I am an attending physician on the Infectious Diseases Service of Memorial Hospital and a Member in the Immunology Program of the Sloan Kettering Institute. I’m an incumbent of the Alfred P. Sloan Chair at MSK and also a professor of immunology and microbial pathogenesis, medicine, and molecular biology in the Weill Cornell Graduate School.
As an attending physician on the Infectious Diseases Service, I treat both inpatients and outpatients. My clinical practice encompasses a wide variety of infections, with an emphasis on patients with mycobacterial infections including Mycobacterium tuberculosis, pulmonary disease due to Mycobacterium avium, BCG infections, disseminated mycobacterial infections in immunosuppressed patients, and rapidly growing mycobacterial infections. I also see patients with HIV infection and general infectious disease problems.
My laboratory has elucidated multiple virulence determinants of M. tuberculosis, including the Rip1 pathway of intramembrane proteolysis, cyclopropane modification of mycolic acids, and the CarD RNA polymerase binding protein. We have also made contributions to understanding both innate and adaptive immune recognition of M. tuberculosis, DNA repair pathways of mycobacteria, and protein chaperone function of mycobacteria.
More recently, we have investigated the mechanism of action of Bacillus Calmette-Guerin (BCG) as an immunotherapy of cancer. Finally, I am the co-primary investigator (with Carl Nathan at Weill Cornell) of the Tri-I TBRU, a collaborative translational TB research collaboration that includes the GHESKO center in Haiti and seeks to understand latency and persistence of M. tuberculosis. We have broad interests in basic, translational, and clinical mycobacteriology.
- Clinical Expertise: General Infectious Diseases; HIV/AIDS; Mycobacterial Infections
- Languages Spoken: English
- Education: MD, Columbia University College of Physicians and Surgeons
- Residencies: Massachusetts General Hospital
- Fellowships: Albert Einstein College of Medicine/ Montefiore Medical Center
- Board Certifications: Internal Medicine; Infectious Diseases
As home to one of the world’s top cancer research centers, Memorial Sloan Kettering is typically involved in more than 900 clinical trials at a given time. Currently, clinical trials focused on the conditions I treat are enrolling new patients. If you’re interested in joining a clinical trial, click to learn about the trial’s purpose, eligibility criteria, and how to get more information.Learn more