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My laboratory and clinical research focus on understanding genomics and signaling in colorectal cancer to develop new treatments for patients.

… My laboratory and clinical research focus on understanding genomics and signaling in colorectal cancer to develop new treatments for patients. Colorectal tumors are characterized by a high level of baseline receptor tyrosine kinase (RTK) signaling. Oncogenic inhibition of these tumors, for example with

Dr. Yueming Li studies disease mechanism of Cancer and Alzheimer’s, with the goal of developing novel therapeutics for clinical use.

… Research Interests Basic & Translational research in Cancer and Alzheimer’s disease: From disease mechanism to therapeutic development. Research Areas Target Identification & Drug Discovery Chemical Biology & Medicinal Chemistry Biochemistry & Enzymology Biophysics & Structural Biology Animal models

Physician-scientist Adam Schmitt studies how long noncoding RNAs regulate cellular stress responses and tumor development.

… Until recently, the vast majority of the noncoding genome was thought be nonfunctional. Thanks to the rapid development of functional genomics, we now know that the noncoding genome is packed with a diverse array of noncoding RNAs and gene regulatory elements. Indeed, it is estimated that more than 80

Craig Thompson studies molecular signaling pathways that regulate nutrient uptake and the role these pathways play in the regulation of cell growth and survival.

… The Thompson laboratory has proposed that the basis of metazoan cell survival is determined by the inability of cells to take up nutrients in a cell-autonomous fashion. This hypothesis was formulated to explain how multicellularity might have arisen during evolution. We believe the lack of a cell-intrinsic

Cell biologist Meng-Fu Bryan Tsou studies cell cycle control of centrosome duplication and degeneration, as well as cilia assembly and disassembly.

… The goal of my research is to understand the biogenesis of centrioles/centrosomes and primary cilia, and how defects in these processes affect mammalian cell physiology and evoke stress responses. Using quantitative proteomics, super-resolution microscopy, comparative genomics, proximity labeling, and

The Lee laboratory studies the mechanisms governing homeostatic turnover and reparative programs in stem cells, with a focus on elucidating how tissue perturbations lead to lung disease.

… The Lee laboratory studies the mechanisms governing homeostatic turnover and reparative programs in stem cells, with a focus on elucidating how tissue perturbations lead to lung disease. Projects:  Elucidate the behaviors of stem cells and their niches during lung development, regeneration and disease

Physician-scientist Omar Abdel-Wahab studies the functional genomics of hematopoietic malignancies.

… Omar Abdel-Wahab is the Chair of SKI Molecular Pharmacology Program and an Attending Physician on the Leukemia Service in the Department of Medicine at Memorial Sloan Kettering Cancer Center. Omar Abdel-Wahab, MD Chair, Molecular Pharmacology Program, SKI; Evnin Family Chair in Molecular Pharmacology

Cell biologist Michael Overholtzer studies the mechanisms of tumor initiation and progression, cell adhesion, and cell death.

… The Overholtzer lab studies mechanisms of nutrient sensing and cellular responses to nutrient starvation, including the nutrient recycling pathway autophagy, scavenging pathways such as macropinocytosis, and mechanisms of cell death. We investigate cell death mechanisms that have unique effects on cell

Physician-scientist Karuna Ganesh studies stem cell plasticity in metastasis, therapy resistance and tissue regeneration.

… Metastasis causes >90% of cancer death.  The emergence, persistence, therapy resistance and lethality of metastatic cancer is driven by dynamic and tenacious metastasis stem cells (MetScs). The Ganesh lab focuses on understanding the molecular mechanisms that underlie the emergence of regenerative plasticity

The Diehl lab studies how the microbiota and other exogenous factors regulate development and function of the intestinal immune system.

… The intestinal immune system faces a number of unique challenges due to continuous exposure to rapidly changing exogenous factors including diet and intestinal microbes. Proper calibration of responses is needed to clear invading pathogens as well as repair damage. Over enthusiastic responses within