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My research has focused on the development of novel statistical and bioinformatic methodologies that facilitate the study of translational research questions in cancer genomics and immuno-oncology.

… My research has focused on the development of novel statistical and bioinformatic methodologies that facilitate the study of translational research questions in cancer genomics and immuno-oncology. I developed several algorithms including iCluster and FACETS that are widely used in research community

The Zallen laboratory focuses on the generation of tissue structure through the collective action of cell populations.

… Our lab focuses on the generation of tissue structure through the collective action of cell populations. Jennifer A. Zallen, PhD Member, Developmental Biology Program, SKI; Investigator, Howard Hughes Medical Institute Professor PhD, University of California, San Francisco Email [email protected] Laboratory

Interventional radiologist Constantinos Sofocleous leads research in the optimization of image-guided therapies for colorectal cancer metastases.

… The Constantinos Sofocleous Lab focuses in the exploration, assessment, and validation of tissue and image biomarkers after local and locoregional therapies for metastatic colorectal cancer. The research staff includes experts in radiation physics, 3D software applications in medicine, histopathology

Physician-scientist Richard Wong studies the mechanisms of cancer cell chemotaxis in perineural invasion.

… Perineural invasion (PNI) is an ominous form of cancer progression in which cancer cells invade and track along nerves. PNI occurs most frequently in cancers that affect highly innervated organs, including pancreatic, head and neck, and prostate cancers. It is associated with increased recurrence and

Immunologist Ming Li studies mechanisms of immune regulation, and their relevance to diseases including cancer.

… The pervasive influence of the immune system on human health and disease underscores the importance of a mechanistic understanding of immune regulation under pathophysiological conditions such as cancer. Cancer immunology research in my laboratory aims to decipher the cellular and molecular basis of

Biostatistician Colin Begg has research interests spanning cancer epidemiology and statistical methods that are applicable to clinical research more broadly.

… Dr. Begg has research interests spanning cancer epidemiology and statistical methods that are applicable to clinical research more broadly. In recent years Dr. Begg has been developing methods to identify etiologically distinct cancer sub-types, statistical tests of clonal relatedness of pairs of tumors

Biomedical engineer Daniel Heller is Head of the Cancer Nanotechnology Laboratory, which invents disruptive technologies to revolutionize the diagnosis and treatment of cancer and allied diseases.

… Cancer Nanomedicine Laboratory We are a biomedical engineering laboratory that develops nanotechnologies to advance breakthroughs in the research, diagnosis, and treatment of cancer and allied diseases. We develop drug delivery technologies to target therapies to disease sites, advanced diagnostics to

The Vierbuchen laboratory directs the differentiation of mouse and human pluripotent stem cells to characterize fundamental mechanisms of neuronal cell fate specification and function.

… The Vierbuchen laboratory seeks to elucidate fundamental mechanisms governing the production of the myriad neuronal cell types required to build functioning neural circuits. To model these dynamic developmental processes, we direct the differentiation of mouse and human pluripotent stem cells into specific

Molecular Pharmacology Program Member David Scheinberg focuses on the discovery and development of novel, specific immunotherapeutic agents and targeted nanodevices for cancer therapy.

… The overall goals of this laboratory are to develop novel targeted immunotherapies based on effectors of the immune system and to understand their mechanisms of action as well as the mechanisms of resistance to them. This includes antibodies, targeted nano-devices, engineered cells, and active specific

Physician-scientist Ingo Mellinghoff studies signal transduction alterations in primary brain tumors.

… Our laboratory focuses on the study of molecular pathways that regulate brain tumor growth. Our long-term goal is to develop therapeutic paradigms that target specific properties of primary brain tumors, including genetic alterations in cancer signaling pathways, unique aspects of brain tumor metabolism