Full TitleA Phase 2 Trial of Ado-Trastuzumab Emtansine for Patients with HER2 Amplified or Mutant Cancers
Ado-trastuzumab emtansine is used to treat breast cancers that contain too much of an abnormal HER2 protein. The drug binds to HER2 on cancer cell surfaces, and the emtansine breaks off and kills the cancer cell.
In this study, researchers are examining the safety and effectiveness of using ado-trastuzumab emtansine in patients with other cancers fueled by abnormal HER2, including lung, endometrial, colorectal, and bladder cancers. Ado-trastuzumab emtansine is given intravenously (by vein).
To be eligible for this study, patients must meet several criteria, including but not limited to the following:
- Patients must have lung, colorectal, endometrial, bladder, or other cancers whose growth is driven by HER2.
- Patients may have had prior treatment (except for ado-trastuzumab emtansine) and must recover from any side effects before entering the study
- This study is for patients age 18 and older.