SK-RC-21 is a metastatic renal cancer cell line derived from the lumbar vertebra which grows in soft agar and has a doubling time of 38 hours.
This cell line is part of a collection of renal cell carcinoma (RCC) cell lines derived from metastatic sites of patients who underwent surgery.
This cell line was established from a 59-year-old male of unknown ethnicity with renal cell carcinoma.
All cell lines were established in Dr. Lloyd Old’s laboratory, from patients undergoing nephrectomy at Memorial Hospital, MSK, between the years 1972 and 1987. Fresh surgical specimens were obtained from Tumor Procurement Services, Department of Surgical Pathology, Memorial Hospital, MSK.
Lloyd J. Old, MD, former William E. Snee Chair in Cancer Immunology, MSK; former Director, New York Branch, Ludwig Institute for Cancer Research, and members of the Old Laboratory
- Brodaczewska K et al. (2016) Choosing the right cell line for renal cell cancer research. Molecular cancer, 15(1), 83. (PubMed ID: 27993170)
- Ebert T et al. (1990) Establishment and characterization of human renal cancer and normal kidney cell lines. Cancer research, 50(17), 5531-5536. (PubMed ID: 2386958)
- Ueda R. et al. (1981) Cell surface antigens of human renal cancer defined by mouse monoclonal antibodies: identification of tissue-specific kidney glycoproteins. Proceedings of the National Academy of Sciences of the United States of America, 78(8), 5122-5126. (PubMed ID: 6946460)
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