Dr. Charles Ryan

Charles James Ryan, MD

Areas of Expertise

Conditions I Treat

  • Prostate cancer and conditions
  • Testicular cancer
Request an Appointment
Our Care Advisors can answer many of your questions. They will connect you with the best healthcare provider for your needs.

Get to Know Me

I am a genitourinary medical oncologist who specializes in treating prostate cancer, especially prostate cancer at an advanced stage that has spread, or metastasized, to other parts of the body. I see patients at the Sidney Kimmel Center for Prostate and Urologic Cancers in New York City and at Memorial Sloan Kettering Monmouth in New Jersey.

I take pride in getting to know my patients and their families and educating them about their diagnosis. I also take the time to explain the various treatment options available for prostate cancer, including hormonal therapies, chemotherapy, targeted therapy, and radiogland therapy – a type of treatment that delivers radiation directly to targeted cancer cells. As a lifelong clinician, I look forward to establishing long-term relationships with my patients.

I also engage in research and have led many clinical trials and research teams that focus on the biology, treatment, and supportive care for prostate cancer. In the past, I have received research funding from the National Institutes of Health, the Department of Defense Prostate Cancer Research Program, and the Prostate Cancer Foundation.

I have published more than 200 articles and chapters in the world’s leading medical journals. I am the author of the book, The Virility Paradox: The Vast Influence of Testosterone on Our Bodies, Minds, and the World We Live In. In the past, I have served as Chair of the National Cancer Institute’s GU Steering Committee’s Prostate Cancer Task Force and as Chief Executive Officer of the Prostate Cancer Foundation. I serve as Medical Director of the Prostate Cancer Clinical Trials Consortium, and I am a member of the Advanced Prostate Cancer Consensus Conference.

What I Do at MSK

I'm a genitourinary (GU) medical oncologist, which is a cancer doctor who specializes in genitourinary (jeh-nih-toh-YOOR-ih-nayr-ee) cancers. This includes bladder, kidney, penis, prostate, and testicular cancers.

  • Attending Physician
Areas of Expertise

Conditions I Treat

  • Prostate cancer and conditions
  • Testicular cancer
Education & Honors

Education

  • BA, Marquette University
  • MD, University of Wisconsin

Residencies

  • University of Wisconsin Hospitals and Clinics

Fellowships

  • Medical Oncology, Memorial Sloan Kettering Cancer Center

Board Certifications

  • Medical Oncology

Awards and Honors

  • Fellowship Research Mentor Award, University of Minnesota (2021)
  • Director's Service Award, National Cancer Institute (2018)
  • Marc A Shuman Mentoring Award, University of California (2017)
  • Fellowship Program Mentor Award, University of California (2011)
  • Commitment to Patient Care Award, University of California (2008)

Insurance Information

Understanding your insurance options is an important part of managing your cancer care. We have relationships with many common healthcare providers and plans.

Don't see your carrier or plan? We can help you understand your coverage.

If you don't have health insurance or are worried that your care may not be fully covered, our financial assistance programs may be able to help.

If you have questions about insurance, call us at 646-497-9176.

Make an Appointment

Current Patients
Request an appointment by logging in to MSK MyChart or calling your Care Team. If you are not enrolled in MSK MyChart, ask your Care Team to send you an invitation. You can also go to MSK MyChart and select “Sign up now.”

Contact and Location

Dr. Ryan sees patients at two locations.

Location
Middletown, NJ
New York, NY
480 Red Hill Road Middletown NJ 07748

Looking to see a doctor at a different location? See all MSK locations.

Colleagues

Doctors at Memorial Sloan Kettering work as teams, with specialists from all different areas. This allows us to consider all your needs together, and to give you the best possible care.

See all Genitourinary Oncology Service doctors

Clinical Trials

Smiling doctors in the lab
Find a Clinical Trial for You

Memorial Sloan Kettering's doctors and scientists are constantly developing new treatments for cancer. MSK is typically running hundreds of clinical trials at a given time.

You may be able to participate in a clinical trial even if you are new to MSK. Search our online directory to find trial information and see more about who can participate.

Search clinical trials

Research and Publications

Bergom HE, Boytim E, McSweeney S, Sadeghipour N, Elliott A, Passow R, Toye E, Li X, Likasitwatanakul P, Geynisman DM, Dehm SM, Halabi S, Sharifi N, Antonarakis ES, Ryan CJ, Hwang J. Androgen production, uptake, and conversion (APUC) genes define prostate cancer patients with distinct clinical outcomes. JCI Insight. 2024 Aug 29:e183158. doi: 10.1172/jci.insight.183158. Epub ahead of print. PMID: 39207857.

Ryan CJ, Smith MR, de Bono JS, Molina A, Logothetis CJ, de Souza P, Fizazi K, Mainwaring P, Piulats JM, Ng S, Carles J, Mulders PF, Basch E, Small EJ, Saad F, Schrijvers D, Van Poppel H, Mukherjee SD, Suttmann H, Gerritsen WR, Flaig TW, George DJ, Yu EY, Efstathiou E, Pantuck A, Winquist E, Higano CS, Taplin ME, Park Y, Kheoh T, Griffin T, Scher HI, Rathkopf DE; COU-AA-302 Investigators. Abiraterone in metastatic prostate cancer without previous chemotherapy. N Engl J Med. 2013 Jan 10;368(2):138-48. doi: 10.1056/NEJMoa1209096. Epub 2012 Dec 10. Erratum in: N Engl J Med. 2013 Feb 7;368(6):584. PMID: 23228172; PMCID: PMC3683570.

Ryan CJ, Smith MR, Fizazi K, Saad F, Mulders PF, Sternberg CN, Miller K, Logothetis CJ, Shore ND, Small EJ, Carles J, Flaig TW, Taplin ME, Higano CS, de Souza P, de Bono JS, Griffin TW, De Porre P, Yu MK, Park YC, Li J, Kheoh T, Naini V, Molina A, Rathkopf DE; COU-AA-302 Investigators. Abiraterone acetate plus prednisone versus placebo plus prednisone in chemotherapy-naive men with metastatic castration-resistant prostate cancer (COU-AA-302): final overall survival analysis of a randomised, double-blind, placebo-controlled phase 3 study. Lancet Oncol. 2015 Feb;16(2):152-60. doi: 10.1016/S1470-2045(14)71205-7. Epub 2015 Jan 16. PMID: 25601341.

Morris MJ, Molina A, Small EJ, de Bono JS, Logothetis CJ, Fizazi K, de Souza P, Kantoff PW, Higano CS, Li J, Kheoh T, Larson SM, Matheny SL, Naini V, Burzykowski T, Griffin TW, Scher HI, Ryan CJ. Radiographic progression-free survival as a response biomarker in metastatic castration-resistant prostate cancer: COU-AA-302 results. J Clin Oncol. 2015 Apr 20;33(12):1356-63. doi: 10.1200/JCO.2014.55.3875. Epub 2015 Jan 26. PMID: 25624432; PMCID: PMC4881370.

Ryan CJ, Molina A, Li J, Kheoh T, Small EJ, Haqq CM, Grant RP, de Bono JS, Scher HI. Serum androgens as prognostic biomarkers in castration-resistant prostate cancer: results from an analysis of a randomized phase III trial. J Clin Oncol. 2013 Aug 1;31(22):2791-8. doi: 10.1200/JCO.2012.45.4595. Epub 2013 Jul 1. PMID: 23816964; PMCID: PMC5569674.

Publications on PubMed

Visit PubMed for a full listing of Dr. Ryan’s journal articles. Pubmed is an online index of research papers and other articles from the US National Library of Medicine and the National Institutes of Health.

See all on PubMed