Matthias A. Karajannis, MD, MS
Chief, Pediatric Neuro-Oncology Service
Pediatric Brain and Spinal Cord Tumors; Peripheral Nerve Sheath Tumors; Langerhans Cell Histiocytosis, Neurofibromatosis
New Patient Appointments
Scheduling a visit is easy. Click below or call us to get started.
Accepted Insurance Providers
Dr. Karajannis accepts the following list of insurance providers. Select your insurance provider to see more details.
Memorial Sloan Kettering is an in-network provider with Aetna HMO, POS, and PPO plans. Aetna does not include us in any of the plans you can purchase through the insurance exchanges or through Medicare. Please ask your insurance if you need a one-time referral.
Blue Cross Blue Shield
In New York State
Memorial Sloan Kettering is an in-network provider with Empire Blue Cross Blue Shield (Wellpoint) of New York HMO, EPO, PPO, and POS plans, with the following exceptions:
- Empire Blue Cross Blue Shield does not include us in any of the plans you can buy through the insurance exchanges.
- Memorial Sloan Kettering is not an in-network provider for Empire's Medicare Managed Care plan known as Mediblue).
- The Empire Indemnity Plan provides limited coverage for our services.
Memorial Sloan Kettering is a designated Center of Excellence by Blue Cross Blue Shield.
In New Jersey
Memorial Sloan Kettering is an in-network provider with some Horizon Blue Cross Blue Shield of New Jersey plans for individuals, families, and small businesses. For example, the PPO plan is in-network with our Manhattan locations.
Horizon Blue Cross HMO is only in-network with our Basking Ridge, Bergen and Monmouth locations. It does not allow access to our Manhattan facilities.
Horizon Blue Cross PPO is in network with our Basking Ridge, Bergen, Monmouth and Manhattan locations.
OMNIA Plans: Tier I EPO based plan policy is only in-network with our Basking Ridge, Bergen and Monmouth locations and does not allow access to our Manhattan sites. Tier II EPO is only in-network with our Manhattan sites if it is a blue-card plan (there would be a suitcase logo indicating PPO on the front of the card).
Other plans may only be in-network at our Basking Ridge, Bergen or Monmouth locations.
Outside New York State and New Jersey
Some, but not all, Blue Cross Blue Shield plans outside of New York and New Jersey include Memorial Sloan Kettering as an in-network provider. Contact your insurance to find out if your plan provides in-network access to Memorial Sloan Kettering.
Memorial Sloan Kettering is an in-network provider with CIGNA's HMO, POS, and PPO plans. CIGNA does not include us in any of the plans you can buy through the insurance exchanges.
- If you are a New York State resident: Please ask your insurance if you need a one-time referral.
- If you live outside of New York State: Please ask your insurance if you have in-network access to Memorial Sloan Kettering.
Memorial Sloan Kettering is a designated Center of Excellence by Blue Cross Blue Shield.
EmblemHealth (including GHI, HIP, ConnectiCare, and Vytra)
Memorial Sloan Kettering is an in-network provider with EmblemHealth’s PPO, EPO, POS, and HMO plans as well as their Enhanced Care Prime Network, which supports Medicaid Managed Care and Child Health Plus and Medicare plans. Memorial Sloan Kettering is also in-network with the New York State Essential Emblem Health plan, which can be purchased on the insurance exchange. Emblem Health does not include us in any of its Medicare plans or in any of its Select Care network plans. You must bring a referral from your Emblem primary care doctor to your first appointment.
Empire Blue Cross Blue Shield Health Plus
Formerly known as Health Plus Amerigroup, Empire Blue Cross Blue Shield Health Plus is an in-network provider with Memorial Sloan Kettering. You will need a one-time referral from your primary care doctor.
Health Insurance Exchanges
We understand that there may be many complexities involved with insurance coverage purchased through the health exchange network of the Affordable Care Act. We're here to help. If you have questions about how your care will be covered by an insurance provider, or need help navigating a change in coverage, please call us at 646-227-3378; if you are not a resident of New York, you can call us at 866-248-1274. Our team is here to listen to your concerns and assist you in any way we can. We want our care to be as accessible and affordable for as many people as possible.
Memorial Sloan Kettering is an in-network provider with HealthSmart’s Accel, HSPC, and HPO networks.
Memorial Sloan Kettering is a designated Center of Excellence by Humana.
Interlink Health Services
Memorial Sloan Kettering is a designated Center of Excellence by Interlink Health Services.
Memorial Sloan Kettering is a designated Center of Excellence by Lifetrac.
Memorial Sloan Kettering is an in-network provider for all MagnaCare health plans except those products you can buy through the insurance exchanges.
New York State Medicaid covers physician and hospital services at Memorial Sloan Kettering. Patients are responsible for co-payments.
We also have contractual relationships involving Medicaid Managed Care plans. MSK is an in-network provider with Medicaid NY Emblem Health (formerly known as HIP) and Medicaid NY Empire Blue Cross Blue Shield HealthPlus (formerly known as Amerigroup). You will need a one-time referral from your primary care doctor.
In New York: Memorial Sloan Kettering’s New York locations are in-network with the Emblem
In New Jersey: Memorial Sloan Kettering’s New Jersey locations in Basking Ridge, Bergen and Monmouth are in-network with the Horizon Medicare Advantage Plan. This plan is not accepted for care provided at MSK’s New York locations.
If you are enrolled in any other Medicare Advantage plan, please contact your insurance carrier to determine your benefits and coverage at Memorial Sloan Kettering since your access may be limited.
Memorial Sloan Kettering is an in-network provider with some Multiplan/Beech Street/PHCS plans. Contact your insurance carrier to find out if your plan provides in-network access to Memorial Sloan Kettering.
Memorial Sloan Kettering is a designated Center of Excellence by Multiplan.
Multiple Insurance Plans
If you are covered by more than one insurance plan, you will want to determine your benefits from both plans. First, you need to determine which one is your primary insurance provider by contacting your employee benefits office or your insurance carriers. After you find out which is your primary insurance provider, you should then contact your insurance carrier to determine if you have access to Memorial Sloan Kettering.
Memorial Sloan Kettering is an in-network provider with some MVP plans. Contact your insurance carrier to find out if your plan provides in-network access to Memorial Sloan Kettering.
New York State Employee Health Insurance Plan (Empire Plan)
Memorial Sloan Kettering is an in-network provider for New York State employees who have enrolled in UnitedHealthcare's Cancer Resource Services. If you have the Empire Plan, you should call Cancer Resources Services at 866-936-6002 to verify and enroll in this coverage.
Memorial Sloan Kettering is in-network with Oscar's Circle Plus Network, a part of its Small Group Broad line that is offered only to select small business groups. Oscar does not include Memorial Sloan Kettering as an in-network provider for any of its individual plans. Please confirm eligibility with your insurance carrier.
Other Coverage Options
We have agreements with several insurance companies that may provide additional coverage for cancer patients. These benefit programs include:
- AXA Assistance USA
- Beech Street
- Integrated Health Plans
- National Health Administrators
- National Preferred Provider Network
- UnitedHealthcare's Cancer Resource Services
- United Resource Network
- Veterans Choice Program
Memorial Sloan Kettering is an in-network provider with Oxford’s Freedom and Liberty plans as well as the Metro Plan (which is only offered to small business groups and no longer offered as individual plans). Please confirm with your insurance if you need a one-time referral. Note: Oxford's Medicare Managed Care plan — Secure Horizon — does not include Memorial Sloan Kettering as an in-network provider. Oxford does not include us in any of the plans you can buy through the insurance exchanges.
Memorial Sloan Kettering is an in-network provider with QualCare's PPO and HMO/POS network.
Specialty Care Management
Memorial Sloan Kettering is a designated Center of Excellence by Specialty Care Management.
Memorial Sloan Kettering is an in-network provider with UnitedHealthCare's HMO, POS, and PPO plans. Please confirm with your insurance if a one-time referral is needed.
UnitedHealthCare's Medicare Managed Care plan does not include Memorial Sloan Kettering as an in-network provider.
United does not include us in any of the plans you can buy through the insurance exchanges.
Memorial Sloan Kettering is a designated Center of Excellence by UnitedHealthcare.
World Trade Center Health Program
Memorial Sloan Kettering is an in-network provider with the World Trade Center Health Program.
Contact and Location
Find a Convenient Location
Memorial Sloan Kettering has locations throughout New York City, Long Island, New Jersey, and Westchester. These locations offers many services, including screening, chemotherapy, and medical testing.
MS, New York University School of Medicine; MD, Free University Berlin
Pediatrics – Duke University Medical Center
Pediatric Hematology/Oncology – Memorial Sloan Kettering Cancer Center; Pediatric Neuro-Oncology – Memorial Sloan Kettering Cancer Center
General Pediatrics; Pediatric Hematology/Oncology
I am a pediatric neuro-oncologist who has cared for children with brain tumors, spinal cord tumors, and neurofibromatosis for 11 years. As Chief of Neuro-Oncology Service Service at Memorial Sloan Kettering, I feel privileged to be a part of a community of the most dedicated clinicians and scientists in the world. We are all committed to our young patients with brain tumors and driven to accelerate progress in the way we diagnose and care for them.
I went to medical school during a time when rapid progress was made in treating children with cancer using chemotherapy, particularly in children with leukemia. I witnessed the power of combining interdisciplinary collaboration, laboratory research, and careful clinical research to turn once-deadly diseases into curable conditions. After completing pediatric residency training and a fellowship in pediatric hematology/oncology, I decided to pursue additional training in pediatric neuro-oncology. I realized that despite progress, many children with brain tumors still had poor prognoses and were in urgent need of new, more-effective, and less-toxic therapies.
At MSK, we have the most skilled and experienced medical and surgical specialists, who are experts in caring for children with brain tumors. We rely on each other, first and foremost, to make the most accurate and precise diagnoses. Because of recent advancements in our molecular diagnostics capabilities, we have the unprecedented ability to distinguish brain tumors that may look the same under the microscope but have very different clinical behavior and treatment requirements. These advancements also allow us to identify vulnerabilities in individual tumors that may be treatable with molecularly targeted drugs. This is called precision medicine and holds tremendous potential for treating subsets of our patients.
Once we establish a diagnosis, our team of experts — together with the patient and his or her family — creates a personalized treatment plan. These range from careful observation for some patients with low-grade or benign tumors to aggressive therapies using many different treatments, possibly including surgery, chemotherapy, radiation therapy, and/or immunotherapy. We also take into consideration the wide array of clinical trials for children with brain tumors offered at MSK and incorporate them into care plans whenever possible. For each patient, our goal is to achieve the best possible outcomes while minimizing any toxic effects of treatment.
My research translates findings from the laboratory into better ways to diagnose and treat children and young adults with brain tumors. I am currently the principal investigator of several early-phase clinical trials for patients with neurofibromatosis, with the goal of finding new treatment strategies for this inheritable condition that predisposes people to multiple nervous-system tumors. I am also actively involved as an investigator in cooperative clinical trial groups such as the Children’s Oncology Group and the Pediatric Brain Tumor Consortium.
I recognize that a cancer diagnosis is perhaps the most difficult and challenging time in the life of a child and his or her family, and I know that each situation is unique. To that end, all patients and families should know that we have a team of experts who will be with them throughout the entire experience — from diagnosis through treatment and into long-term follow up care. We are a team, and we are here to make sure that our patients have the best possible outcomes.
Doctors at Memorial Sloan Kettering work as teams, with specialists from all different areas. This allows us to consider all your needs together, and to give you the best possible care.
Clinical Trials Investigated by Dr. Karajannis
- A Phase II Study of Veliparib plus Radiation Therapy in Patients with Newly Diagnosed High-Grade Glioma
Clinical Trials Co-Investigated by Dr. Karajannis
- A Phase I Study of APX005M Immunotherapy in Pediatric Patients with Persistent or Recurrent Brain Tumors and Newly Diagnosed Brain Stem Glioma
Find a Clinical Trial for You
Memorial Sloan Kettering's doctors and scientists are constantly developing new treatments for cancer. MSK is typically running hundreds of clinical trials at a given time.
You may be able to participate in a clinical trial even if you are new to MSK. Search our online directory to find trial information and see more about who can participate.
Research and Publications
Publications on PubMed
Visit PubMed for a full listing of Dr. Karajannis’s journal articles. Pubmed is an online index of research papers and other articles from the US National Library of Medicine and the National Institutes of Health.