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The Lee laboratory studies the mechanisms governing homeostatic turnover and reparative programs in stem cells, with a focus on elucidating how tissue perturbations lead to lung disease.

… The Lee laboratory studies the mechanisms governing homeostatic turnover and reparative programs in stem cells, with a focus on elucidating how tissue perturbations lead to lung disease. Projects:  Elucidate the behaviors of stem cells and their niches during lung development, regeneration and disease

Cell biologist Philipp Niethammer investigates tissue damage responses with advanced imaging approaches in zebrafish.

… Interdisciplinary approaches to wound healing, inflammation and regeneration. Philipp Niethammer, PhD Professor PhD, European Molecular Biology Laboratories & Hamburg University, Germany Achievements Dorsett L. Spurgeon Distinguished Research Award (2009) Louis Gerstner Young Investigator (2012) American

The Sheu-Gruttadauria Lab investigates how biomolecular condensates and biological phase transitions shape gene expression in physiology and disease.

… The Sheu-Gruttadauria Lab asks fundamental questions about how the cell organizes gene expression. We are particularly interested in biomolecular condensates, a class of membraneless cellular compartments that concentrate factors involved in nearly every step of RNA metabolism from transcription to decay

The Gitlin Lab studies the molecular and cellular mechanisms underlying inflammatory cell signaling in health and disease.

… The Alexander Gitlin Lab studies how inflammatory cell signaling controls the nature and magnitude of inflammation under physiological and disease conditions. Innate immune cells are tasked with integrating diverse molecular signals from both host and pathogen to produce appropriately commensurate inflammatory

Physician-scientist Adam Schmitt studies how long noncoding RNAs regulate cellular stress responses and tumor development.

… Until recently, the vast majority of the noncoding genome was thought be nonfunctional. Thanks to the rapid development of functional genomics, we now know that the noncoding genome is packed with a diverse array of noncoding RNAs and gene regulatory elements. Indeed, it is estimated that more than 80

Dr. Yueming Li studies disease mechanism of Cancer and Alzheimer’s, with the goal of developing novel therapeutics for clinical use.

… Research Interests Basic & Translational research in Cancer and Alzheimer’s disease: From disease mechanism to therapeutic development. Research Areas Target Identification & Drug Discovery Chemical Biology & Medicinal Chemistry Biochemistry & Enzymology Biophysics & Structural Biology Animal models

Cell biologist Meng-Fu Bryan Tsou studies cell cycle control of centrosome duplication and degeneration, as well as cilia assembly and disassembly.

… The goal of my research is to understand the biogenesis of centrioles/centrosomes and primary cilia, and how defects in these processes affect mammalian cell physiology and evoke stress responses. Using quantitative proteomics, super-resolution microscopy, comparative genomics, proximity labeling, and

Craig Thompson studies molecular signaling pathways that regulate nutrient uptake and the role these pathways play in the regulation of cell growth and survival.

… The Thompson laboratory has proposed that the basis of metazoan cell survival is determined by the inability of cells to take up nutrients in a cell-autonomous fashion. This hypothesis was formulated to explain how multicellularity might have arisen during evolution. We believe the lack of a cell-intrinsic

Kenneth Marians focuses on mechanisms of replication restart and chromosome segregation.

… Research in my laboratory centers on: (i) the events that occur when the replisome (the multi-component enzyme machine that replicates chromosomal DNA) encounters blockages to replication fork progression, and (ii) the mechanisms by which chromosomes are condensed and separated during cell division.

The Jasin laboratory focuses on double-strand break repair and genomic integrity in mammalian cells and the relationship to tumor suppression.

… Human chromosomes are constantly assaulted by challenges to their integrity as a result of either environmental agents that damage DNA or from normal DNA metabolism. The failure to repair damaged DNA faithfully is ultimately responsible for many human diseases, especially cancer. This laboratory focuses