Inside My Lab: Adrienne Boire

My laboratory focuses on metastasis to the central nervous system (CNS), both leptomeningeal and parenchymal metastases. We employ multiple complementary approaches to identify and target cancer cell adaptations to the challenging microenvironmental constraints posed by the CNS.

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Adrienne A. Boire, MD, PhD

Adrienne A. Boire, MD, PhD

Assistant Professor

Research Focus

Physician-scientist Adrienne Boire studies metastasis to the central nervous system.


  • PhD, Tufts University, Boston, MA
  • MD, University of Chicago, Chicago, IL

Lab Members

  • Boire A, Zou Y, Shieh J, Macalino D, Pentsova E and J Massagué. 2017 Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis. Cell 168(6):1101-1113.
  • Chen Q, Boire A**, Jin X, Valiente M, Er EE, Lopez-Soto A, Patwa R, Shah H, Xu K, Cross JR and J Massagué. 2016 Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer. Nature 533(7604):493-8. **Co-first author
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Selected Achievements
  • Vienna Medical Academy Award (2017)
  • Damon Runyon Clinical Investigator Award (2017)
  • Arnold P. Gold Foundation Humanism and Excellence in Teaching Award (2012)
  • Pew Biomedical Scholar (2018)
  • Pershing Square Sohn Prize (2019)