Memorial Hospital Research Laboratories
The Britta Weigelt Lab
Gynecology DMT Research Laboratory
Our laboratory focuses on the use of high-throughput genomics and functional genomics to identify drivers of rare gynecologic cancer types, and to define the clinical and biological significance of intra-tumor phenotypic and genetic heterogeneity in these tumors. Dr. Weigelt’s laboratory is devising strategies to overcome the challenges posed by intra-tumor genetic heterogeneity, based on state-of-the-art sequencing analyses of circulating cell free (cf)DNA and of single cells. By bringing together traditional pathological techniques with genetic analyses and functional studies, the Weigelt lab seeks to refine the classification of gynecologic cancers and identify novel drivers and potential therapeutic targets of specific tumor types. In addition, Dr. Weigelt is investigating if cfDNA analysis (so-called “liquid biopsies”) can accurately monitor the disease course of women with endometrial or cervical cancer, and if resistance mechanisms to platinum salts or PARP inhibitors in ovarian cancer patients can be identified in cfDNA.
Identification of recurrent FHL2-GLI2 oncogenic fusion in sclerosing stromal tumors of the ovary. Kim SH, Da Cruz Paula A, Basili T, Dopeso H, Bi R, Pareja F, da Silva EM, Gularte-Mérida R, Sun Z, Fujisawa S, Smith CG, Ferrando L, Martins Sebastião AP, Bykov Y, Li A, Silveira C, Ashley CW, Stylianou A, Selenica P, Samore WR, Jungbluth AA, Zamarin D, Abu-Rustum NR, Helin K, Soslow RA, Reis-Filho JS, Oliva E, Weigelt B. Nat Commun 2020; 11:44. doi: 10.1038/s41467-019-13806-x.
High-Sensitivity Mutation Analysis of Cell-Free DNA for Disease Monitoring in Endometrial Cancer. Ashley CW, Selenica P, Patel J, Wu M, Nincevic J, Lakhman Y, Zhou Q, Shah RH, Berger MF, Da Cruz Paula A, Brown DN, Marra A, Iasonos A, Momeni-Boroujeni A, Alektiar KM, Long Roche K, Zivanovic O, Mueller JJ, Zamarin D, Broach VA, Sonoda Y, Leitao MM, Friedman CF, Jewell E, Reis-Filho JS, Ellenson LH, Aghajanian C, Abu-Rustum NR, Cadoo K, Weigelt B. Clin Cancer Res 2023;29(2):410-421. doi: 10.1158/1078-0432.CCR-22-1134.
Britta Weigelt, PhD
Director, Gynecology DMT Research Laboratory
- Molecular geneticist Britta Weigelt studies the genomics of gynecologic cancers and the use of circulating cell-free DNA for disease monitoring and the identification of therapy resistance mechanisms.
- MD, CM Medicine, McGill University
- Obstetrics & Gynecology Residency Program, University of British Columbia
- Gynecologic Oncology and Clinical Investigator Programs, Université de Montréal
- MSc Biomedical Sciences, Université de Montréal
- MSc Bioinformatics and Modeling, Université Libre de Bruxelles, Belgium
- PhD Biomedical Sciences, Université Libre de Bruxelles, Belgium
- BA (Hon) Neuroscience and Behavior, Vassar College
- MD and Masters in Clinical Research, Icahn School of Medicine at Mount Sinai
- Residency in Obstetrics and Gynecology, Hospital of the University of Pennsylvania
- B.S. Biomedical Engineering, Drexel University
- M.D. Drexel University College of Medicine
- M.Sc. Clinical Epidemiology and Health Services Research, Weill Cornell Graduate School of Medical Sciences
- Residency Obstetrics and Gynecology, Albany Medical Center
- B.S. Biology and Science, Technology, & Society, Tufts University
- BA, Neurobiology and Behavior, Cornell University
- MD, Virginia Commonwealth University School of Medicine
- Internship, Obstetrics and Gynecology, University of Washington
- Residency, Obstetrics and Gynecology, New York Presbyterian- Weill Cornell Medical Center
- BA, Public Health, Johns Hopkins University
- MHS, Biochemistry & Molecular Biology, Johns Hopkins University Bloomberg School of Public Health
- MD, University of Miami Miller School of Medicine
- Residency in OBGYN, NewYork-Presbyterian Weill Cornell Medicine
- BS, Developmental, Cellular and Molecular Biology, University of Washington
- MD, Drexel University College of Medicine
- Obstetrics and Gynecology Residency, NYU School of Medicine
- GYN Oncology Fellowship, Memorial Sloan Kettering Cancer Center
- B.S. Biology, St. John’s University
- M.D. New York University School of Medicine
- International Law with Pre-Medical studies, Georgetown University
- M.D. American University of Beirut, Lebanon
- B.S Biology, Howard University
- BS, Life Science, The Pennsylvania State University
- MD, Sidney Kimmel Medical College at Thomas Jefferson University
- • Gynecologic Surgery and Obstetrics Residency, Walter Reed National Military Medical Center – National Capital Consortium
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Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
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Britta Weigelt discloses the following relationships and financial interests:
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