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The Pertsinidis laboratory uses single-molecule approaches to understand gene transcription and the function of complex macromolecular machines inside live cells.

… Our mission is the development of a “new” generation of optical imaging technologies to enable advances in two hitherto difficult-to-investigate areas: the real-time analysis of macromolecular interactions and motions at the nanometer scale in vivo and the three-dimensional architecture of complex molecular

Our group, the Laboratory of Experimental Cancer Immunogenomics, is a multi-disciplinary team of cancer scientists working at the intersection of genomics, molecular genetics, animal modeling, and biostatistical data sciences.

… Our group, the Laboratory of Experimental Cancer Immunogenomics, is a multi-disciplinary team of cancer scientists working at the intersection of  genomics ,  molecular genetics ,  animal modeling, and biostatistical data sciences . We are a mix of experienced researchers, postdoctoral fellows, clinical

The Wilkinson laboratory studies reverse transcriptases and retrotransposons using biochemistry, structural biology, and genome mining.

… Genetic information typically flows in one direction: from DNA to RNA to protein. Our lab is fascinated by reverse transcription, where this flow is flipped on its head, allowing RNA to be rewritten back into DNA. Reverse transcriptases are famously used by retroviruses like HIV to invade genomes, but

Human Oncology and Pathogenesis Program Chair Charles Sawyers develops molecularly targeted cancer therapy.

… Dr. Sawyers is an HHMI Investigator searching for molecularly targeted approaches to treat cancer. He has identified cell signaling components critical to the growth of cancer cells in chronic myeloid leukemia, prostate and other cancers, resulting in the development of multiple FDA-approved inhibitors

The Pavletich laboratory studies the structural biology of pathways that control cell growth and maintain the integrity of the genome.

… Our research group is interested in understanding, at the structural and mechanistic levels, the maintenance of genomic integrity and the control of cell growth, both of which figure prominently in cancer. In the area of growth control, our recent work is focused on the mTOR pathway that controls multiple

Derek Tan’s lab studies diversity-oriented synthesis and rational drug design of probes and lead compounds for chemical biology and drug discovery.

… The identification of small-molecule probes and therapeutic lead compounds to address novel biological targets is a significant current challenge in chemical biology and drug discovery. We are engaged in a two-pronged approach to this problem involving diversity-oriented synthesis and rational design

The Vardhana Lab studies how nutrient availability, uptake and metabolism regulates host immune responses during cancer development and immunotherapy.

… The Vardhana lab explores how metabolites regulate immune cell homeostasis, particularly within tumors.  We use a combination of traditional immunology, synthetic biology, metabolomics, and bioinformatics to answer fundamental biological questions about the regulation of immune responses with the goal

Molecular biologist John Maciejowski studies the causes of complex chromosome rearrangements and the patterns of hypermutation that shape cancer genomes.

… The nuclear envelope is a regulated membrane barrier that separates the nucleus from the cytosol in eukaryotes. Although the NE is often depicted as a static barrier, new research has identified conditions where nuclear envelope rupturing causes a loss of compartmentalization. Nuclear envelope ruptures

Alban Ordureau explores molecular signaling pathways that regulate cellular homeostasis, with a focus on the ubiquitin and autophagy systems.

… My group focuses on understanding cell signaling pathways primarily linked with the ubiquitin and autophagy systems and frequently altered in diseases, including neurodegenerative disease. To this end, we combine cell biological, genome engineering (CRISPR), and biochemical approaches to provide new

The Minn Lab investigates how cancers evolve under chronic inflammation and persistent immune pressure to acquire resistance to immunotherapies, with the goal of developing innovative therapies to restore anti-tumor immunity.

… In the Minn Lab, we interrogate the intersection of chronic inflammation and interferon signalling, virus mimicry pathways, and immune checkpoint resistance in tumor cells — integrating cellular, molecular and translational approaches. Our goal is to convert mechanistic insights into new therapeutic