Search

The Lai laboratory integrates genetics, biochemistry, and genomewide approaches to study diverse regulatory networks during patterning and behavior.

… As a laboratory of developmental biology, our guiding interest is to comprehend how complex biological patterns can be assembled with stereotyped precision. This requires a detailed understanding of how cells come to execute appropriate behaviors — be it adoption of specific cell fates, proliferation

The Patel laboratory studies the structural biology of macromolecular recognition, regulation and catalysis. Ongoing projects include structure-function studies of the CRISPR-Cas and cGAS-STING surveillance pathways, on the role of Structure Maintenance Chromosome complexes in mediating DNA double strand break repair, on the role of histone and DNA methylation in epigenetic regulation and on RNA-mediated processes ranging from riboswitches and ribozymes to those governing siRNA and piRNA pathways.

… Our group applies structural (cryo-EM, x-ray crystallography and NMR), biochemical and biophysical methods together with functional studies to investigate macromolecular-mediated recognition, regulation and catalysis. The ongoing major projects in the laboratory focus on the structural biology of CRISPR-Cas

Computational biologist Quaid Morris uses artificial intelligence techniques and develops machine learning algorithms to study gene regulation, cancer evolution, clinical informatics, and other topics in systems biology.

… Our lab uses machine learning and artificial intelligence to do biomedical research, focusing on cancer evolution, gene regulation, clinical informatics, and gene function prediction. A key interest is the role of RNA-binding proteins (RBPs) in post-transcriptional regulation. We focus on developing

Physician-scientist Alan Hanash studies transplant immunology and immune-mediated mechanisms of tissue damage and regeneration.

… Alan Hanash is an Associate Member of Memorial Sloan Kettering and an Attending Physician on the Adult Bone Marrow Transplant Service in the Department of Medicine. Dr. Hanash’s research focuses on the immunology of hematopoietic transplantation and immune-mediated mechanisms of tissue damage and regeneration

The laboratory investigates cellular lipid and energy metabolism, in particular the mechanisms and physiology of neutral lipid synthesis and storage in lipid droplets.

… The laboratory investigates cellular lipid and energy metabolism, in particular the mechanisms and physiology of neutral lipid synthesis and storage in lipid droplets. More broadly, the lab studies the mechanisms how cells regulate the abundance of lipids, how they store lipids to buffer fluctuation

Molecular geneticist Britta Weigelt studies the genomics of gynecologic cancers and the use of circulating cell-free DNA for disease monitoring and the identification of therapy resistance mechanisms.

… Gynecology DMT Research Laboratory Our laboratory focuses on the use of high-throughput genomics and functional genomics to identify drivers of rare gynecologic cancer types, and to define the clinical and biological significance of intra-tumor phenotypic and genetic heterogeneity in these tumors. Dr

Immunologist Morgan Huse studies the structure and function of immune cell-cell interactions.

… In the Huse lab, we combine imaging technology with synthetic chemistry and materials science to understand how immune cells communicate. Morgan Huse, PhD Deputy Director for Core Technologies; Member, Immunology Program Professor PhD, The Rockefeller University Achievements Searle Scholar Award (2008

Physician-scientist Ingo Mellinghoff studies signal transduction alterations in primary brain tumors.

… Our laboratory focuses on the study of molecular pathways that regulate brain tumor growth. Our long-term goal is to develop therapeutic paradigms that target specific properties of primary brain tumors, including genetic alterations in cancer signaling pathways, unique aspects of brain tumor metabolism

Physician-scientist Richard Wong studies the mechanisms of cancer cell chemotaxis in perineural invasion.

… Perineural invasion (PNI) is an ominous form of cancer progression in which cancer cells invade and track along nerves. PNI occurs most frequently in cancers that affect highly innervated organs, including pancreatic, head and neck, and prostate cancers. It is associated with increased recurrence and

The Reznik Lab studies metabolic and mitochondrial dysfunction in cancer through analysis of multimodal genetic, metabolomic, and clinical data.

… The Reznik Lab studies metabolic and mitochondrial dysfunction in cancer through analysis of multimodal genetic, metabolomic, and clinical data. We use computational tools to address a basic question: how do tumors adapt their metabolism, the process by which they obtain energy and nutrition from the