The rarity of soft tissue sarcomas has historically made the definition of genomic drivers of their initiation and progression difficult. Through copy number, whole exome and transcriptome analyses, however, common events associated with these lesions have recently been defined. The focus of our laboratory is to understand how these events, in the context of a mesenchymal cell background, promote sarcomagenesis. Using in vitro and in vivo techniques, we hope to use this information to identify novel predictive markers and therapeutic targets with potential to inform patient care.
Chmielecki J*, Crago AM*, Rosenberg M, O’Connor R, Walker SR, Ambrogio L, Auclair D, McKenna A, Heinrich MC, Frank DA, Meyerson M (*equal contribution). Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors. Nature Genetics Feb 2013; 45:131-132. PMCID: PMC3984043.
Crago, AM, Chmielecki, J., Rosenberg, M., O’Connor, R., Byrne, C., Wilder, FG, Agius, P, Socci, ND, Qin, LX, Meyerson, M, Hameed, M, and Singer S. Near universal detection of alterations in CTNNB1 and Wnt pathway regulators in desmoid-type fibromatosis by whole-exome sequencing and genomic analysis. Genes, Chromosomes and Cancer, Oct 2015; 54:606-15. PMCID:PMC26171757.