Search

The Sfeir Lab investigates pathways that ensure genome fidelity and plasticity.

… Chromosomes are the fundamental structural units of our genome. The Sfeir lab seeks to understand basic chromosome biology and how their mismanagement manifests in disease. Our research is focused on three major areas: telomere maintenance, nuclear DNA repair, and mitochondrial DNA replication and repair

Cell biologist Xuejun Jiang studies programmed cell death, molecular mechanisms, and their roles in tumorigenesis.

… The research of my laboratory focuses on two directions highly relevant to cancer biology, (1) the molecular basis of programmed cell death processes (including apoptosis and ferroptosis), and their roles in human disease; and (2) the molecular basis of autophagy and its role in cancer. We also study

The Romesser lab studies colorectal and anal cancer with a focus on using radiotherapy to treat disease.

… Research of the Paul Romesser Laboratory focuses on three main concepts. First is the characterization of the processes of senescence. This includes senescence-associated secretory phenotype (SASP) induction and tumor microenvironment (TME) remodeling in response to radiation. Similarly, we seek to investigate

Immunologist Morgan Huse studies the structure and function of immune cell-cell interactions.

… In the Huse lab, we combine imaging technology with synthetic chemistry and materials science to understand how immune cells communicate. Morgan Huse, PhD Deputy Director for Core Technologies; Member, Immunology Program Professor PhD, The Rockefeller University Achievements Searle Scholar Award (2008

The Reznik Lab studies metabolic and mitochondrial dysfunction in cancer through analysis of multimodal genetic, metabolomic, and clinical data.

… The Reznik Lab studies metabolic and mitochondrial dysfunction in cancer through analysis of multimodal genetic, metabolomic, and clinical data. We use computational tools to address a basic question: how do tumors adapt their metabolism, the process by which they obtain energy and nutrition from the

Yael David’s lab develops and applies methods in chemical biology toward studying epigenetic regulation and its correlation with disease states.

… Research efforts in the David lab apply core techniques in chemical biology, biochemistry, and cell biology to address fundamental questions in the epigenetic regulation of transcription. Epigenetic regulation relies on the dynamic modification of the two building blocks of chromatin: DNA and histone

Physician-scientist Emily Cheng studies the molecular mechanisms of cell death and their implications in tumorigenesis, tumor-microenvironment interactions, targeted therapy, and immunotherapy.

… The focus of the Cheng laboratory is to elucidate the molecular mechanisms of cell death with an overarching goal of directly translating cell death mechanisms into novel anti-cancer therapeutic strategies that can effectively trigger cancer cell death and enhance anti-cancer immunity. Emily H. Cheng

Our team is focused on developing novel tools and approaches for the diagnosis and treatment of cancer using genomics as a guide.

… Our team is focused on developing novel tools and approaches for the diagnosis and treatment of cancer using genomics as a guide. Luis Diaz Jr., MD Head of the Division of Solid Tumor Oncology; Grayer Family Chair MD, University of Michigan Email [email protected] Office phone 646-888-4641

Physician-scientist Liang Deng studies poxvirus interface with the immune system and the development of poxviruses as oncolytic and immunotherapy for cancers.

… Our laboratory is focused on understanding how poxviruses are detected by the host innate immune sensing mechanisms and how poxviruses evade host antiviral responses. We are also interested in the development of poxvirus-based oncolytic and immunotherapy for cancers including melanoma. Liang Deng, MD

Chemical biologist Daniel Bachovchin designs selective inhibitors to study enzymes and pathways in cancer and immune system signaling.

… The Bachovchin lab uses chemical and cell biology approaches to study important questions in innate immunity. We are particularly interested in characterizing the molecular mechanisms controlling the formation of inflammasomes, key components of the innate immune system that sense intracellular danger