This information explains the signs of immune effector cell-associated neurotoxicity syndrome (ICANS). It also explains what to do if your loved one has symptoms of ICANS.
What is ICANS?
ICANS stands for immune effector cell-associated neurotoxicity syndrome. ICANS is sometimes called neurotoxicity syndrome.
ICANS is a temporary side effect of CAR T cell therapy and similar cancer treatments. It affects the brain and can change how a person thinks, talks, or acts.
What are the signs and symptoms of ICANS?
- Confusion or memory problems
- Trouble writing
- Changes in behavior
- Headaches
- Shaking or tremors
- Being sleepier than usual
What caregivers should do
If your loved one has signs or symptoms of ICANS:
- Stay calm and stay with your loved one. Do not leave them alone, especially if their symptoms are getting worse.
- Write down their symptoms and when they started.
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Call Cellular Therapy at 646-608-3150 if:
- The patient has any of these symptoms for the first time.
- These symptoms are getting worse.
The Cellular Therapy care team will tell you what to do.
When to call 911
Call 911 if the patient:
- Is suddenly confused or disoriented (does not know what’s going on around them).
- Has trouble speaking or slurred speech.
- Is very hard to wake up.
- Has a seizure (uncontrolled shaking or stiffening of their body).
Do not transport the patient without Emergency Medical Services (EMS) support.
Ask EMS to take you and the patient to the nearest hospital. When you arrive, tell a staff member that the patient is a cellular therapy patient.
Learn more
Read About Cytokine Release Syndrome (CRS) and Neurotoxicity Syndrome to learn more about ICANS.
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