The Caov-4 cell line is an ovarian cancer cell line with epithelial morphology that grows in adherent culture. These cells harbor a loss-of-function mutation in the p53 gene and are sensitive to cisplatin.
This cell line was established from a metastatic site (fallopian tube) in a 45-year-old Caucasian female with adenocarcinoma of the ovary.
Jorgen Fogh, PhD, formerly at Sloan Kettering Institute, Memorial Sloan Kettering
Yaginuma Y et al. (1992) Abnormal structure and expression of the p53 gene in human ovarian carcinoma cell lines. Cancer Research 52: 4196-4199 (PubMed ID: 1638534)
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