A Phase 2 Study of Lymph Node Removal in People With Melanoma

Full Title

Lymph Node Excision (LNEx) for Patients with Stage III Melanoma with One Clinically Positive Node: Excision of Lymph Node Trial [EXCILYNT]

Purpose

Researchers want to see if removing only 1 lymph node with cancer prevents melanoma from coming back in that area. The people in this study have melanoma that spread to just 1 lymph node.

The standard approach to melanoma surgery is to:

• Remove the melanoma
• Take out the lymph node with cancer
• Remove additional lymph nodes around the cancerous lymph node

However, removing multiple lymph nodes can cause side effects such as swelling, pain, and decreased mobility. Doctors hope that removing only the cancerous lymph node works as well as removing multiple nodes for preventing melanoma recurrence.

Who Can Join

To join this study, there are a few conditions. You must:

• Have melanoma that spread to only 1 lymph node.
• Not have had anti-cancer medications within 3 months of entering the study.
• Be able to walk and do routine activities for more than half the time you are awake.
• Be age 18 or older.

Contact

For more information and to see if you can join this study, please call Dr. Edmund Bartlett’s office at 212-639-2448.