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The Gitlin Lab studies the molecular and cellular mechanisms underlying inflammatory cell signaling in health and disease.

… The Alexander Gitlin Lab studies how inflammatory cell signaling controls the nature and magnitude of inflammation under physiological and disease conditions. Innate immune cells are tasked with integrating diverse molecular signals from both host and pathogen to produce appropriately commensurate inflammatory

My laboratory and clinical research focus on understanding genomics and signaling in colorectal cancer to develop new treatments for patients.

… My laboratory and clinical research focus on understanding genomics and signaling in colorectal cancer to develop new treatments for patients. Colorectal tumors are characterized by a high level of baseline receptor tyrosine kinase (RTK) signaling. Oncogenic inhibition of these tumors, for example with

Kenneth Marians focuses on mechanisms of replication restart and chromosome segregation.

… Research in my laboratory centers on: (i) the events that occur when the replisome (the multi-component enzyme machine that replicates chromosomal DNA) encounters blockages to replication fork progression, and (ii) the mechanisms by which chromosomes are condensed and separated during cell division.

Computational chemist John Chodera uses statistical mechanics, molecular modeling, and automated biophysical experiments to help identify new potential therapeutics and investigate mechanisms of drug resistance in cancer.

… The Chodera lab uses computation and experiments to develop quantitative, multiscale models of the effects of small molecules on biomolecular macromolecules and cellular pathways. To do this, the group utilizes physical models and rigorous statistical mechanics, with the overall goals of engineering

Physician-scientist Katharine Hsu studies the biology of human natural killer cells and how they contribute to disease processes.

… My laboratory studies the natural killer (NK) cell and the molecules that control its ability to recognize and kill cancer and virally infected cells. Improved understanding of how NK cells behave is critical to advancing our ability to harness their innate capacity for tumor recognition and eradication

Radiologist and Nuclear Medicine physician Jan Grimm develops novel approaches for improved diagnosis, monitoring and therapy of prostate and other cancers.

… The Grimm lab in the Molecular Pharmacology Program focuses on the development of novel and innovative approaches for cancer diagnostics and therapy. These approaches evaluate underlying biology and utilize nanotechnology, chemistry and physics interrogated with modern imaging methods. The lab focuses

Interventional radiologist Constantinos Sofocleous leads research in the optimization of image-guided therapies for colorectal cancer metastases.

… The Constantinos Sofocleous Lab focuses in the exploration, assessment, and validation of tissue and image biomarkers after local and locoregional therapies for metastatic colorectal cancer. The research staff includes experts in radiation physics, 3D software applications in medicine, histopathology

The Zallen laboratory focuses on the generation of tissue structure through the collective action of cell populations.

… Our lab focuses on the generation of tissue structure through the collective action of cell populations. Jennifer A. Zallen, PhD Member, Developmental Biology Program, SKI; Investigator, Howard Hughes Medical Institute Professor PhD, University of California, San Francisco Email [email protected] Laboratory

Surgeon scientist Vinod Balachandran develops novel immunotherapies for pancreatic cancer.

… Our goal is to discover new ways to stimulate the immune system to treat cancer. We study pancreatic cancer, a model deadly cancer that is refractory to all immunotherapies, as well as nearly all other treatments. We use reverse translation to uncover the biological basis of exceptional response in rare

Physician-scientist Ping Chi studies genetic and epigenetic mechanisms of transcriptional regulation by oncogenic factors in GIST, MPNST, melanoma and other solid tumors.

… It is well recognized that the cellular context contributes to susceptibility to oncogenic transformation mediated by different “driver” oncogenes. The focus of our laboratory is to discover and understand the critical genetic and epigenetic factors that determine the cellular-context-dependent oncogenesis