SK-LU-1 is a lung adenocarcinoma cell line that displays epithelial morphology and grows in adherent culture. This cell line expresses mutant K-Ras (G12D) and has homozygous deletions in the CDH6 and CDKN2A genes. These cells do not express the enzyme telomerase reverse transcriptase (hTERT) and consequently lack telomerase activity. This correlates with significantly reduced tumorigenicity in vitro and in vivo. These cells, however, display characteristics of alternative telomere lengthening (ALT) mechanisms (i.e., heterogeneity of telomere lengths and the presence of distinct nuclear structures called ALT-associated promyelocytic leukemia bodies). The SK-LU-1 cells do not form tumors when injected into immunocompromised mice.
This cell line was established in 1969 from a 60-year-old Caucasian female with adenocarcinoma of the lung.
Chester M. Southam, MD, formerly at Sloan Kettering Institute, Memorial Sloan Kettering
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- Brachner A et al. (2006) Telomerase- and alternative telomere lengthening-independent telomere stabilization in a metastasis-derived human non-small cell lung cancer cell line: effect of ectopic hTERT. Cancer Research 66: 3584-3592 (PubMed ID: 16585183)
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