Chrysothemis Brown: Publications

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Brown C, Rudensky A. (2021). Conceiving the inconceivable: the function of Aire in immune tolerance to peripheral tissue-restricted antigens in the thymus. J Immunol 206:245-247

Brown C, Wolchok J. (2020). PD-L1 Blockade Therapy: Location, Location, Location. Cancer Cell 38:615-617

Brown C, Rudensky A. (2020). Enforcing T cell innocence. Science 367:247-248

Penkava F, Velasco-Herrera M, Young M, Yager N, Nwosu L, Arthur Pratt, Alicia Lledo Lara, Charlotte Guzzo, Asher Maroof, Lira Mamanova, Suzanne Cole, Mirjana Efremova, Davide Simone, Andrew Filer, Brown C, Croxford A, Isaacs J Teichmann S, Bowness P, Behjati S, Al-Mossawi H. (2020). Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis Nature Communications 11:4767

Thangavelu G, Wang C, Loschi M, Saha A, Osborn M, Furlan S, Aoyama K, Mcdonald-Hyman C, Aguilar E, Janesick A, Chandraratna R, Refaeli Y, Macdonald K, Hill G, Zeiser R, Maillard I, Serody J, Murphy W, Munn D, Blumberg B, Brown C, Kuchroo V, Kean L, Hippen K, Noelle R, Blazar B (2020). Repurposing a novel anti-cancer RXR agonist to attenuate acute GVHD and maintain graft-versus-leukemia responses (in press 2020). Blood

Brown C*, Gudjonson H,*Pritykin Y, Deep D, Lavalle V, Mendoza A, Fromme R, Mazutis L, Ariyan C, Leslie C, Pe’er D, Rudensky, A. (2019). Transcriptional basis of dendritic cell heterogeneity in mouse and humans. Cell 179:846-863 *co-author co-corresponding author

Duurland C, Brown C, O’Shaughnessy R, Wedderburn L. (2017). CD161+ Tconv and CD161+ Treg Share a Transcriptional and Functional Phenotype despite Limited Overlap in TCRβ Repertoire. Front Immunol; 8: 103

Brown C,* Esterhazy, D, Sarde, A, London, M, Pullabhatla, V, Osma-Garcia, I, al-Bader, R, Ortiz, C, Elgueta, R, Arno, M, de Rinaldis, E, Mucida D, Lord G, Noelle, R. (2015). Retinoic acid is essential for Th1 cell lineage stability and prevents transition to a Th17 cell program. Immunity 42:499-511 *co-corresponding author

Brown C, Noelle R. (2015). Seeing through the dark: New insights into the immune regulatory functions of vitamin A. Eur J Immunol 45:1287–1295

Guo Y, Brown C, Ortiz C, Noelle R. (2015). Leukocyte Homing, Fate and Function are controlled by Retinoic Acid. Physiological Reviews 95: 125-148

Guo Y, Lee Y, Brown C, Zhang W, Usherwood E, Noelle R. (2014). Dissecting the Role of Retinoic Acid Receptor Isoforms in the CD8 Response to Infection. J Immunol 192:3336-3344

Brown C, Wedderburn L. (2014). Mapping autoimmune disease epigenetics: what’s on the horizon? Nat Rev Rheumatol 11:131-132

Brown C, Sebire N, Wittenhagen P, Shaw O, Marks S. (2014). Clinical significance of isolated v lesions in paediatric renal transplant biopsies: muscular arteries required to refute the diagnosis of acute rejection. Transplant International 27: 170–175

Brown C, Apps J, Winyard P. (2013). A new generation of academic paediatricians. The Lancet 382:28

Brown C, Apps J, Davies G, Ware N, Fisher J., Winyard P. (2013). Making your way as an academic paediatric trainee in the UK Archives of Disease in Childhood - Education and Practice.

Brown C, Haringman N, Davies C, Gore C, Hussain M, Mieli-Vergani G, Vergani D, Warner JO, Marks SD, Boyle RJ. (2012). High prevalence of food sensitisation in young children with liver disease: a clue to food allergy pathogenesis? Pediatr Allergy Immunol: 23: 770–777.

Pino-Lagos K, Guo Y, Brown C, Alexander M, Elgueta R, Bennett K, De Vries V, Nowak E, Blomhoff E, Sockanathan S, Chandraratna R, Dmitrovsky E, and Noelle R. (2011). A retinoic acid–dependent checkpoint in the development of CD4+ T cell–mediated immunity. J Exp Med; 208:1767-1775

  1. Chapters:

Brown C, (2017). Chapter: Vitamins, calcium, bone disorders, Clinical Pharmacology, Bennett, P., Brown M., & Sharma, P. (eds), 12th ed. Elsevier