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The Baylies laboratory studies the mechanisms that form and maintain muscle both during normal development and in disease.

… Developmental biologist Mary Baylies studies the mechanisms that form and maintain muscle both during normal development and in disease.   Mary Baylies, PhD Professor PhD, The Rockefeller University Achievements Identified that global, regional, and local inputs contribute to nuclear size regulation

Cancer biologist Tuomas Tammela investigates cellular heterogeneity in lung and pancreatic cancers.

… The Tammela lab is interested in understanding the remarkable phenotypic heterogeneity of cancer cells within tumors. We approach this question using a combination of sophisticated genetically engineered mouse models, single-cell approaches, tracing and ablation of distinct tumor cell lineages, CRISPR-mediated

Biochemist and Bioengineer Kayvan Keshari explores changes in cancer metabolism to develop advanced imaging techniques and cancer therapeutics.

… The goal of our research program is to improve our biochemical understanding of cancer metabolism and use metabolic changes to develop non-invasive methods for diagnosis as well as approaches to treat cancer. Our work takes advantage of multi-modality methods at all scales, with a special focus in hyperpolarized

Physician-Scientist A. Ari Hakimi, MD studies genetic and metabolic mechanisms of immune response in kidney cancers.

… The Hakimi Lab aims to understand immune infiltration, inflammation, and the tumor microenvironment in RCC to identify novel therapeutic targets to overcome resistance to systemic therapies. These studies apply bulk, single-cell and spatial RNA sequencing, flow cytometry, and immunogenomic analyses to

Biomedical engineer Daniel Heller is Head of the Cancer Nanotechnology Laboratory, which invents disruptive technologies to revolutionize the diagnosis and treatment of cancer and allied diseases.

… Cancer Nanomedicine Laboratory We are a biomedical engineering laboratory that develops nanotechnologies to advance breakthroughs in the research, diagnosis, and treatment of cancer and allied diseases. We develop drug delivery technologies to target therapies to disease sites, advanced diagnostics to

Arvin Dar’s lab develops chemical tools and probes to explore disease mechanisms and the structural biology of cancer targets.

… The Dar laboratory explores cancer mechanisms and new approaches in chemical biology. Our research integrates genetics, biochemistry, structure, and small molecule discovery. Our primary goal is to develop tools that enable us to modulate cell signaling networks, allowing for in-depth mechanistic exploration

Molecular Pharmacology Program Member David Scheinberg focuses on the discovery and development of novel, specific immunotherapeutic agents and targeted nanodevices for cancer therapy.

… The overall goals of this laboratory are to develop novel targeted immunotherapies based on effectors of the immune system and to understand their mechanisms of action as well as the mechanisms of resistance to them. This includes antibodies, targeted nano-devices, engineered cells, and active specific

The Shah lab focuses on the major topics of cancer evolution, single cell genomics and transcriptomics, mutational processes and prediction of drug response.

… The Shah lab focuses on the major topics of cancer evolution, single cell genomics and transcriptomics, mutational processes and prediction of drug response. We are interested in the major questions which underpin the cellular dynamics of cancer. Why do some cancer patients respond to treatment, while

Systems biologist Thomas Norman develops new computational and functional genomics approaches for studying how genes interact to realize complex phenotypes.

… The Norman Lab aims to combine large-scale functional genomics experiments with computational modeling to enable rational engineering of cell state. Our primary model system is the fibroblast, a ubiquitous and phenotypically plastic cell type that plays a role in diverse pathologies. We played a foundational

Molecular and cell biologist Christine Mayr studies how 3′UTRs regulate protein functions and how mRNAs contribute to cytoplasmic organization.

… My laboratory studies the regulatory and structural roles of mRNAs in the cytoplasm. My laboratory studies the regulatory and structural roles of mRNAs in the cytoplasm. Specifically, we investigate how 3′UTRs regulate protein functions in a manner that is independent of protein abundance. We found that