SK-MEL-1 is the first of a series of melanoma cell lines established from patient-derived tumor samples. This cell line is grown in suspension culture and expresses mutant B-Raf (V600E) and wildtype N-Ras.
This cell line was established in 1966 from a metastatic site (thoracic lymph duct) in a 29-year-old Caucasian male with malignant melanoma.
Herbert F. Oettgen, MD, formerly at Sloan Kettering Institute, Memorial Sloan Kettering
- Oettgen HF et al. (1968) Suspension culture of a pigment-producing cell line derived from a human malignant melanoma. Journal of the National Cancer Institute 41: 827-843 (Pubmed ID: 4879578)
- Fogh J et al. (1977) One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. Journal of the National Cancer Institute 59: 221-226 (PubMed ID: 327080)
- Xing F et al. (2012) Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring (V600E) BRAF. Oncogene 31(4):446-457 (PubMed ID: 21725359)
This cell line may be licensed nonexclusively for research or commercial purposes.
- For licensing requests: Alexandra Buga, MBA, Business Development Analyst, Office of Technology Development, MSK, 646-888-1078, firstname.lastname@example.org
- For non-licensing requests from academic-research institutions: Frances Weis-Garcia, PhD, Associate Laboratory Member/Head, Antibody & Bioresource Core Facility, MSK, 646-888-2354, email@example.com