lymphoma, plasma cell disorders, and diagnostic techniques for hematopathology such as cytogenetic analysis, genomics, and proteomics. His previous work has contributed much to the understanding of the histogenesis of lymphomas, MALT lymphomas, and T cell lymphomas in particular.

… The Ahmet Dogan lab within the Hematopathology Service establishes new diagnostic approaches and diagnostic test utilization algorithms, which will determine the standard of care for the hematopathology practice. The Service catalogues and analyzes the pathological features of hematological malignancies