More Information: Minus iconIcon indicating subtraction, or that the element can be closed. Plus IconIcon indicating addition, or that the element can be opened. Arrow (down) icon.An arrow icon, usually indicating that the containing element can be opened and closed.

Elisa de Stanchina, PhD

Facility Head

Office Phone


Office Fax


Lab Phone




Manchado E, et al. (2016) “A combination strategy for treating KRAS mutant lung cancer”. Nature 534:647-51

Rodrik-Outmezguine VS, et al (2016). “Overcoming mTOR Resistance Mutations with a New Generation mTOR Inhibitor”. Nature 534:272-6

Malladi S, et al. (2016).  “Metastatic Latency and Immune Evasion Mediated by Autocrine DKK1”. Cell 165:45-60

Fattahi F, et al. (2016). “Pluripotent-derived human enteric neuron lineage for combined cell and drug-based therapy in Hirschsprung’s disease”. Nature 531:105-9

LaFave LM, et al. (2015) “Loss of BAP1 function leads to EZH2-dependent transformation”. Nat Med 21:1344-9

Yao Z, et al. (2015). “BRAF mutants evade ERK dependent feedback by different mechanisms that determine their sensitivity to drugs.” Cancer Cell 28:370-83

Shih AH, et al. (2015). “Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia”. Cancer Cell 27:502-15

Maddalo D, et al. (2014). “In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system”. Nature 516: 423-7.

Schwartz S, et al. (2014). Feedback suppression of PI3Kα signaling in PTEN negative tumors is relieved by selective inhibition of PI3Kβ. Cancer Cell  27:109-22.

Lovly CM, et al. (2014). “Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer.” Nat Med. 20:1027-34

Huang CH, et al. (2014). “CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma”. Genes Dev. 15:1800-14

Wolfe A, et al. (2014). “RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer”. Nature 513: 65-70 PMID: 25079319

Clohessy JG and de Stanchina E (2013). “Infrastructure needs for translational integration of mouse and human trials”. Mouse Models of Cancer, CSHL Press: 461-66.

Piovan E, et al. (2013). “Direct Reversal of Glucocorticoid Resistance by AKT Inhibition in Acute Lymphoblastic Leukemia”. Cancer Cell 24:766-76

Lito P, et al. (2012). “Relief of profound feedback inhibition of mitogenic signaling by Raf inhibitors attenuates their activities in BRAFV600E melanomas”. Cancer Cell 22:668-82

Zammarchi F, et al. (2011). “Anti-tumorigenic potential of STAT3 alternative splicing modulation”. Proc. Natl. Acad. Sci.USA 108-17779-84

Real PJ, et al. (2009). “Gamma-secretase inhibitors reverse glucocorticoid resistance in T-ALL”. Nature Med. 15: 50-58.