Memorial Hospital Research Laboratories

The Aimee Crago Lab


Aimee Crago, MD, PhD
Aimee Crago, MD, PhD

The rarity of soft tissue sarcomas has historically made the definition of genomic drivers of their initiation and progression difficult.  Through copy number, whole exome and transcriptome analyses, however, common events associated with these lesions have recently been defined.  The focus of our laboratory is to understand how these events, in the context of a mesenchymal cell background, promote sarcomagenesis.  Using in vitro and in vivo techniques, we hope to use this information to identify novel predictive markers and therapeutic targets with potential to inform patient care.

Research Projects

Publications Highlights

Chmielecki J*, Crago AM*, Rosenberg M, O’Connor R, Walker SR, Ambrogio L, Auclair D, McKenna A, Heinrich MC, Frank DA, Meyerson M (*equal contribution). Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors. Nature Genetics Feb 2013; 45:131-132. PMCID: PMC3984043.

Crago, AM, Chmielecki, J., Rosenberg, M., O’Connor, R., Byrne, C., Wilder, FG, Agius, P, Socci, ND, Qin, LX, Meyerson, M, Hameed, M, and Singer S. Near universal detection of alterations in CTNNB1 and Wnt pathway regulators in desmoid-type fibromatosis by whole-exome sequencing and genomic analysis. Genes, Chromosomes and Cancer, Oct 2015; 54:606-15.  PMCID:PMC26171757.

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Aimee Crago, MD, PhD

Aimee Crago, MD, PhD

  • Physician-scientist Aimee Crago studies mechanisms by which common genomic events drive initiation and progression of soft tissue tumors.
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Physician profile
Lab Affiliations


  • Award of Courage Fellow, Memorial Sloan Kettering Cancer Center, 2009
  • American Society of Clinical Oncology Young Investigator Award, 2010
  • American College of Surgeons Franklin Martin Faculty Research Fellowship, 2013
  • American Cancer Society Research Scholar, 2015

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Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Aimee Crago discloses the following relationships and financial interests:

  • Springworks Therapeutics
    Professional Services and Activities (Uncompensated)
  • Wolters Kluwer
    Professional Services and Activities

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