Liver Cancer Clinical Trials & Research

Memorial Sloan Kettering has one of the nation’s largest clinical trial programs for people with liver cancer.

We’re on the hunt for answers, continuously conducting research to find agents that improve how we care for people with primary liver disease. Sometimes we can offer you therapies that are not available elsewhere through our clinical trials.

Studying Liver Cancer Stages

Our researchers are evaluating ways of diagnosing and staging primary liver tumors by studying the value of new imaging techniques, including:

  • volumetric CT, which produces visual representations in three dimensions
  • dynamic contrast-enhanced MRI, a technique using rapid imaging and a contrast material that, when combined with ultrasound, makes certain organs, blood vessels, or tumors easier to see
  • nuclear imaging, which produces images of different parts of the body

The Fibrolamellar-Hepatocellular Carcinoma Consortium

We’re determined to improve treatment options for people with the primary liver cancer fibrolamellar-hepatocellular carcinoma (FLL-HCC). We lead a collaborative initiative with colleagues at Johns Hopkins University and the University of California, San Francisco, with the aim of:

  • promoting awareness about FLL-HCC within the cancer community
  • developing new therapies for the disease
  • pooling information on patients in order to document trends in diagnosis, treatment, and survival

Liver Cancer Clinical Trials

Clinical trials test new drugs and drug combinations, surgical techniques, diagnostic technologies, and strategies for preserving quality of life for people undergoing treatment. Our experts can help determine if clinical trials are right for you. The following liver cancer clinical trials at MSK are currently enrolling new patients. To learn more about a study, choose from the list below.

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10 Clinical Trials found
ABBV-324 is a type of drug called an antibody-drug conjugate (ADC). ADCs are composed of an antibody made from a specific cell line chemically linked to a drug. The antibody binds to specific proteins on certain types of cells, including cancer cells. The linked drug enters these cells and destroys them, with a lower risk of harming other cells. ABBV-324 is given intravenously (by vein).
Researchers want to find the best dose of RYZ801 to give with RYZ811 in people with inoperable liver cancer. Inoperable means the cancer cannot be taken out with surgery. The people in this study have hepatocellular carcinoma (HCC) that makes high levels of a liver protein called GPC3.
Researchers want to find the best dose of TTI-101 that can be used safely alone and with other drugs for cancer. The people in this study have hepatocellular carcinoma (liver cancer) that has metastasized (spread) or is inoperable (surgically unremovable).
BNT326 is a type of drug called an antibody-drug conjugate (ADC). ADCs are made of a monoclonal antibody linked to a drug. The antibody binds to a protein on cancer cells called HER3, which plays a role in cancer cell growth. It then releases the anti-cancer drug to kill the cancer cell. By destroying these cells, BNT326 may help slow or stop the growth of your cancer. It is given intravenously (by vein).
Researchers want to find the best dose of ODM-212 to treat advanced solid tumors. The people in this study have solid tumors that have spread and cannot be cured with standard therapies. Examples include:
Researchers are assessing the best dose and benefit of DT2216 given with irinotecan chemotherapy in young people with cancer. DT2216 may help to kill cancer cells by blocking Bcl-xL, a protein that some cancers need to survive. Irinotecan is an anti-cancer drug that is part of the usual treatment for many cancers. Both drugs are given intravenously (by vein).
Casdozokitug blocks an immune system protein called IL-27. By binding to and blocking IL-27, casdozokitug may help immune cells fight cancer. Toripalimab also helps the immune system fight cancer. Bevacizumab prevents the growth of new blood vessels that feed the cancer. All three drugs are given intravenously (by vein).
Researchers are assessing MEDI5752 and AZD2936 with standard treatments in people with cancer. The people in this study have primary liver or biliary cancer, including biliary tract or gallbladder cancer, that spread or cannot be surgically removed (inoperable). In addition, they have not yet received treatment for the cancer.
The purpose of this study is to find the highest dose of the investigational drug codrituzumab that can be given safely in children and young adults with solid tumors that came back or continued to grow despite treatment. Codrituzumab works by targeting a protein called GPC3, which can drive the growth of some forms of cancer that affect children and young adults. It is given intravenously (by vein).
To learn more about the purpose of this study and to find out who can join, please click here to visit ClinicalTrials.gov for a full clinical trial description.