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Dr. Yueming Li studies disease mechanism of Cancer and Alzheimer’s, with the goal of developing novel therapeutics for clinical use.

… Research Interests Basic & Translational research in Cancer and Alzheimer’s disease: From disease mechanism to therapeutic development. Research Areas Target Identification & Drug Discovery Chemical Biology & Medicinal Chemistry Biochemistry & Enzymology Biophysics & Structural Biology Animal models

Molecular biologist Scott Keeney investigates mechanisms of the initiation of meiotic recombination.

… The long-range objectives of our research are to understand the mechanism of meiotic recombination and to determine how this process is coordinated with other events of meiotic prophase. Several projects in the lab focus on Spo11 (the protein that makes the DNA double-strand breaks (DSBs) that initiate

Cancer biologist Michael Kharas studies RNA regulators of self-renewal in both normal and leukemic hematopoiesis.

… The Kharas lab is working to identify critical pathways in both normal and leukemic hematopoietic cells. Michael G. Kharas, PhD Professor PhD, University of California Irvine Achievements Leukemia and Lymphoma Society Career Development Award (2017) Alex Lemonade Stand Foundation ‘A’ Award (2016) American

Physician-scientist Nai-Kong Cheung focuses on engineering antibodies and immune cells to treat both solid tumors and liquid tumors in children.

… My lab focuses on engineering antibodies and immune cells to treat both solid tumors and liquid tumors in children. Nai-Kong V. Cheung, MD, PhD Enid A. Haupt Chair in Pediatric Oncology, Pediatrics Professor MD, PhD (Immunology), Harvard Medical School Email [email protected] Laboratory phone 646-888

The Sfeir Lab investigates pathways that ensure genome fidelity and plasticity.

… Chromosomes are the fundamental structural units of our genome. The Sfeir lab seeks to understand basic chromosome biology and how their mismanagement manifests in disease. Our research is focused on three major areas: telomere maintenance, nuclear DNA repair, and mitochondrial DNA replication and repair

Physician-scientist Christopher A. Klebanoff studies T cell immunobiology with an emphasis on adoptive T cell immunotherapy for the treatment of solid malignancies.

… A form of cancer immunotherapy termed adoptive T cell transfer (ACT), in which a patient’s own T cells are engineered to recognize and attack cancer cells, can induce durable complete remissions in patients with advanced hematologic malignancies. By contrast, a similar approach has thus far failed to

Cell biologist Xuejun Jiang studies programmed cell death, molecular mechanisms, and their roles in tumorigenesis.

… The research of my laboratory focuses on two directions highly relevant to cancer biology, (1) the molecular basis of programmed cell death processes (including apoptosis and ferroptosis), and their roles in human disease; and (2) the molecular basis of autophagy and its role in cancer. We also study

Physician-scientist Rachel Niec studies how cells and tissues communicate to promote health or drive inflammation and cancer.

… Complex tissue functions, such as nutrient absorption and barrier defense in the intestine, are influenced and tuned by environmental cues and stresses. However, the environmentally tuned cellular interaction networks that define tissue health and resilience or predispose to disease states are poorly

… The Kung Lab leverages patient-driven discovery to identify drivers and therapeutic vulnerabilities in pediatric and young adult cancers. The research infrastructure of the lab bridges the clinic, dry lab, and wet lab, with experimental data derived from model systems as well as in-human studies. We

The Ricardo Otazo lab develops novel magnetic resonance imaging (MRI) techniques for cancer applications including fast imaging, motion tolerant imaging, quantitative imaging of physical tissue parameters, and real-time MRI-guided radiotherapy using advances in MRI acquisition and computational models.

… The Ricardo Otazo lab develops novel magnetic resonance imaging (MRI) techniques for cancer applications including fast imaging, motion resistant imaging, quantitative imaging of physical tissue parameters, and real-time MRI-guided radiotherapy using advances in MRI acquisition and computational models