Luke Pike: Publications

The Luke Pike Lab

Luke Pike: Publications


View a full listing of Luke Pike: Publications’ journal articles.

Saraf A, Pike LRG, Franck KH, Horick NK, Yeap BY, Fullerton BC, Wang IS, Abazeed ME, McKenna MJ, Mehan WA, Plotkin SR, Loeffler JS, Shih HA. Fractionated Proton Radiation Therapy and Hearing Preservation for Vestibular Schwannoma: Preliminary Analysis of a Prospective Phase 2 Clinical Trial. Neurosurgery. 2022 May 1;90(5):506-514. doi: 10.1227/neu.0000000000001869.

Mathis NJ, Wijetunga NA, Imber BS, Pike LRG, Yang JT. Recent Advances and Applications of Radiation Therapy for Brain Metastases. Curr Oncol Rep. 2022 Mar;24(3):335-342. doi: 10.1007/s11912-022-01209-z. Epub 2022 Feb 8. Review.

Qian JM, Akama-Garren E, Shin J, Gunasti L, Bang A, Pike LRG, Grassberger C, Schoenfeld JD. Dosimetric Modeling of Lymphopenia in Patients With Metastatic Cancer Receiving Palliative Radiation and PD-1 Immune Checkpoint Inhibitors. Adv Radiat Oncol. 2022 Mar-Apr;7(2):100880. doi: 10.1016/j.adro.2021.100880. eCollection 2022 Mar-Apr. PubMed Central PMCID: PMC8783121.

Yang DD, Mahal BA, Pike LRG. Biomarkers in Nonmetastatic Castrate-Resistant Prostate Cancer: A Step in the Right Direction. JAMA Oncol. 2021 Jul 1;7(7):1014-1015. doi: 10.1001/jamaoncol.2021.1358.

Pike LRG, Royce TJ, Mahal AR, Kim DW, Hwang WL, Mahal BA, Sanford NN. Outcomes of HPV-Associated Squamous Cell Carcinoma of the Head and Neck: Impact of Race and Socioeconomic Status. J Natl Compr Canc Netw. 2020 Feb;18(2):177-184. doi: 10.6004/jnccn.2019.7356. PubMed Central PMCID: PMC7384230.

Sanford NN, Hwang WL, Pike LRG, Lam AC, Royce TJ, Mahal BA. Trimodality therapy for HPV-positive oropharyngeal cancer: A population-based study: Trimodality therapy for HPV+ OPC. Oral Oncol. 2019 Nov;98:28-34. doi: 10.1016/j.oraloncology.2019.09.009. Epub 2019 Sep 16. PubMed Central PMCID: PMC7358785.

Mahal AR, Butler S, Franco I, Muralidhar V, Larios D, Pike LRG, Zhao SG, Sanford NN, Dess RT, Feng FY, D’Amico AV, Spratt DE, Yu JB, Nguyen PL, Rebbeck TR, Mahal BA. Conservative management of low-risk prostate cancer among young versus older men in the United States: Trends and outcomes from a novel national database. Cancer. 2019 Oct 1;125(19):3338-3346. doi: 10.1002/cncr.32332. Epub 2019 Jun 28.

Sanford NN, Mahal BA, Royce TJ, Pike LRG, Hwang WL. Sex Disparity and Copy Number Alterations in Esophageal Squamous Cell Carcinoma. Clin Gastroenterol Hepatol. 2019 May;17(6):1207-1209. doi: 10.1016/j.cgh.2018.08.026. Epub 2018 Aug 16.

Pike LRG, D’Amico AV. Author Reply. Urology. 2019 Apr;126:151. doi: 10.1016/j.urology.2018.11.058.

Pike LRG, Wu J, Chen MH, Loffredo M, Renshaw AA, Pfail J, Kantoff PW, D’Amico AV. Time to Prostate-specific Antigen Nadir and the Risk of Death From Prostate Cancer Following Radiation and Androgen Deprivation Therapy. Urology. 2019 Apr;126:145-151. doi: 10.1016/j.urology.2018.11.056. Epub 2019 Jan 18. PubMed Central PMCID: PMC7829036.

Fareed MM, Pike LRG, Bang A, Huynh MA, Taylor A, Spektor A, Awad MM, Ott PA, Krishnan M, Balboni TA, Schoenfeld JD. Palliative Radiation Therapy for Vertebral Metastases and Metastatic Cord Compression in Patients Treated With Anti-PD-1 Therapy. Front Oncol. 2019;9:199. doi: 10.3389/fonc.2019.00199. eCollection 2019. PubMed Central PMCID: PMC6450051.

Pike LRG, McKenna MJ, Shih HA. With Regard to the Brainstem, Size Matters Most. Int J Radiat Oncol Biol Phys. 2019 Mar 15;103(4):799-800. doi: 10.1016/j.ijrobp.2018.11.023.

Pike LRG, Bang A, Mahal BA, Taylor A, Krishnan M, Spektor A, Cagney DN, Aizer AA, Alexander BM, Rahma O, Balboni T, Ott PA, Hodi FS, Schoenfeld JD. The Impact of Radiation Therapy on Lymphocyte Count and Survival in Metastatic Cancer Patients Receiving PD-1 Immune Checkpoint Inhibitors. Int J Radiat Oncol Biol Phys. 2019 Jan 1;103(1):142-151. doi: 10.1016/j.ijrobp.2018.09.010. Epub 2018 Sep 15.

Pike LRG, Hwang WL, Royce TJ, Sanford NN, Mahal BA. HPV status predicts for improved survival following chemotherapy in metastatic squamous cell carcinoma of the oropharynx. Oral Oncol. 2018 Nov;86:69-74. doi: 10.1016/j.oraloncology.2018.09.007. Epub 2018 Sep 15.

Hwang WL, Pike LRG, Royce TJ, Mahal BA, Loeffler JS. Safety of combining radiotherapy with immune-checkpoint inhibition. Nat Rev Clin Oncol. 2018 Aug;15(8):477-494. doi: 10.1038/s41571-018-0046-7. Review.

Pike LRG, Bang A, Ott P, Balboni T, Taylor A, Catalano P, Rawal B, Spektor A, Krishnan M, Cagney D, Alexander B, Aizer AA, Buchbinder E, Awad M, Gandhi L, Hodi FS, Schoenfeld JD. Radiation and PD-1 inhibition: Favorable outcomes after brain-directed radiation. Radiother Oncol. 2017 Jul;124(1):98-103. doi: 10.1016/j.radonc.2017.06.006. Epub 2017 Jun 26.

Bang A, Wilhite TJ, Pike LRG, Cagney DN, Aizer AA, Taylor A, Spektor A, Krishnan M, Ott PA, Balboni TA, Hodi FS, Schoenfeld JD. Multicenter Evaluation of the Tolerability of Combined Treatment With PD-1 and CTLA-4 Immune Checkpoint Inhibitors and Palliative Radiation Therapy. Int J Radiat Oncol Biol Phys. 2017 Jun 1;98(2):344-351. doi: 10.1016/j.ijrobp.2017.02.003. Epub 2017 Feb 11.

Stachelek GC, Peterson-Roth E, Liu Y, Fernandez RJ 3rd, Pike LR, Qian JM, Abriola L, Hoyer D, Hungerford W, Merkel J, Glazer PM. YU238259 Is a Novel Inhibitor of Homology-Dependent DNA Repair That Exhibits Synthetic Lethality and Radiosensitization in Repair-Deficient Tumors. Mol Cancer Res. 2015 Oct;13(10):1389-97. doi: 10.1158/1541-7786.MCR-15-0036. Epub 2015 Jun 26. PubMed Central PMCID: PMC4618103.

Pike LR, Singleton DC, Buffa F, Abramczyk O, Phadwal K, Li JL, Simon AK, Murray JT, Harris AL. Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival. Biochem J. 2013 Jan 15;449(2):389-400. doi: 10.1042/BJ20120972.

Pike LR, Phadwal K, Simon AK, Harris AL. ATF4 orchestrates a program of BH3-only protein expression in severe hypoxia. Mol Biol Rep. 2012 Dec;39(12):10811-22. doi: 10.1007/s11033-012-1975-3. Epub 2012 Oct 23.

Phadwal K, Alegre-Abarrategui J, Watson AS, Pike L, Anbalagan S, Hammond EM, Wade-Martins R, McMichael A, Klenerman P, Simon AK. A novel method for autophagy detection in primary cells: impaired levels of macroautophagy in immunosenescent T cells. Autophagy. 2012 Apr;8(4):677-89. doi: 10.4161/auto.18935. Epub 2012 Apr 1. PubMed Central PMCID: PMC3405842.

Yang J, Jubb AM, Pike L, Buffa FM, Turley H, Baban D, Leek R, Gatter KC, Ragoussis J, Harris AL. The histone demethylase JMJD2B is regulated by estrogen receptor alpha and hypoxia, and is a key mediator of estrogen induced growth. Cancer Res. 2010 Aug 15;70(16):6456-66. doi: 10.1158/0008-5472.CAN-10-0413. Epub 2010 Aug 3. PubMed Central PMCID: PMC4261152.

Milani M, Rzymski T, Mellor HR, Pike L, Bottini A, Generali D, Harris AL. The role of ATF4 stabilization and autophagy in resistance of breast cancer cells treated with Bortezomib. Cancer Res. 2009 May 15;69(10):4415-23. doi: 10.1158/0008-5472.CAN-08-2839. Epub 2009 May 5.

Croke JM, Pike LR, MacPhee DJ. The focal adhesion protein Hic-5 is highly expressed in the rat myometrium during late pregnancy and labour and co-localizes with FAK. Reprod Biol Endocrinol. 2007 Jun 5;5:22. doi: 10.1186/1477-7827-5-22. PubMed Central PMCID: PMC1892559.