SK-MM-1: Human Multiple Myeloma Cell Line

SK 440

SK-MM-1: Human Multiple Myeloma Cell Line

SK 440

Description

SK-MM-1 is a multiple myeloma cell line that grows in suspension culture. These cells display plasmacytoid morphology and have a doubling time of approximately 32 hours. SK-MM-1 cells do not express the Epstein-Barr virus nuclear antigen. These cells express the pan-B-cell marker B1 and the late B-cell/plasma cell marker BL3, but do not express any T-lymphocyte, myeloid, or early B-lymphocyte markers. SK-MM-1 cells secrete kappa light chains, but do not secrete any heavy chains.

Source

This cell line was established in 1981 from immature plasma cells in the bone marrow of a 51 year-old male, of unknown ethnicity, with plasma cell leukemia.

Inventors

Alan N. Houghton, MD, Attending Physician, Department of Medicine, Memorial Hospital; and Member, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center

Key References

Eton O et al. (1989) Establishment and characterization of two human myeloma cell lines secreting kappa light chains. Leukemia 3: 729-735 (PubMed ID: 2506399)

Licensing Information

This cell line may be licensed nonexclusively for research or commercial purposes.

Contact Information

  • For licensing requests: Alexandra Buga, MBA, Business Development Analyst, Office of Technology Development, MSK, 646-888-1078, bugaa@mskcc.org
  • For non-licensing requests from academic-research institutions: Frances Weis-Garcia, PhD, Associate Laboratory Member/Head, Antibody & Bioresource Core Facility, MSK, 646-888-2354, weisgarf@mskcc.org

Stage of Development

Ready to use

Indications