Stem Cell Transplant Clinical Trials & Research

Memorial Sloan Kettering’s team approach to transplantation goes beyond the bedside to research in the laboratory. Our investigators have experience in matching people with the right clinical trials that will help them the most.

We have been developing and evaluating promising new ways to do transplants for decades. We created many of the methods that help people who need transplants today. Choosing to have a transplant at MSK may give you access to new treatments before they’re widely available elsewhere.

Our clinical and laboratory researchers are working together to learn more about how healthy immune reactions work and how these can go wrong in people with cancer. We are using that information to be able to offer the latest treatment advances to people who have their transplants at MSK.

Our doctors are leading a large number of clinical trials to test new ways to do stem cell transplants. These research studies are based on our growing understanding of the immune system. Our research is increasingly translational, which means that discoveries made in the lab are taken directly to our patients.

Areas of research include studies of the immune cells called T cells and the role that they play in transplants. In addition, we are look for strategies to reduce complications such as graft-versus-host disease and ways to lower the toxicity of the treatments given before transplants. We are also trying to expand the use of stem cell transplants to treat more diseases.

Learn more about the clinical trials we are currently conducting:

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14 Clinical Trials found
The transplantation of stem cells from umbilical cord blood is a treatment for some blood cancers and non-cancerous blood or metabolic disorders. Patients routinely receive high doses of chemotherapy and sometimes radiation before receiving the stem cells to help make room in the bone marrow for new blood stem cells to grow, prevent the body from rejecting the transplanted cells, and help kill any abnormal blood cells in the body. However, the combination of these treatments can have serious side effects.
To learn more about the purpose of this study and to find out who can join, please click here to visit ClinicalTrials.gov for a full clinical trial description.
Sickle cell disease and beta-thalassemia are blood diseases caused by a genetic change (mutation) in hemoglobin, the protein in red blood cells that carries oxygen throughout the body. People with these diseases may be offered a stem cell transplant. Stem cell transplantation involves receiving healthy blood-forming cells (stem cells) from a donor to replace the diseased or damaged cells in the bone marrow.
Umbilical card blood is rich in healthy, blood-forming cells (stem cells) that are very good at fighting blood cancers. Cord blood transplants (CBT) are a standard treatment for adults with blood cancers who lack a genetically matched stem cell donor. Cord blood is donated by a baby's mother at birth. CBT uses stem cells from cord blood collections to replace cells that have been destroyed by disease or anti-cancer treatment.