SK-MEL-1 is the first of a series of melanoma cell lines established from patient-derived tumor samples. This cell line is grown in suspension culture and expresses mutant B-Raf (V600E) and wildtype N-Ras.
This cell line was established in 1966 from a metastatic site (thoracic lymph duct) in a 29-year-old Caucasian male with malignant melanoma.
Herbert F. Oettgen, MD, formerly at Sloan Kettering Institute, Memorial Sloan Kettering
- Oettgen HF et al. (1968) Suspension culture of a pigment-producing cell line derived from a human malignant melanoma. Journal of the National Cancer Institute 41: 827-843 (Pubmed ID: 4879578)
- Fogh J et al. (1977) One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. Journal of the National Cancer Institute 59: 221-226 (PubMed ID: 327080)
- Xing F et al. (2012) Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring (V600E) BRAF. Oncogene 31(4):446-457 (PubMed ID: 21725359)
This cell line may be licensed nonexclusively for research or commercial purposes.
For internal research purposes by a commercial entity: Utilize MSK’s Express License, available here. In order to streamline and expedite the licensing of select MSK cell lines, the terms of this non-exclusive license are non-negotiable. Please note: This license is only available for select cell lines, including this one.
To proceed, please download this contract, fill in all relevant fields, and email a scanned version to Alexandra Buga at firstname.lastname@example.org. Once this license has been executed by MSK, you will receive a signed copy and invoice, and can then place your order with ATCC.
For non-licensing requests from academic-research institutions: Contact Frances Weis-Garcia, PhD, Associate Laboratory Member/Head, Antibody & Bioresource Core Facility, MSK, 646-888-2354, email@example.com.