Concizumab

Adult Medication
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This information from Lexicomp® explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider.

Brand Names: US

Alhemo

Brand Names: Canada

Alhemo

What is this drug used for?

  • It is used to prevent and lower the number of bleeding episodes in people who have hemophilia.

What do I need to tell my doctor BEFORE I take this drug?

  • If you are allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
  • If you are taking another drug to help with bleeding like rFVIIa, activated prothrombin complex concentrate (aPCC), factor VIII (FVIII), or factor IX (FIX). Ask your doctor if you are not sure if you are taking another drug to help with bleeding. Talk to your doctor about how to use other drugs for bleeding with this drug if needed.

This is not a list of all drugs or health problems that interact with this drug.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

  • Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists. This drug may need to be stopped before certain types of surgery as your doctor has told you. If this drug is stopped, your doctor will tell you when to start taking this drug again after your surgery or procedure.
  • Have your blood work and other lab tests checked as you have been told by your doctor.
  • This drug may affect certain lab tests. Tell all of your health care providers and lab workers that you take this drug.
  • Do not stop taking this drug without calling the doctor who ordered it for you.
  • Call your doctor right away if you have unexplained bruising or bleeding or if bleeding does not stop after taking this drug. This may be a sign that your normal dose is not working as well.
  • Blood clots have happened with this drug. Tell your doctor if you have ever had a blood clot. Talk with your doctor.
  • Do not share this product with another person. This includes any needles or syringes, even if the needle has been changed. Sharing may pass infections from one person to another. This includes infections you may not know about.
  • This drug may cause harm to an unborn baby. A pregnancy test may be done before you start this drug to show that you are NOT pregnant.
  • If you may become pregnant, use birth control while taking this drug and for 7 weeks after the last dose. If you get pregnant, call your doctor right away.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Dizziness.
  • A fast heartbeat.
  • Cold or pale skin.
  • Feeling confused.
  • Sudden stomach or back pain.
  • Bleeding where the shot is given.
  • Eye pain or swelling.
  • Headache.
  • Call your doctor right away if you have signs of a blood clot like chest, arm, back, neck, or jaw pain or pressure; coughing up blood; numbness or weakness on 1 side of your body; trouble speaking or thinking; change in balance; change in eyesight; shortness of breath; or swelling, warmth, or pain in the leg or arm.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Bruising, itching, pain, redness, swelling, or other reaction where the injection was given.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to your national health agency.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

How is this drug best taken?

Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given as a shot into the fatty part of the skin on the top of the thigh or the belly area.
  • This drug must not be given into a muscle.
  • It is important that you do not miss or skip a dose of this drug during treatment.
  • If you will be giving yourself the shot, your doctor or nurse will teach you how to give the shot.
  • If you have active bleeding, talk with your doctor. Do not start taking this drug while you have active bleeding without first talking to your doctor.
  • Take this drug at the same time of day.
  • Wash your hands before and after use.
  • Attach new needle before each dose.
  • Remove all pen needle covers before injecting a dose (there may be 2). If you are not sure what type of pen needle you have or how to use it, talk with the doctor.
  • This drug is colorless to a faint yellow. Do not use if the solution changes color.
  • Do not use if the solution is cloudy, leaking, or has solid particles.
  • Do not give into skin within 2 inches (5 cm) of the belly button.
  • Do not give into skin that is irritated, tender, bruised, red, scaly, hard, scarred, or has stretch marks.
  • Do not give into a mole.
  • Move the site where you give the shot with each shot.
  • Throw away needles in a needle/sharp disposal box. Do not reuse needles or other items. When the box is full, follow all local rules for getting rid of it. Talk with a doctor or pharmacist if you have any questions.

What do I do if I miss a dose?

  • If you miss a dose during the first 4 weeks of treatment, call your doctor right away. Your doctor will tell you how to restart this drug.
  • If you miss a dose after the first 4 weeks, check the package insert or call the doctor or pharmacist to find out what to do.

How do I store and/or throw out this drug?

  • Store unopened containers in a refrigerator. Do not freeze.
  • Store in the outer carton to protect from light.
  • After opening, store in the refrigerator or at room temperature. Throw away any part not used after 28 days.
  • Do not use if it has been frozen.
  • Store with the pen cap on.
  • Protect from heat and sunlight.
  • Throw away drug if stored at a temperature above 86°F (30°C).
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

General drug facts

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else’s drugs.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • This drug comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time this drug is refilled. If you have any questions about this drug, please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a specific patient. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care provider’s examination and assessment of a patient’s specific and unique circumstances. Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. The use of this information is governed by the Terms of Use, available at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms.

Last Reviewed Date

2025-01-02

Copyright

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Last Updated

Friday, April 14, 2023