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Physician-scientist Adam Schmitt studies how long noncoding RNAs regulate cellular stress responses and tumor development.

… Until recently, the vast majority of the noncoding genome was thought be nonfunctional. Thanks to the rapid development of functional genomics, we now know that the noncoding genome is packed with a diverse array of noncoding RNAs and gene regulatory elements. Indeed, it is estimated that more than 80

Cell biologist Philipp Niethammer investigates tissue damage responses with advanced imaging approaches in zebrafish.

… Interdisciplinary approaches to wound healing, inflammation and regeneration. Philipp Niethammer, PhD Professor PhD, European Molecular Biology Laboratories & Hamburg University, Germany Achievements Dorsett L. Spurgeon Distinguished Research Award (2009) Louis Gerstner Young Investigator (2012) American

Lydia Finley studies the mechanisms that link metabolic pathways to cell fate decisions.

… The Finley Lab investigates how cellular metabolic pathways regulate cell fate decisions in stem cells and cancer cells. We combine genetic and metabolomic approaches to investigate cell-type specific growth requirements and elucidate how flux through central metabolic pathways regulates key cellular

Computational chemist John Chodera uses statistical mechanics, molecular modeling, and automated biophysical experiments to help identify new potential therapeutics and investigate mechanisms of drug resistance in cancer.

… The Chodera lab uses computation and experiments to develop quantitative, multiscale models of the effects of small molecules on biomolecular macromolecules and cellular pathways. To do this, the group utilizes physical models and rigorous statistical mechanics, with the overall goals of engineering

Physician-scientist Richard Kolesnick studies the role of ceramide signaling in radiation-induced vascular dysfunction and tumor regression.

… Our laboratory focuses on the role of sphingolipid signaling as a stress response. In this pathway, generation of the second messenger ceramide in response to diverse environmental and pharmacologic stresses (heat, ionizing radiation, ultraviolet light, chemotherapeutic agents, oxidative challenges,

Immunology Program Chair Alexander Rudensky focuses on immunological tolerance and the differentiation and function of T cells.

… Our research is focused on understanding the molecular mechanisms governing the differentiation and function of CD4 T lymphocytes and their role in immunity and tolerance.  Major areas of interest include: the molecular and cellular mechanisms governing the differentiation and function of regulatory

The Sheu-Gruttadauria Lab investigates how biomolecular condensates and biological phase transitions shape gene expression in physiology and disease.

… The Sheu-Gruttadauria Lab asks fundamental questions about how the cell organizes gene expression. We are particularly interested in biomolecular condensates, a class of membraneless cellular compartments that concentrate factors involved in nearly every step of RNA metabolism from transcription to decay

The Ricardo Otazo lab develops novel magnetic resonance imaging (MRI) techniques for cancer applications including fast imaging, motion tolerant imaging, quantitative imaging of physical tissue parameters, and real-time MRI-guided radiotherapy using advances in MRI acquisition and computational models.

… The Ricardo Otazo lab develops novel magnetic resonance imaging (MRI) techniques for cancer applications including fast imaging, motion resistant imaging, quantitative imaging of physical tissue parameters, and real-time MRI-guided radiotherapy using advances in MRI acquisition and computational models

Dr. Jian Carrot-Zhang, PhD, is an Assistant Member in the Computational Oncology Service at MSK. Her research focuses on elucidating germline–somatic interactions across multi-ancestral populations.

… Dr. Jian Carrot-Zhang, PhD, is an Assistant Member in the Computational Oncology Service at MSK. Her research focuses on elucidating germline–somatic interactions across multi-ancestral populations. She develops computational and statistical approaches to characterize germline determinants of cancer

The goal of my research is to understand the mechanisms and structures of enzymes that perform and regulate essential nucleic acid transactions.

… The goal of my research is to understand the mechanisms and structures of enzymes that perform and regulate essential nucleic acid transactions. My research integrates diverse experimental approaches (including virology, biochemistry, structural biology, and genetics) and applies them to model systems