Clinical Updates & Insights

Our clinical updates provide you with timely information about Memorial Sloan Kettering’s new treatment approaches, key clinical trials, and innovations in detecting and treating many cancers.

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233 Clinical Updates found
Tumor Hypoxia: A Clinical Biomarker of Distant Metastasis Risk after Chemoradiotherapy for Head and Neck Cancer
Tumor Hypoxia: A Clinical Biomarker of Distant Metastasis Risk after Chemoradiotherapy for Head and Neck Cancer

Tumor hypoxia on 18F-fluoromisonidazole (FMISO) positron emission tomography (PET) may serve as a reliable clinical biomarker of distant metastasis risk for patients with head and neck squamous cell carcinoma (HNSCC) after chemoradiotherapy (CRT), according to a study by MSK researchers.
Expanding Active Surveillance Eligibility for Patients with Intermediate-Risk Prostate Cancer
Expanding Active Surveillance Eligibility for Patients with Intermediate-Risk Prostate Cancer

Evidence from a recent study, led by MSK urologic surgeon, Behfar Ehdaie, MD, MPH, indicates that more patients with favorable Grade Group 2 prostate cancer can be successfully managed with active surveillance and achieve acceptable oncologic outcomes, even if later treatment is required.
MSK Research Team Identifies New, Rare Type of Small Cell Lung Cancer
MSK Research Team Identifies New, Rare Type of Small Cell Lung Cancer

A Memorial Sloan Kettering Cancer Center (MSK) research team has identified a new, rare type of small cell lung cancer (SCLC) — dubbed “atypical SCLC” — that primarily affects younger people who have never smoked.
Physician working in laboratory
MSK Researchers Report Exciting Cancer Research Advances at ESMO Congress 2024

Memorial Sloan Kettering Cancer Center (MSK) experts shared the results from cutting-edge advances in cancer research at the European Society of Medical Oncology (ESMO) Congress 2024, held in Barcelona, Spain, September 13 to 17, 2024.
Select Patients with Seminoma Metastatic to the Retroperitoneum May Safely Avoid Chemotherapy and Radiation with primary RPLND
Select Patients with Seminoma Metastatic to the Retroperitoneum May Safely Avoid Chemotherapy and Radiation with Primary RPLND

A Q&A with MSK Urologic Surgeon Richard Matulewicz, MD, MSCI, MS.
A New Endpoint for Accelerated Approvals in Multiple Myeloma
A New Endpoint for Accelerated Approvals in Multiple Myeloma

MSK played a central role in the U.S. Food and Drug Administration (FDA) Oncologic Drugs Advisory Committee (ODAC)’s landmark decision in April 2024 to accept measurable residual disease (MRD) as an intermediate clinical endpoint for accelerated approval of new drugs and new indications in multiple myeloma clinical trials.
The Main Cause of Non-Relapse Mortality after CAR T Cell Therapy is Not What You Think
Post-Transplantation Prophylaxis Resulted in Similar Outcomes for Mismatched and Matched Donor Stem Cell Transplants

According to a large retrospective study co-led by Memorial Sloan Kettering Cancer Center and published in the Journal of Clinical Oncology, PTCy is an acceptable alternative to CNI-based prophylaxis in MUD HCT recipients and superior for MMUD HCT. These results will help improve minority donor participation in the NMDP registry.
The Main Cause of Non-Relapse Mortality after CAR T Cell Therapy is Not What You Think
The Main Cause of Non-Relapse Mortality after CAR T Cell Therapy is Not What You Think

A recent study led by investigators at MSK and published in Nature Medicine, included a comprehensive analysis of non relapse mortality after CAR T cell therapy in patients with lymphoma and multiple myeloma across multiple clinical trials and real-world studies. In this Q&A we discuss the study's key findings and a new tool for assessing infection risk prior to CAR T cell therapy.
E-Nose Technology Detects Early-Stage Lung Cancer with High Reliability in MSK-Exclusive Trial
E-Nose Technology Detects Early-Stage Lung Cancer with High Reliability in MSK-Exclusive Trial

Electronic nose (e-nose) technology identified early-stage lung cancer with high reliability in a prospective observational clinical trial conducted at Memorial Sloan Kettering Cancer Center (MSK).
MSK ASCO 2024 Research Roundup: Practice-Changing Advances in Head and Neck Cancer, Tenosynovial Giant Cell Tumor, Kidney Cancer, Lung Cancer, and More Add to Default shortcuts
MSK ASCO 2024 Research Roundup: Practice-Changing Advances in Head and Neck Cancer, Tenosynovial Giant Cell Tumor, Kidney Cancer, Lung Cancer, and More

MSK physician-scientists presented breakthrough advances in new treatment approaches for several cancer types at the 2024 ASCO Annual Meeting.