More About Cellular Therapeutics Center Minus iconIcon indicating subtraction, or that the element can be closed. Plus IconIcon indicating addition, or that the element can be opened. Arrow (down) icon.An arrow icon, usually indicating that the containing element can be opened and closed.

Mission and Goals

The Cellular Therapeutics Center at MSK has specific goals, including: 

  • to responsibly and safely conduct clinical trials of tumor-targeted T cells for the treatment of both hematological and solid tumor malignancies.
  • to assess and optimize safety of chimeric antigen receptor (CAR) T cell therapies as well as understand the mechanisms associated with observed toxicities.
  • to design and conduct first-in-human clinical trials utilizing genetically modified T cells based on novel discoveries made in the laboratory at MSK including the development of novel CAR vectors and combination therapies with small molecules or monoclonal antibodies.
  • to study clinical data from clinical trials to assess biomarkers of response and mechanisms of resistance to CAR T cells.
  • to develop a multidisciplinary program focused on the clinical development of cell-based therapies for cancer with an emphasis on CAR T cells.
  • to train personnel to help develop multidisciplinary CAR T cell programs at academic medical centers and participate in multicenter CAR T cell trials.
  • to advance the field of adoptive cellular therapy.