S. Machele Donat, MD, FACS

S. Machele Donat, MD, FACS


Clinical Expertise

Urologic Oncology; Bladder Cancer; Urethra; Kidney Cancer; Urinary Diversion and Reconstruction

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Accepted Insurance Providers

Dr. Donat accepts the following list of insurance providers. Select your insurance provider to see more details.

Contact and Location

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Find a Convenient Location

Memorial Sloan Kettering has locations throughout New York City, Long Island, New Jersey, and Westchester. These locations offers many services, including screening, chemotherapy, and medical testing.

About Me


MD, University of Oklahoma Health Science Center


University of Oklahoma Health Science Center


Memorial Sloan Kettering Cancer Center

Board Certifications


I am a board-certified urologic surgeon with expertise in treating patients with cancers of the urinary tract, including bladder, urethral, kidney, testis, prostate cancer, and rare cancers such as urethral cancer or genitourinary sarcomas.

When treating patients with superficial bladder cancer, I use conservative therapies and preventive approaches whenever possible. For patients with invasive bladder cancer, I have extensive experience in bladder-sparing surgery, and often use nerve-sparing techniques, which can help preserve sexual and urinary function.

Some patients require an operation to remove the bladder (cystectomy), and I have expertise in urinary reconstructive techniques such as continent urethral diversion (neobladder), in which a new bladder is constructed from a segment of the intestine and connected to the urethra; continent stomal diversion, in which a segment of intestine is used to form a catheterizable pouch; and ileal conduits, in which a segment of the small intestine is used to create a channel through which urine is drained to the skin and into a collection bag.

For patients with kidney cancer, it is often important to preserve kidney function because many have a pre-existing kidney disease, high blood pressure, or diabetes. Whenever possible, I also perform kidney-sparing surgery in patients with renal cell cancers to preserve their renal function, and I am involved in research studies at Memorial Sloan Kettering evaluating ablative therapies, which use heat or cold to destroy tumor cells.

In addition, I am involved in a number of research studies, some of which are examining the role that heredity plays in tumor recurrence and progression in certain forms of bladder cancer. I am also helping to establish a registry of familial and atypical bladder and upper urinary tract cancers at Memorial Sloan Kettering. I am evaluating the effectiveness of several new imaging approaches for diagnosing genitourinary cancers as well as a blood test for detecting metastatic bladder cancer, and I am helping design the protocols that will guide the Center’s acquisition and preservation of tissue, blood, and urine samples; these may be used in future studies on the prevention and treatment of genitourinary cancers. I am also a leader in research studies looking at our ability to minimize postoperative complications, shorten hospital stays for all our major surgical operations, and improve patients’ quality of life following treatment for their genitourinary cancer.


Doctors at Memorial Sloan Kettering work as teams, with specialists from all different areas. This allows us to consider all your needs together, and to give you the best possible care.

Clinical Trials

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Find a Clinical Trial for You

Memorial Sloan Kettering's doctors and scientists are constantly developing new treatments for cancer. MSK is typically running hundreds of clinical trials at a given time.

You may be able to participate in a clinical trial even if you are new to MSK. Search our online directory to find trial information and see more about who can participate.

Research and Publications

Publications on PubMed

Visit PubMed for a full listing of Dr. Donat’s journal articles. Pubmed is an online index of research papers and other articles from the US National Library of Medicine and the National Institutes of Health.