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Physician-scientist Karuna Ganesh studies stem cell plasticity in metastasis, therapy resistance and tissue regeneration.

… Metastasis causes >90% of cancer death.  The emergence, persistence, therapy resistance and lethality of metastatic cancer is driven by dynamic and tenacious metastasis stem cells (MetScs). The Ganesh lab focuses on understanding the molecular mechanisms that underlie the emergence of regenerative plasticity

Physician-scientist Adrienne Boire studies metastasis to the central nervous system.

… The Boire lab studies leptomeningeal metastasis as a means to understand the principles of metastasis as well as the nervous system’s relationship to the larger organism. Adrienne A. Boire, MD, PhD Scientific Director, Alan and Sandra Gerry Metastasis and Tumor Ecosystems Center Associate Professor PhD

The Sheu-Gruttadauria Lab investigates how biomolecular condensates and biological phase transitions shape gene expression in physiology and disease.

… The Sheu-Gruttadauria Lab asks fundamental questions about how the cell organizes gene expression. We are particularly interested in biomolecular condensates, a class of membraneless cellular compartments that concentrate factors involved in nearly every step of RNA metabolism from transcription to decay

Dr. Yueming Li studies disease mechanism of Cancer and Alzheimer’s, with the goal of developing novel therapeutics for clinical use.

… Research Interests Basic & Translational research in Cancer and Alzheimer’s disease: From disease mechanism to therapeutic development. Research Areas Target Identification & Drug Discovery Chemical Biology & Medicinal Chemistry Biochemistry & Enzymology Biophysics & Structural Biology Animal models

Physician-scientist Adam Schmitt studies how long noncoding RNAs regulate cellular stress responses and tumor development.

… Until recently, the vast majority of the noncoding genome was thought be nonfunctional. Thanks to the rapid development of functional genomics, we now know that the noncoding genome is packed with a diverse array of noncoding RNAs and gene regulatory elements. Indeed, it is estimated that more than 80

Physician-scientist Richard Kolesnick studies the role of ceramide signaling in radiation-induced vascular dysfunction and tumor regression.

… Our laboratory focuses on the role of sphingolipid signaling as a stress response. In this pathway, generation of the second messenger ceramide in response to diverse environmental and pharmacologic stresses (heat, ionizing radiation, ultraviolet light, chemotherapeutic agents, oxidative challenges,

Cell biologist Michael Overholtzer studies the mechanisms of tumor initiation and progression, cell adhesion, and cell death.

… The Overholtzer lab studies mechanisms of nutrient sensing and cellular responses to nutrient starvation, including the nutrient recycling pathway autophagy, scavenging pathways such as macropinocytosis, and mechanisms of cell death. We investigate cell death mechanisms that have unique effects on cell

We develop and clinically deploy novel computational algorithms for analyzing multiscale, multimodal biomedical imaging data.

… The Nadeem Lab analyzes, interprets, and infers novel insights from biomedical data at multiple scales (macro: radiology/ surgery, meso: pathology, micro: genomics/ transcriptomics/ proteomics/ metabolomics) for improving patient outcomes. We use advanced mathematical and machine learning techniques

The Mara Sherman lab aims to understand the heterocellular interactions among pancreatic cancer cells and their surrounding microenvironment, and to target these networks for therapeutic benefit.

… The Mara Sherman lab aims to understand the heterocellular interactions among pancreatic cancer cells and their surrounding microenvironment, and to target these networks for therapeutic benefit. Our research focuses on the tumor-permissive molecular mechanisms underlying cancer-associated fibroblast

Physician-scientist Omar Abdel-Wahab studies the functional genomics of hematopoietic malignancies.

… Omar Abdel-Wahab is the Chair of SKI Molecular Pharmacology Program and an Attending Physician on the Leukemia Service in the Department of Medicine at Memorial Sloan Kettering Cancer Center. Omar Abdel-Wahab, MD Chair, Molecular Pharmacology Program, SKI; Evnin Family Chair in Molecular Pharmacology