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Functional MRI for Brain Tumor Pre-Operative Planning

A major clinical application of functional MRI (fMRI) is pre-operative planning during the neurosurgical care of patients with brain tumors. While structural MRI allows for improved visualization of the tumor and surrounding brain regions, fMRI provides the additional advantage of identifying major functioning areas around the tumor so that neurosurgical intervention can avoid these eloquent areas and maximally resect the tumor. Our work explores the advantages and limitations of fMRI in the context of brain tumors.

  1. Ruff IM, Petrovich-Brennan NM, Peck KK, Hou BL, Tabar V, Brennan CW, Holodny AI. Assessment of the language laterality index in patients with brain tumor using functional MR imaging: effects of thresholding, task selection, and prior surgery. AJNR Am J Neuroradiol. 2008. 29(3):528-35.

  2. Peck KK, Bradbury M, Petrovich N, Hou BL, Ishill N, Brennan C, Tabar V, Holodny AI. Presurgical evaluation of language using functional magnetic resonance imaging in brain tumor patients with previous surgery. Neurosurgery. 2011. 64(4):644-52.

  3. Fraga de Abreu VH, Peck KK, Petrovich-Brennan NM, Woo KM, Holodny AI. Brain Tumors: The influence of tumor type and routine MR imaging characteristics at BOLD functional MR imaging in the primary motor gyrus. Radiology. 2016. 281(3):876-883.