Human Oncology & Pathogenesis Program
The Sarat Chandarlapaty Lab
Research
The goal of our research program is to understand the detailed mechanisms by which a cancer cell can develop resistance to therapies targeting its oncogenic driver; and to exploit those findings to elucidate the biology of cancer and identify more effective treatments for cancer patients. The focus of this work has been on signaling networks emanating from the hormone receptor, ERa, and the receptor tyrosine kinase, HER2. These two signals play a dominant role in cancers of the breast, with roughly 85% of all tumors driven by one or both of these receptors. Whereas drugs targeting these signals have major benefits in patients, resistance to therapy is frequently encountered. Our studies have centered on (1) understanding how cancers evolve to resist therapies against ER, CDK4/6, HER2, and PI3K and (2) development of mechanism-based drugs or treatment strategies that can prevent or overcome these modes of resistance.
People
Sarat Chandarlapaty, MD, PhD
Naddisy Foundation Chair in Breast Cancer Research
- Physician-scientist Sarat Chandarlapaty studies the regulation of growth factor signaling networks in cancer.
- PhD, University of North Carolina
- [email protected]
- Email Address
- View physician profile
- Physician profile
Members
Senior Research Scientist
WGS Student
Assistant Attending
Research Scholar
Assistant Attending
GSK Graduate Student
Research Scholar
Graduate Student
Research Lab Manager
Research Technician
Lab Alumni
Research Technician
Research Technician
Graduate Student
Graduate Student
Project Owner, Larvol
Research Technician
Visiting Investigator
Research Fellow
Research Fellow
Research Fellow
Research Associate
Research Associate
Research Technician
Research Secretary
Research Technician Sr.
Graduate Student
Research Fellow
Research Fellow
Research Technician
Assistant Attending
Graduate Research Assistant
Lab Affiliations
Achievements
- Professor of Medicine, Weill Cornell Medical College and Weill Cornell Cell and Developmental Biology Program
- Member Memorial Sloan Kettering Cancer Center, Department of Medicine and Human Oncology and Pathogenesis Program