Memorial Hospital Research Laboratories

The Constantinos Sofocleous Lab


Constantinos T. Sofocleous
Constantinos Sofocleous, MD, PhD

The Constantinos Sofocleous Lab focuses in the exploration, assessment, and validation of tissue and image biomarkers after local and locoregional therapies for metastatic colorectal cancer. The research staff includes experts in radiation physics, 3D software applications in medicine, histopathology and molecular cytology, immune response and cross-sectional and metabolic imaging. Ongoing collaborations with molecular cytology core lab, epidemiology and statistics, radiation safety and physics are crucial for the translational aspects of our research. Additional collaborators include clinical pathologists, computational laboratories, immunology experts bioengineers, interventional radiologists and medical oncologists.

Research Projects

Publications Highlights

Zirakchian Zadeh M, Yeh R, Kunin HS, Kirov AS, Petre EN, Gönen M, Silk M, Cornelis FH, Soares KC, Ziv E, Solomon SB, Sotirchos VS, Sofocleous CT. Real-Time Split-Dose PET/CT-Guided Ablation Improves Colorectal Liver Metastasis Detection and Ablation Zone Margin Assessments without the Need for Repeated Contrast Injection. Cancers. 2022; 14(24):6253.

Vasiniotis Kamarinos N, Gonen M, Sotirchos V, Kaye E, Petre EN, Solomon SB, Erinjeri JP, Ziv E, Kirov A, Sofocleous CT. 3D margin assessment predicts local tumor progression after ablation of colorectal cancer liver metastases. Int J Hyperthermia. 2022;39(1):880-887. doi: 10.1080/02656736.2022.2055795. PMCID: PMC9442248. 

Vasiniotis Kamarinos N, Vakiani E, Gonen M, Kemeny NE, Sigel C, Saltz LB, Brown KT, Covey AM, Erinjeri JP, Brody LA, Ziv E, Yarmohammadi H, Kunin H, Barlas A, Petre EN, Kingham PT, D’Angelica MI, Manova-Todorova K, Solomon SB, Sofocleous CT. Biopsy and Margins Optimize Outcomes after Thermal Ablation of Colorectal Liver Metastases. Cancers (Basel). 2022 Jan 29;14(3):693. doi: 10.3390/cancers14030693. PMID: 35158963.

Vasiniotis Kamarinos N, Vakiani E, Fujisawa S, Gonen M, Fan N, Romin Y, Do RKG, Ziv E, Erinjeri JP, Petre EN, Sotirchos VS, Camacho JC, Solomon SB, Manova-Todorova K, Sofocleous CT. Immunofluorescence Assay of Ablated Colorectal Liver Metastases: The Frozen Section of Image-Guided Tumor Ablation? J Vasc Interv Radiol. 2022 Mar;33(3):308-315.e1. doi: 10.1016/j.jvir.2021.11.008. Epub 2021 Nov 17. PMID: 34800623.

Kurilova I, Beets-Tan RGH, Flynn J, Gönen M, Ulaner G, Petre EN, Edward Boas F, Ziv E, Yarmohammadi H, Klompenhouwer EG, Cercek A, Kemeny NA, Sofocleous CT. Factors Affecting Oncologic Outcomes of 90Y Radioembolization of Heavily Pre-Treated Patients with Colon Cancer Liver Metastases. Clin Colorectal Cancer. 2019 Mar;18(1):8-18. doi: 10.1016/j.clcc.2018.08.004. Epub 2018 Sep 13. PMID: 30297264; PMCID: PMC6884072.

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Constantinos T. Sofocleous

Constantinos Sofocleous, MD, PhD

  • Interventional radiologist Constantinos Sofocleous leads research in the optimization of image-guided therapies for colorectal cancer metastases.
  • MD, PhD, University of Athens School of Medicine (Greece)
[email protected]
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Office Phone
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Timothy Cooke

Medical Student

Mohammad Elsayed

IR Fellow

Jon Heiselman

Research Scholar

Yulia Kitsel

Research Fellow

Henry Kunin

Clinical Research Associate

Amgad M. Moussa

Assistant Professor, Interventional Oncologist/Radiologist

Elena N. Petre

Senior Research Scientist

Vlasios S. Sotirchos

Assistant Professor, Interventional Oncologist/Radiologist

Randy Yeh

Assistant Professor, Radiologist

Mahdi Zirakchian Zadeh

Senior Research Scientist

Lab Affiliations


  • SIR 2023 Medical Student Scholar (Timothy Cooke)
  • Outstanding Clinical Study award, the highest honor the JVIR awards for individual papers, 2022
  • NIH/NCI R21 Award: Tissue Examinations from ablated Liver Tumors (2009)
  • NIH/NCI R01 Optimizing Thermal Ablation for Colon Cancer Liver Metastases
  • IMRAS/BSX/SIRTEX Grants Correlation of Histopathological findings with Radiation Exposure Levels after Y90 Radioembolization of Hepatic Metastases
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  • Ethicon Ablation Registry and Ablation assessment Grants
  • Society of Interventional Oncology Ablation with Confirmation of Colorectal Liver Metastases (ACCLAIM) Trial
  • General grant from the Society of Interventional Radiology (SIR) Foundation: Correlations of Tumor Absorbed Dose to Histopathologic Changes and Local Tumor Control

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

Research Fellow

Research position available in our Interventional Oncology Lab dedicated in the development and assessments of tissue and surrogate image biomarkers applied in image-guided therapies for metastatic colorectal disease.

Apply now

Get in Touch


Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Constantinos Sofocleous discloses the following relationships and financial interests:

  • Medtronic
    Professional Services and Activities
  • NeuWave Medical, Inc
    Professional Services and Activities
  • Terumo Medical Corporation
    Professional Services and Activities
  • Varian Medical Systems
    Professional Services and Activities

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2022 through disclosure submission in spring 2023). This data reflects interests that may or may not still exist. This data is updated annually.

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