Search

Molecular biologist Simon Powell investigates DNA replication and recombination, chromosome dynamics, and human genetics.

… The major theme of our work is how DNA repair processes are disrupted in human cancers and how this can be exploited therapeutically.   Join the Powell Lab! Simon N. Powell, MD, PhD Enid A. Haupt Chair in Radiation Oncology Professor PhD, MD, University of London Email [email protected] Laboratory phone

Physician-scientist Karlo Perica develops cell therapies to treat a wide variety of cancers, focusing on off-the-shelf approaches such as allogeneic CAR T cells and in vivo gene editing.

… The laboratory of Dr. Karlo Perica focuses on developing new Chimeric Antigen Receptor T cell and other cell therapies for cancer. We seek to make cell therapy more accessible and more effective by developing “off-the-shelf” approaches using allogeneic cell therapies and in vivo editing. Our research

Jonathan Coleman is a physician-scientist focused on translational research, cancer genomics, and patient-derived organoid models in the study of urologic malignancies. Ongoing work includes the development of local ablative therapies, their influence on the tumor microenvironment, and implications for therapy response.

… Our lab is focused on understanding the mechanism of disease recurrence, response to therapies and disease progression of upper tract urothelial cancer, a rare but aggressive disease. To interrogate molecular diversity of the disease, we employ genomics, transcriptomics, metabolomics and tumor immune

Xinbo Yang’s lab applies structural biology and protein engineering to decode T cell receptor specificity in cancer and autoimmune disease.

… The Xinbo Yang lab is interested in studying the T cell receptor (TCR) specificity in cancer and autoimmune disease. The patrolling T cells constantly scan host tissues to eliminate infected or malignant cells. Failure to recognize such cells leads to pathogen evasion or cancer. Whereas mis-recognizing

The Antonsecu lab focuses on translocation-associated sarcoma pathogenesis and generating in vitro models.

… An on-going focus of our work is the genomic investigation of pediatric and young adult unclassified mesenchymal tumors, with a special emphasis on detecting novel gene fusions drivers. By applying highly efficient RNAseq and FusionSeq pipelines for novel translocation discovery in tumors that lack known

Developmental biologist Luis F. Parada uses genetically engineered mouse models to study neurofibromatosis, brain tumors, cancer stem cells, and tumor progression.

… The Parada lab uses genetically engineered mouse models to recapitulate and study human disease. These mouse strains are used to understand the natural history of tumors of the nervous system, including glioblastoma multiforme (GBM), malignant peripheral nerve sheath tumors (MPNST), neurofibromas, and

New roles for Notch signaling in the immune system.

… Dr. Maillard’s research focuses on the role of Notch signaling in hematopoiesis as well as in T and B cell development, differentiation and function. Through more than 15 years of research in the field, his laboratory discovered essential functions for Notch receptors and ligands in graft-versus-host

The Huangfu laboratory uses human pluripotent stem cells (hPSCs) as a powerful genetic model to interrogate the transcriptional and epigenetic mechanisms underlying cell fate decisions in development and disease.

… We apply both precision gene editing and large-scale CRISPR screening in human pluripotent stem cells (hPSCs) to explore mechanisms underlying human development. Specifically, we are interrogating the protein-coding regulators of pancreatic development and β cell function. The pathways that regulate

Radiologist and Nuclear Medicine physician Jan Grimm develops novel approaches for improved diagnosis, monitoring and therapy of prostate and other cancers.

… The Grimm lab in the Molecular Pharmacology Program focuses on the development of novel and innovative approaches for cancer diagnostics and therapy. These approaches evaluate underlying biology and utilize nanotechnology, chemistry and physics interrogated with modern imaging methods. The lab focuses

Cancer biologist Tuomas Tammela investigates cellular heterogeneity in lung and pancreatic cancers.

… The Tammela lab is interested in understanding the remarkable phenotypic heterogeneity of cancer cells within tumors. We approach this question using a combination of sophisticated genetically engineered mouse models, single-cell approaches, tracing and ablation of distinct tumor cell lineages, CRISPR-mediated