News from the Tow Center for Developmental Oncology

News from the Tow Center for Developmental Oncology

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Finding
Genetic counselor Elise Fiala and pediatric cancer expert Michael Walsh
Study Demonstrates the Reasons to Screen Children with Cancer for Inherited Cancer Genes
The largest study of its kind to look at data from children with cancer finds inherited cancer genes are more common than expected.
Medical oncologist Nai-Kong Cheung.
Novel Treatment Pioneered by MSK Kids Researchers Receives FDA Approval for Patients with High-Risk Neuroblastoma
The US Food and Drug Administration (FDA) has approved the drug naxitamab (Danyelza) for the treatment of patients with high-risk neuroblastoma. The drug, also known as humanized 3F8, was developed by researchers at MSK Kids, the pediatric cancer program at Memorial Sloan Kettering.
Finding
Researchers Ahmet Zehir and Elli Papaemmanuil talk while looking at a computer.
Why Do Certain Chemotherapies Increase the Likelihood of Blood Cancer?
New research focuses on clonal hematopoiesis, an age-related blood condition that increases the risk of blood cancer.
In the Lab
Cancer biologist and pediatric oncologist Alex Kentsis
Analyzing Urine Can Guide the Treatment of Childhood Kidney Tumors
A protein detected in the urine of children with Wilms’ tumor led to the development of a test to improve diagnosis and treatment.
In the Lab
Mutlinucleated muscle cells from flies
Scientists Home In On “Equation” for Muscle Cell Size
A new study in flies reveals a previously unknown type of cooperation at work in muscle cells.
In the Lab
In this fluorescent microscopy image of endoderm tissue from a mouse embryo, cell membranes are red, cell nuclei are blue, and extra-embryonic endoderm cells are green (they appear turquoise because blue and green are merged).
Scientists Rewrite the Textbook of Organ Development, One Cell at a Time
A large study that analyzed nearly 120,000 cells in a developing mouse embryo is full of surprises.
Feature
Pediatric oncologists Andrew Kung, Neal Shukla, and Fil Dela Cruz
One by One: How MSK Kids Is Using Precision Medicine to Tailor Treatment for Children with Cancer
Learn how the Pediatric Translational Medicine Program at Memorial Sloan Kettering is bringing together experts to make new discoveries about pediatric cancer.
Finding
Alex Kentsis in his lab
Research Uncovers the Genetic Causes of Aggressive Leukemia in Children
Researchers have found that the genetic changes that cause pediatric leukemia are different from those that lead to leukemia in adults.
In the Lab
MSK physician-scientist Omar Abdel-Wahab
Splicing May Be an Effective Target in the Fight against Cancer
New drugs are being developed that target part of the process to make proteins.
Science Byte
Cancer biologist and pediatric oncologist Alex Kentsis
Blocking Enzymes That Signal DNA Damage Could Be a Treatment Strategy for Childhood Cancers
A new strategy for treating pediatric cancers involves preventing cells from repairing their own DNA.
Science Byte
Developmental biologist Anna-Katerina (Kat) Hadjantonakis
It Takes Two: A Pair of Proteins Coordinate to Direct Development of Embryonic Cells
MSK researchers shed light on the signals that determine the fate of embryonic cells.
In the Clinic
MSK pediatric oncologist and neuroblastoma expert Kim Kramer
FDA Grants Breakthrough Therapy Designation to Omburtamab for Metastatic Neuroblastoma
A drug created at MSK called burtomab reaches an important milestone toward becoming a treatment for metastatic neuroblastoma.
In the Lab
Cancer biologist and pediatric oncologist Alex Kentsis
Jumping Genes and the Dark Genome: MSK Researchers Gain New Insight into Childhood Cancers
Researchers have discovered a genetic mechanism that may trigger most childhood cancers.
Finding
MSK geneticist and pediatric oncologist Michael Walsh
Childhood Cancer Survivors Found to Have Inherited Mutations Increasing Risk of the Disease
MSK geneticist and pediatric oncologist Michael Walsh discusses new findings on inherited mutations in pediatric cancer survivors.
In the Lab
Pictured: Nai-Kong Cheung
Researchers Find Gene Mutations Linked to Age at Neuroblastoma Diagnosis
In a large-scale genome-sequencing study, researchers discovered mutations in neuroblastoma tumors that could aid the development of diagnostic tests and therapies.